Results 271 to 280 of about 55,604 (311)

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Activating transcription factor 3 regulates hepatic apolipoprotein A4 upon metabolic stress. [PDF]

J Biol Chem
Encarnacion J, Smith DM, Choi J, Scafidi J, Wolfgang MJ.   +4 more
europepmc   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Apolipoproteins, lipids, lipid-lowering drugs and risk of amyotrophic lateral sclerosis and frontotemporal dementia: a meta-analysis and Mendelian randomisation study. [PDF]

J Neurol
Chalitsios CV, Ley H, Gao J, Turner MR, Thompson AG.   +4 more
europepmc   +1 more source

Truncated variant rs373056577 confers increased risk of type 2 diabetes and missense variant rs121912717 is associated with hypertriglyceridemia in Bangladeshi population. [PDF]

Metabol Open
Sayed S, Saba AA, Hasan I, Rahat R, Sayem M, Ebihara A, Nabi AHMN.   +6 more
europepmc   +1 more source

Elevated Triglyceride‐Glucose Index Is Associated With Insulin Resistance, Metabolic Syndrome Components, Nonalcoholic Fatty Liver Disease, and Adverse Pregnancy Outcomes in Chinese Women With Polycystic Ovary Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Aim To investigate the associations of triglyceride‐glucose index (TyG) with anthropometric characteristics, metabolic/endocrine profiles, and pregnancy outcomes in Chinese women with polycystic ovary syndrome (PCOS). Methods This secondary analysis of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome trial ...
Jiaxing Feng, Rong Luo, Jingshu Gao, Yu Wang, Jing Cong, Hongli Ma, Xiaoke Wu   +6 more
wiley   +1 more source

Uncovering host response in adults with severe community-acquired pneumonia: a proteomics and metabolomics perspective study. [PDF]

World J Emerg Med
Kuang Z, Li R, Lu S, Wang Y, Luo Y, Shen Y, Yuan L, Yang Y, Song Z, Jiang N, Tong C.   +10 more
europepmc   +1 more source

A Genetic and Environmental Analysis of Inflammatory Factors in Chronic Widespread Pain Using the TwinsUK Cohort. [PDF]

Biomolecules
Cherny SS, Livshits G, Williams FMK.
europepmc   +1 more source