Results 281 to 290 of about 13,195,946 (379)

Comparison of Model‐Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue‐Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. McCrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +18 more
wiley   +1 more source

Development and Clinical Application of the Method to Quantitative Concentration of Serum Apolipoprotein B (Second report)

, 1984
Takamitsu Nakano, Yutaka Harano, Hideto Kojima, Yukio Hatanaka, Hideki Hidaka, Atsunori Kashiwagi, Yukio Shigeta, Takaaki Otsuki, Tetsuo Okanishi, Yukio Ochi   +9 more
openalex   +2 more sources

Use of Model‐Based Meta‐Analysis to Inform the Design of Early Clinical Trials of Anti‐Amyloid Beta Therapies in Alzheimer's Disease

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT To inform an efficient development of new investigational anti‐amyloid beta (anti‐Aβ) monoclonal antibodies (mAbs), a modeling‐and‐simulation‐based strategy was proposed. A general modeling framework that links drug exposures to the time course of amyloid plaque removal and amyloid‐related imaging abnormalities characterized by edema and ...
Sagar S. Bachhav, Ana Victoria Ponce‐Bobadilla, Diana Clausznitzer, Sven Stodtmann, Hao Xiong   +4 more
wiley   +1 more source

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver. [PDF]

Mol Metab
Wang H, Nikain C, Fortounas KI, Amengual J, Tufanli O, La Forest M, Yu Y, Wang MC, Watts R, Lehner R, Qiu Y, Cai M, Kurland IJ, Goldberg IJ, Rajan S, Hussain MM, Brodsky JL, Fisher EA.   +17 more
europepmc   +1 more source

Apolipoprotein B Accumulation and Atherosclerotic Lesions in Swine Coronary Arteries

, 1985
Yoshio Yamauchi, Henry F. Hoff
openalex   +2 more sources

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

High Apolipoprotein B/Apolipoprotein A1 is Associated with Vitamin D Deficiency Among Type 2 Diabetes Patients. [PDF]

Diabetes Metab Syndr Obes
Wang S, Gao H, Zhang M, Chen S.
europepmc   +1 more source

Relationship between Plasma Lipids and Apolipoproteins (A-I, A-II, B, C-II, C-III and E)

, 1985
Masahiro Tsuji, Takahito Kondo, Yoshikazu Kawakami, Hajime IDE   +3 more
openalex   +2 more sources

Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces Atherosclerosis

Arteriosclerosis, Thrombosis and Vascular Biology, 2010
R. Klingenberg, M. Lebens, A. Hermansson, G. N. Fredrikson, D. Strodthoff, M. Rudling, D. Ketelhuth, N. Gerdes, J. Holmgren, J. Nilsson, G. Hansson   +10 more
semanticscholar   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source