Results 261 to 270 of about 55,604 (311)

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

open access: yesAnnals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

Systematic Review of Rare Major Adverse Cardiovascular Events Associated With the Treatment of Acne With Isotretinoin

open access: yesAustralasian Journal of Dermatology, Volume 66, Issue 3, Page e97-e108, May 2025.
ABSTRACT Acne vulgaris is a common inflammatory condition that is often treated by dermatologists with isotretinoin. Isotretinoin has a number of effects on inflammatory pathways, with clear efficacy in managing acne vulgaris. There are also well‐documented side effects of isotretinoin, including hyperlipidemia; however, the overall cardiovascular risk
Timothy L. Cowan   +3 more
wiley   +1 more source

Engineered nanoparticles potentials in male reproduction

open access: yesAndrology, Volume 13, Issue 4, Page 694-705, May 2025.
Abstract Background The escalating prevalence of fertility problems in the aging population necessitates a comprehensive exploration of contributing factors, extending beyond environmental concerns, work‐related stress, and unhealthy lifestyles. Among these, the rising incidence of testicular disorders emerges as a pivotal determinant of fertility ...
Feifei Zhao   +8 more
wiley   +1 more source

Challenges and opportunities for statistical power and biomarker identification arising from rhythmic variation in proteomics. [PDF]

open access: yesNPJ Biol Timing Sleep
Spick M   +8 more
europepmc   +1 more source

The Lipidomic Profile Discriminates Between MASLD and MetALD

open access: yesAlimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1357-1371, April 2025.
HDL‐centric lipidomic biomarkers, particularly within large and medium HDL subfractions, distinguish metabolic dysfunction and alcohol‐related liver disease from metabolic dysfunction‐associated steatotic liver disease, suggesting potential biomarkers for clinical differentiation.
Kai Markus Schneider   +15 more
wiley   +1 more source

Clearance of Hepatitis C Viremia During Direct‐Acting Antiviral Therapy Leads to Rapid Changes in Lipid and Lipoprotein Metabolism

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
HCV clearance during direct‐acting antiviral therapy rapidly increases serum lipids and lipoproteins, potentially elevating cardiovascular risk. These metabolic changes, mediated by genes regulating hepatic lipogenesis, suggest that lipid levels should be closely monitored post‐SVR to assess long‐term cardiovascular implications.
Zahra Sarrafan‐Chaharsoughi   +12 more
wiley   +1 more source

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