Results 1 to 10 of about 50,002 (295)
Determinants of cholesterol efflux capacity in humans
Progress in Lipid Research, 2018 High-density lipoproteins (HDL) play an important role in the reverse cholesterol transport (RCT) pathway, contributing to the efflux of excess cellular cholesterol.
Jogchum Plat +2 more
exaly +4 more sources
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol
Journal of Lipid Research, 2011 Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [3H]cholesterol and measuring release of the labeled ...
Ginny Kellner-Weibel +2 more
exaly +3 more sources
Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess cholesterol.
Alice Dupont Juhl, Daniel Wüstner
doaj +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang +9 more
doaj +2 more sources
Cellular cholesterol efflux to serum is impaired in diabetic nephropathy
Diabetes/Metabolism Research and Reviews, 2008 Background: Cholesterol efflux from cells is an early step of reverse cholesterol transport (RCT) and the capacity of serum to induce cellular cholesterol efflux has recently been shown to be an independent predictor of coronary artery atherosclerosis ...
Huali Zhou, Kathryn C B Tan, Ying Wong
exaly +2 more sources
Journal of Lipid Research, 1997 It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins.
A J Mendez
doaj +2 more sources
Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages
FEBS Open Bio, 2021 Apolipoprotein M (ApoM) exhibits various anti‐atherosclerotic functions as a component of high‐density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR‐BI) is a classic HDL receptor that mediates selective cholesterol uptake and ...
Shuang Yao +6 more
doaj +2 more sources
E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1 [PDF]
The Journal of Clinical InvestigationAtherosclerosis arises from disrupted cholesterol metabolism, notably impaired macrophage cholesterol efflux leading to foam cell formation. Through single-cell and bulk RNA-Seq, we identified Listerin E3 ubiquitin protein ligase 1 (Listerin) as a ...
Lei Cao +17 more
doaj +2 more sources
Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]
PLoS ONE, 2016 Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano +6 more
doaj +1 more source
New Strategies to Promote Macrophage Cholesterol Efflux
Frontiers in Cardiovascular Medicine, 2021 The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi +3 more
doaj +1 more source