Single‐Cell Nanodroplet Processing Proteomics Pipeline for Analysis of Human‐Derived Microglia
ABSTRACT Single‐cell omics tools provide unique insights into heterogeneous cell populations and their responses to stimuli. For example, single‐cell RNA sequencing has identified several transcriptionally distinct populations of microglia, which are resident immune cells of the central nervous system (CNS) that are responsive to CNS injury, infection,
Ashley N. Ives +7 more
wiley +1 more source
The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis. [PDF]
Murad M +10 more
europepmc +1 more source
Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang +5 more
wiley +1 more source
ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease. [PDF]
Santinelli-Pestana DV +15 more
europepmc +1 more source
ABSTRACT To explore associations of vestibular disorders with all‐cause and cause‐specific dementia and underlying biological mechanisms/neuroimaging changes. A population‐based cohort study of 406,348 UK Biobank participants was conducted. Inverse probability of treatment weighting (IPTW) balanced baseline covariates, and Cox proportional hazards ...
Xiaofei Li +15 more
wiley +1 more source
Evidence from Mendelian randomization analysis combined with meta-analysis for the causal validation of the relationship between 35 blood and urine metabolites and lumbar disc herniation. [PDF]
Yang J, Xu W, Chen D, Yang H, Zhou Z.
europepmc +1 more source
The Next Frontier: Micro/Nanorobots Operating Inside the Living Body
Micro/nanorobots, with their tiny size and controllable motion capabilities, can perform complex and precise tasks in micro‐spaces, thus showing broad application prospects in the biomedical field. This review systematically summarizes the core advantages of micro/nanorobots in real‐time in vivo imaging, targeted drug delivery, and active barrier ...
Ningbo Yu +5 more
wiley +1 more source
Vitamin D immune modulation of the anti-inflammatory effects of HDL-associated proteins. [PDF]
Mousa H, Zughaier SM.
europepmc +1 more source

