Results 1 to 10 of about 26,719 (220)

The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64) in BRIN-BD11 insulinoma cells [PDF]

, 2016
No abstract ...
Borges Pinto, Joana, Graham, Annette
core   +4 more sources

Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells

Journal of Lipid Research, 2003
Adipose cells specialized in energy storage, contain large intracellular triglyceride-rich lipid droplets, are enriched with free cholesterol, and express sterol-regulated transcription factors such as liver X receptor (LXR). The recent identification of
Soazig Le Lay, Céline Robichon, Xavier Le Liepvre, Georges Dagher, Pascal Ferre, Isabelle Dugail   +5 more
doaj   +1 more source

Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

Frontiers in Cardiovascular Medicine, 2021
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis.
Yan Liu, Yan Sun, Xuze Lin, Dai Zhang, Chengping Hu, Jinxing Liu, Yong Zhu, Ang Gao, Hongya Han, Meng Chai, Jianwei Zhang, Yujie Zhou, Yingxin Zhao   +12 more
doaj   +1 more source

Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

Journal of Pharmacological Sciences, 2011
.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation.
Takashi Maejima, Tomohiro Sugano, Hiroyuki Yamazaki, Yasunobu Yoshinaka, Takeshi Doi, Sohei Tanabe, Tomoko Nishimaki-Mogami   +6 more
doaj   +1 more source

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]

, 2019
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria, Dolan, Sharron, Graham, Annette, Lightbody, Richard J., Tarlton, Jamie M.R.   +4 more
core   +1 more source

Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis

Journal of Lipid Research, 2007
It is well accepted that both apolipoprotein A-I (apoA-I) and ABCA1 play crucial roles in HDL biogenesis and in the human atheroprotective system. However, the nature and specifics of apoA-I/ABCA1 interactions remain poorly understood.
Houssein Hajj Hassan, Maxime Denis, Dong-Young Donna Lee, Iulia Iatan, Dana Nyholt, Isabelle Ruel, Larbi Krimbou, Jacques Genest   +7 more
doaj   +1 more source

Chlamydial infection from outside to inside [PDF]

, 2019
Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke, Sanders, Niek, Vanrompay, Daisy   +2 more
core   +2 more sources

Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1

Journal of Lipid Research, 2006
ABCA1 mediates the transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Apolipoprotein A-I (apoA-I) interactions with ABCA1-expressing cells elicit several responses, including removing cellular lipids, stabilizing ABCA1 protein ...
Chongren Tang, Ashley M. Vaughan, G.M. Anantharamaiah, John F. Oram   +3 more
doaj   +1 more source

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDLs⃞

Journal of Lipid Research, 2007
HDL promotes cholesterol efflux from peripheral cells via ABCA1 in the first step of reverse cholesterol transport (RCT). We investigated whether the early steps of RCT were disturbed in subjects with familial low HDL and an increased risk for early ...
Aino Soro-Paavonen, Jussi Naukkarinen, Miriam Lee-Rueckert, Hiroshi Watanabe, Elina Rantala, Sanni Soderlund, Anne Hiukka, Petri T. Kovanen, Matti Jauhiainen, Leena Peltonen, Marja-Riitta Taskinen   +10 more
doaj   +1 more source