Results 161 to 170 of about 55,323 (311)

A robust all-atom model for LCAT generated by homology modeling[S]

Journal of Lipid Research, 2015
LCAT is activated by apoA-I to form cholesteryl ester. We combined two structures, phospholipase A2 (PLA2) that hydrolyzes the ester bond at the sn-2 position of oxidized (short) acyl chains of phospholipid, and bacteriophage tubulin PhuZ, as C- and N ...
Jere P. Segrest, Martin K. Jones, Andrea Catte, Saravana P. Thirumuruganandham   +3 more
doaj  

New genetic variants in the apoA-I and apoC-III genes and familial combined hyperlipidemia

Journal of Lipid Research, 2001
Linkage and association between the apolipoprotein (apo) A-I/C-III/A-IV gene region on chromosome 11 and familial combined hyperlipidemia (FCHL) has been observed previously.
Martine Groenendijk, Rita M. Cantor, Tjerk W.A. De Bruin, Geesje M. Dallinga-Thie   +3 more
doaj  

Immunohistochemical localization of apolipoprotein E in human glial neoplasms [PDF]

, 1989

openalex   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Preparative free-solution isotachophoresis for separation of human plasma lipoproteins: apolipoprotein and lipid composition of HDL subfractions

Journal of Lipid Research, 2000
We have previously shown that plasma lipoproteins can be separated by analytical capillary isotachophoresis (ITP) according to their electrophoretic mobility in a defined buffer system.
Alfred Böttcher, Judith Schlosser, Florian Kronenberg, Hans Dieplinger, Gabriele Knipping, Karl J. Lackner, Gerd Schmitz   +6 more
doaj  

Apolipoprotein C-III [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +7 more sources

Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies.

, 1977
Mary C. Ritter, A M Scanus
openalex   +1 more source

Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia. [PDF]

, 1986
Karl J. Lackner, J C Monge, Richard E. Gregg, J M Hoeg, Timothy J. Triche, S W Law, H. Bryan Brewer   +6 more
openalex   +1 more source

Population pharmacokinetic‐pharmacodynamic analyses of amyloid positron emission tomography and plasma biomarkers for lecanemab in subjects with early Alzheimer's disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1578-1591, December 2022., 2022
Abstract Lecanemab is a humanized immunoglobulin G1 monoclonal antibody that selectively binds to soluble Aβ aggregate species, while demonstrating low affinity for Aβ monomer. This article describes the population pharmacokinetic (PK) and PK/pharmacodynamic (PD) analyses for amyloid plaques, as measured using positron emission tomography (PET), and ...
Seiichi Hayato, Osamu Takenaka, Sree Harsha Sreerama Reddy, Ishani Landry, Larisa Reyderman, Akihiko Koyama, Chad Swanson, Sanae Yasuda, Ziad Hussein   +8 more
wiley   +1 more source

Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention

Journal of Lipid Research, 2017
In the last decade, it has become obvious that Alzheimer's disease (AD) is closely linked to changes in lipids or lipid metabolism. One of the main pathological hallmarks of AD is amyloid-β (Aβ) deposition.
Marcus O.W. Grimm, Daniel M. Michaelson, Tobias Hartmann   +2 more
doaj