Cyclodextrin‐Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery
Small, EarlyView.Host–guest interactions between cyclodextrin (CD) and compatible guest molecules enable the formation of diverse architectures, such as multiblock and linear–star copolymers as well as advanced systems like redox‐responsive nanoparticles. This structural versatility facilitates precise system design, conferring multifunctionality for controlled drug ...
Wilson Wee Mia Soh, Jun Li
wiley +1 more source
Label-Free Proteomics of Severe Acute Hepatitis of Unknown Origin in Children by High-Resolution Mass Spectrometry. [PDF]
ACS Omegade Farias JB +5 more
europepmc +1 more source
Small, EarlyView.This work presents a proof‐of‐concept digital microfluidic device that can automatedly extract EVs from microliters of biological and physiological fluids within 25 min and detect EV‐bound protein markers on‐chip using electrochemical sensor. This work serves as a framework for the development of streamlined EV analysis in both medicine research and ...
Ting‐Wen Lo +7 more
wiley +1 more source
Assessing the causal relationships between circulating metabolic biomarkers and breast cancer by using mendelian randomization. [PDF]
Front GenetWang B, Ling Y, Zhang H, Yang M.
europepmc +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women. [PDF]
Environ HealthZhu L +7 more
europepmc +1 more source
Therapeutic Implications of Biomolecular Corona on Lipid Nanoparticle‐Based Gene Delivery Systems
Small Science, EarlyView.This image illustrates the role of the biomolecular corona in lipid nanoparticles (LNPs), highlighting its impact on the stability, immune response, biodistribution, and targeted delivery. Formed after injection, the corona influences how LNPs circulate, interact with the cells, and modulate the immune response.
Antonietta Greco, Claudia Corbo
wiley +1 more source
Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention. [PDF]
Arch Endocrinol MetabMarcadenti A +8 more
europepmc +1 more source
Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
Small Methods, EarlyView.The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu +6 more
wiley +1 more source
Protein Adsorption on Nano- and Microparticles: Dependence on Morphological and Physicochemical Properties of Particles and Effect on Particle-Cell Interactions. [PDF]
Nanomaterials (Basel)Gerasimovich E +3 more
europepmc +1 more source