Results 81 to 90 of about 26,040 (266)

Effects of a dietary intervention with lacto-ovo-vegetarian and Mediterranean diets on apolipoproteins and inflammatory cytokines: results from the CARDIVEG study

Nutrition & Metabolism
Background Apolipoproteins have been recently proposed as novel markers of cardiovascular disease (CVD) risk. However, evidence regarding effects of diet on apolipoproteins is limited.
Giuditta Pagliai, Marta Tristan Asensi, Monica Dinu, Francesca Cesari, Alessia Bertelli, Anna Maria Gori, Betti Giusti, Rossella Marcucci, Francesco Sofi, Barbara Colombini   +9 more
doaj   +1 more source

N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis

Journal of Lipid Research, 2019
ApoA-I and ABCA1 play important roles in nascent HDL (nHDL) biogenesis, the first step in the pathway of reverse cholesterol transport that protects against cardiovascular disease. On the basis of the crystal structure of a C-terminally truncated form of
Minjing Liu, Xiaohu Mei, Haya Herscovitz, David Atkinson   +3 more
doaj   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients

Journal of Lipid Research, 2015
The purpose of this work was to investigate the associations of serum cholesterol and apolipoproteins with measures of blood-brain barrier (BBB) permeability and CNS inflammation following the first clinical demyelinating event.
Kelly Fellows, Tomas Uher, Richard W. Browne, Bianca Weinstock-Guttman, Dana Horakova, Helena Posova, Manuela Vaneckova, Zdenek Seidl, Jan Krasensky, Michaela Tyblova, Eva Havrdova, Robert Zivadinov, Murali Ramanathan   +12 more
doaj   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL[S]

Journal of Lipid Research, 2018
APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL';s cardioprotective functions, in part via its activation of the enzyme, LCAT.
Allison L. Cooke, Jamie Morris, John T. Melchior, Scott E. Street, W.Gray Jerome, Rong Huang, Andrew B. Herr, Loren E. Smith, Jere P. Segrest, Alan T. Remaley, Amy S. Shah, Thomas B. Thompson, W.Sean Davidson   +12 more
doaj   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice[S]

Journal of Lipid Research, 2016
The acute phase (AP) reactant serum amyloid A (SAA), an HDL apolipoprotein, exhibits pro-inflammatory activities, but its physiological function(s) are poorly understood.
Myung-Hee Kim, Maria C. de Beer, Joanne M. Wroblewski, Richard J. Charnigo, Ailing Ji, Nancy R. Webb, Frederick C. de Beer, Deneys R. van der Westhuyzen   +7 more
doaj   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Reduction in apolipoprotein-mediated removal of cellular lipids by immortalization of human fibroblasts and its reversion by cAMP: lack of effect with Tangier disease cells

Journal of Lipid Research, 1999
High density lipoprotein (HDL) phospholipids and apolipoproteins remove cellular lipids by two distinct mechanisms, but their relative contribution to reverse cholesterol transport is unknown.
John F. Oram, Armando J. Mendez, James Lymp, Terrance J. Kavanagh, Christine L. Halbert   +4 more
doaj   +1 more source