Results 251 to 260 of about 55,604 (311)

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source

Lipids, apolipoproteins, carbohydrates, and risk of hematological malignancies. [PDF]

Eur J Epidemiol
Liu Q, Wei D, Hammar N, Yang Y, Feychting M, Zhang Z, Walldius G, Smedby KE, Fang F.   +8 more
europepmc   +1 more source

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.

, 1989
Clive R. Pullinger, Julia D. North, Ba‐Bie Teng, Vincent A. Rifici, A E Ronhild de Brito, Jenny Scott   +5 more
openalex   +1 more source

Microglia Single‐Cell RNA‐Seq Enables Robust and Applicable Markers of Biological Aging

Aging Cell, EarlyView.
This study develops computational approaches to translate single‐cell based transcriptomic signatures of microglia into aging clocks, or machine learning models of age. These models can be broadly applied to new single‐cell or bulk RNA‐sequencing datasets to gain novel biological insights and evaluate how environmental inputs (such as stress) affect ...
Natalie Stanley, Luvna Dhawka, Sneha Jaikumar, Yu‐Chen Huang, Anthony S. Zannas   +4 more
wiley   +1 more source

Proteomic and Lipidomic Plasma Evaluations Reveal Biomarkers for Domoic Acid Toxicosis in California Sea Lions. [PDF]

J Proteome Res
Solosky AM, Claudio IM, Chappel JR, Kirkwood-Donelson KI, Janech MG, Bland AM, Gulland FMD, Neely BA, Baker ES.   +8 more
europepmc   +1 more source

Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.

, 1985
S K Karathanasis
openalex   +1 more source

Long‐term alcohol consumption and incident health risk conditions related to cardiometabolic risk markers: A 20‐year prospective cohort study

Addiction, EarlyView.
Abstract Background and aims Amid questions about a perceived association between low‐to‐moderate alcohol consumption and reduced cardiovascular risk from recent studies, research examining the impact of alcohol consumption on cardiometabolic risk markers has reported inconsistent results.
Sooyeun Choi, Taeyoung Park, Youjin Je
wiley   +1 more source

Divergent Roles of APOAI and APOM in the Identification of Alcohol Use Disorder and Their Association With Inflammation and Cognitive Decline: A Pilot Study. [PDF]

Int J Neuropsychopharmacol
Escudero B, López-Valencia L, Arias Horcajadas F, Orio L.   +3 more
europepmc   +1 more source

The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.

, 1983
Karl H. Weisgraber, T L Innerarity, K J Harder, Robert W. Mahley, R W Milne, Yves L. Marcel, James T. Sparrow   +6 more
openalex   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source