Results 61 to 70 of about 193,917 (194)

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Colquhoun, David, Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Olsson, Anders G., Schwartz, Gregory G., Shah, Prediman K., Tardif, Jean-Claude, The dal-OUTCOMES Investigators, Wright, R. Scott   +18 more
core   +2 more sources

Apolipoprotein E polymorphism alters the association between body fatness and plasma lipoproteins in women.

Journal of Lipid Research, 1990
The aim of the present study was to investigate the associations between total adiposity, body fat distribution, and plasma lipoprotein levels within groups of women defined on the basis of apolipoprotein E phenotypes, in order to verify whether apoE ...
MC Pouliot, JP Després, S Moorjani, PJ Lupien, A Tremblay, C Bouchard   +5 more
doaj   +1 more source

Apolipoprotein B-100 deficiency. Intestinal steatosis despite apolipoprotein B-48 synthesis. [PDF]

Journal of Clinical Investigation, 1985
We describe a child, the issue of phenotypically normal parents, who had fat malabsorption, both intestinal and hepatic steatosis, and serum cholesterol and triglyceride concentrations of 38 and 63 mg/dl, respectively. Lipoprotein electrophoresis, Ouchterlony double diffusion, and electron microscopy demonstrated that normal low density lipoproteins ...
P N, Herbert, J S, Hyams, D N, Bernier, M M, Berman, A L, Saritelli, K M, Lynch, A V, Nichols, T M, Forte   +7 more
openaire   +2 more sources

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]

, 2017
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T., Duffy, Danielle, Dunbar, Richard L., Fogelman, Alan M., Movva, Rajesh, Navab, Mohamad, Norris, Robert B., Rader, Daniel J.   +7 more
core   +2 more sources

The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
Aim of the investigation — to study serum levels of apolipoprotein A1 and B and their ratio in 174 young adults (average age — 22.47 ± 0.30 years) with childhood-onset growth hormone deficiency. Materials and methods. The study involved 174 patients (124
O.V. Bolshova, T.O. Tkachova, O.A. Vyshnevska, T.M. Malynovska   +3 more
doaj   +1 more source

Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]

, 2016
The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T, Bateman, Randall J, Bollinger, James G, Cairns, Nigel J, Franklin, Erin E, Holtzman, David, Jiang, Hong, Kasten, Tom, Liao, Fan, Mawuenyega, Kwasi G, Morris, John C, Ovod, Vitaliy   +11 more
core   +3 more sources

Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production

Journal of Lipid Research, 2000
In vitro studies have shown that the binding site for microsomal triglyceride transfer protein (MTP) is within the first 17% of apoB (apoB-17). Expression of apoB-48 in McArdle cells decreases endogenous lipoprotein production; however, overexpression of
Zhaohui Li, Yuko Kako, Ling Pang, Mason W. Freeman, Jane M. Glick, Xinzhong Wang, Ira J. Goldberg   +6 more
doaj   +1 more source

Generation of Intracellular Signals by Low Density Lipoprotein Is Independent of the Classical LDL Receptor [PDF]

, 2017
Low density lipoprotein cholesterol (LDL) and apolipoprotein B-100 (1 to 15 μg/mL) had no significant influence on the inositol-1,4,5-trisphosphate (InsPa) formation in vascular smooth muscle cells and fibroblasts. Low density lipoprotein cholesterol (15
Locher, Rudolf, Sachinidis, Agapios, Vetter, Wilhelm   +2 more
core  

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]

, 2017
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core   +1 more source

Efficacy of targeted screening for familial hypercholesterolemia in children and adults aged <44 years: retrospective, prospective observational study [PDF]

КардиоСоматика
BACKGROUND: Considering the high cardiovascular risk in patients with familial hypercholesterolemia (FH), early diagnosis and treatment are the basis for the prevention of vascular accidents.
Elena Yu. Emelyanchik, Anastasia M. Moiseeva, Vasilii S. Emelyanchik, Olga V. Marilovtseva, Roman V. Khomchenkov, Valentina A. Mosina, Irina I. Cherkashina, Sergey A. Ustyugov, Svetlana Yu. Nikulina, Alexey V. Protopopov   +9 more
doaj   +1 more source