Results 91 to 100 of about 467,300 (362)
Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]
, 2018 Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty +6 more
core +2 more sources
Advanced Science, EarlyView.This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen +7 more
wiley +1 more source
Journal of Lipid Research, 1997 Apolipoprotein-B-48 is a structural protein exclusively associated with post-prandial lipoproteins (chylomicrons). Apolipoprotein B-48 would be a useful marker to monitor the kinetics of chylomicrons in vivo, however, its quantitation is limited because ...
S D Proctor, J C Mamo
doaj
Folding of the apolipoprotein A1 driven by the salt concentration as a possible mechanism to improve cholesterol trapping [PDF]
arXiv, 2014 The folding of the cholesterol trapping apolipoprotein A1 in aqueous solution at increasing ionic strength is studied using atomically detailed molecular dynamics simulations. We calculate various structural properties to characterize the conformation of the protein, such as the radius of gyration, the radial distribution function and the end to end ...
arxiv
The Carboxyl-Terminal Segment of Apolipoprotein A-V Undergoes a Lipid-Induced Conformational Change [PDF]
, 2010 Apolipoprotein (apo) A-V is a 343-residue, multidomain protein that plays an important role in regulation of plasma triglyceride homeostasis. Primary sequence analysis revealed a unique tetraproline sequence (Pro293-Pro296) near the carboxyl terminus of ...
Lee, B. L. +4 more
core +2 more sources
Advanced Science, EarlyView.Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge +10 more
wiley +1 more source
Identification of disulfide-linked apolipoprotein species in human lipoproteins
Journal of Lipid Research, 1993 We wished to determine whether apolipoprotein C-IIToronto, a mutant form of apolipoprotein C-II that contains a C-terminal cysteine residue, exists as a monomeric species or as multiple disulfide-linked species in plasma lipoproteins.
PW Connelly +4 more
doaj
Lipoprotein particles in patients with pediatric Cushing disease and possible cardiovascular risks. [PDF]
, 2019 BackgroundCardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk factors in children with CD.
Belyavskaya, Elena +10 more
core
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Observation of Cholesterol Dissolved in Microscopic Deposits of Free Fatty Acids in the Lumen of an Aorta of a Mouse Model for Human Atherosclerosis [PDF]
SPIE 7 5321A-11 (2004), 2008 The Raman spectrum of microscopic droplets of lipid material on the lumen of the aorta of an apolipoprotein E knock-out mouse were reported in the proceedings of an SPIE conference. Based on the absence of the carbonyl band in the spectrum, at that time it was determined that the spectrum represents free fatty acids rather than triglycerides.
arxiv