Results 1 to 10 of about 378,964 (291)

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol

Journal of Lipid Research, 2011
Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [3H]cholesterol and measuring release of the labeled ...
Michael Phillips, Bela Asztalos, Margarita de la Llera-Moya   +2 more
exaly   +3 more sources

Cholesterol efflux pathways, inflammation, and atherosclerosis [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2021
Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization studies and the majority of clinical trials not showing any benefit of plasma HDL-cholesterol raising ...
Alan Tall, Marit Westerterp, Anouk Groenen   +2 more
exaly   +3 more sources

Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1s⃞ [PDF]

Journal of Lipid Research, 2007
ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver.
Osamu Sano, Aya Kobayashi, Kohjiro Nagao, Keigo Kumagai, Noriyuki Kioka, Kentaro Hanada, Kazumitsu Ueda, Michinori Matsuo   +7 more
doaj   +3 more sources

E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1 [PDF]

The Journal of Clinical Investigation
Atherosclerosis arises from disrupted cholesterol metabolism, notably impaired macrophage cholesterol efflux leading to foam cell formation. Through single-cell and bulk RNA-Seq, we identified Listerin E3 ubiquitin protein ligase 1 (Listerin) as a ...
Lei Cao, Jie Zhang, Liwen Yu, Wei Yang, Wenqian Qi, Ruiqing Ren, Yapeng Liu, Yonghao Hou, Yu Cao, Qian Li, Xiaohong Wang, Zhengguo Zhang, Bo Li, Wenhai Sui, Yun Zhang, Chengjiang Gao, Cheng Zhang, Meng Zhang   +17 more
doaj   +2 more sources

Cholesterol efflux [PDF]

Arteriosclerosis thrombosis and vascular biology, 2012
Monocytosis and neutrophilia are well-established risk factors for atherosclerosis and seem to play a causative role in lesion development. Studies in mice with defects in cholesterol efflux pathways have identified novel roles for the ATP-binding cassette transporter A1, ATP-binding cassette transporter G1, and apolipoprotein E in suppressing ...
Tall, Alan R, Yvan-Charvet, Laurent, Westerterp, Marit, Murphy, Andrew J   +3 more
openaire   +3 more sources

Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]

PLoS ONE, 2016
Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Hiraku Ono, Shigehiro Katayama, Takuya Awata, Takayuki Murakoshi   +6 more
doaj   +1 more source

Targeted cholesterol efflux [PDF]

Cell Cycle, 2013
In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in ...
Fang, Longhou, Miller, Yury I
openaire   +2 more sources

Cholesterol Efflux Assay [PDF]

Journal of Visualized Experiments, 2012
Cholesterol content of cells must be maintained within the very tight limits, too much or too little cholesterol in a cell results in disruption of cellular membranes, apoptosis and necrosis. Cells can source cholesterol from intracellular synthesis and from plasma lipoproteins, both sources are sufficient to fully satisfy cells' requirements for ...
Hann, Low, Anh, Hoang, Dmitri, Sviridov
openaire   +2 more sources

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]

QJM: An International Journal of Medicine, 2005
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
R, Ohashi, H, Mu, X, Wang, Q, Yao, C, Chen   +4 more
openaire   +2 more sources