Results 61 to 70 of about 55,323 (311)

Non‐Enzymatic Destruction of the Extracellular Matrix for Activatable Orthotopic Tumor Treatment and Enhanced Drug Penetration

Advanced Functional Materials, EarlyView.
Supramolecular biomimetic nanoaggregates (HFCu NAs), constructed with fluorinated histidine and copper ions via metal coordination and aromatic packing, exhibit enhanced reactive oxygen species （ROS）generation at tumor sites, which results in stepwise collapse of the extracellular matrix (ECM), affording tumor microenvironment responsive “turn‐on” 19F ...
Hui Wang, Ruxin Feng, Yan Wang, Qian Ma, Di Yuan, Xi Yang, Suying Xu, Tony D. James, Leyu Wang   +8 more
wiley   +1 more source

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022
Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner, Nikolaus Romani, Christoph Rademacher, Hans Christian Probst, Karsten Mahnke   +4 more
wiley   +1 more source

Simultaneous LC/MS/MS quantification of eight apolipoproteins in normal and hypercholesterolemic mouse plasma[S]

Journal of Lipid Research, 2019
Apolipoproteins are major structural and functional constituents of lipoprotein particles. As modulators of lipid metabolism, adipose tissue biology, and energy homeostasis, apolipoproteins may serve as biomarkers or potential therapeutic targets for ...
Richard Wagner, Julia Dittrich, Joachim Thiery, Uta Ceglarek, Ralph Burkhardt   +4 more
doaj  

Interaction of apolipoprotein(a) with apolipoprotein B-containing lipoproteins.

Journal of Biological Chemistry, 1991
Recombinant DNA-derived apolipoprotein(a) was used to demonstrate that the apo(a) moiety of lipoprotein(a) (Lp(a)) is responsible for the binding of Lp(a) to other apolipoprotein B-containing lipoproteins (apoB-Lp) including LDL2, a subclass of low density lipoproteins (d = 1.030-1.063 g/ml).
Walter J. McConathy, T F Zioncheck, V N Trieu, R M Lawn   +3 more
openaire   +3 more sources

Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone

Advanced Therapeutics, EarlyView.
Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe, Jena E. Moseman, Jamie M. Jones, Jacobus C. Burger, Ashley M. Weichmann, Douglas G. McNeel, William L. Murphy   +6 more
wiley   +1 more source

Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022
Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen, Isaac Kyei, Arden Hatch, David S. Hage   +3 more
wiley   +1 more source

Observation of Cholesterol Dissolved in Microscopic Deposits of Free Fatty Acids in the Lumen of an Aorta of a Mouse Model for Human Atherosclerosis [PDF]

SPIE 7 5321A-11 (2004), 2008
The Raman spectrum of microscopic droplets of lipid material on the lumen of the aorta of an apolipoprotein E knock-out mouse were reported in the proceedings of an SPIE conference. Based on the absence of the carbonyl band in the spectrum, at that time it was determined that the spectrum represents free fatty acids rather than triglycerides.
arxiv  

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Advanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini, Roberto Frigerio, Jonathan Garlipp, Philippe Lenzen, Karl Normak, Carolina Paganini, Marina Cretich, Alessandro Gori, Paolo Arosio   +8 more
wiley   +1 more source

Plasma lipoproteins: apolipoprotein structure and function.

Journal of Lipid Research, 1984
Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III ...
R W Mahley, T L Innerarity, S C Rall, Jr, K H Weisgraber   +3 more
doaj  

Nanoparticle charge-transfer interactions induce surface dependent conformational changes in apolipoprotein biocorona [PDF]

arXiv, 2016
Upon introduction into a biological system, engineered nanomaterials (ENMs) rapidly associate with a variety of biomolecules such as proteins and lipids to form a biocorona. The presence of biocorona influences nano-bio interactions considerably, and could ultimately result in altered biological responses.
arxiv