Results 1 to 10 of about 11,658 (183)

ATP-binding cassette transporter A1: From metabolism to neurodegeneration [PDF]

Neurobiology of Disease, 2014
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport — a role ...
Radosveta Koldamova, Nicholas F. Fitz, Iliya Lefterov   +2 more
doaj   +5 more sources

A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. [PDF]

PLoS ONE, 2011
Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, the effect of ApoE on the expression of ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective of this study was to determine the effect of
Yanfeng Zhao, Xinping Chen, Hong Yang, Lichun Zhou, Emmanuel U Okoro, Zhongmao Guo   +5 more
doaj   +4 more sources

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang, Anela Tosevska, Elke H. Heiß, Angela Ladurner, Christine Mölzer, Marlies Wallner, Andrew Bulmer, Karl‐Heinz Wagner, Verena M. Dirsch, Atanas G. Atanasov   +9 more
doaj   +2 more sources

ATP-binding cassette transporter A1 expression is decreased in preeclamptic placentas. [PDF]

Reprod Sci, 2013
Preeclampsia is a pregnancy-specific multisystem disorder characterized by hypertension and proteinuria. Accentuated maternal hyperlipidemia, especially high serum levels of oxidized low-density lipoprotein (oxLDL), is one of the features of preeclampsia.
Chigusa Y, Kondoh E, Mogami H, Nishimura F, Ujita M, Kawasaki K, Fujita K, Tatsumi K, Konishi I.   +8 more
europepmc   +4 more sources

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function [PDF]

Circulation Research, 2009
ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotein A-I. However, how ABCA1 targeting to these specific membranes is regulated remains unknown.
Michael R Hayden, Roshni Singaraja, Jonathan Coutinho   +2 more
exaly   +3 more sources

ATP-binding cassette transporter A1: A promising therapy target for prostate cancer. [PDF]

Mol Clin Oncol, 2018
ATP-binding cassette transporter A1 (ABCA1) has been found to mediate the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I (apoA-I), and is essential for the synthesis of high-density lipoprotein. Mutations of the ABCA1 gene may induce Tangier disease and familial hypoalphalipoproteinemia; they may also lead to loss of ...
Xiong T, Xu G, Huang XL, Lu KQ, Xie WQ, Yin K, Tu J.   +6 more
europepmc   +4 more sources

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. [PDF]

PLoS ONE, 2014
Hepatitis C virus (HCV) establishes infection using host lipid metabolism pathways that are thus considered potential targets for indirect anti-HCV strategies.
Simone Bocchetta, Patrick Maillard, Mami Yamamoto, Claire Gondeau, Florian Douam, Stéphanie Lebreton, Sylvie Lagaye, Stanislas Pol, François Helle, Wanee Plengpanich, Maryse Guérin, Maryline Bourgine, Marie Louise Michel, Dimitri Lavillette, Philippe Roingeard, Wilfried le Goff, Agata Budkowska   +16 more
doaj   +2 more sources

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration. [PDF]

Biochim Biophys Acta, 2010
ATP-binding cassette transporter A1 - ABCA1, is the most extensively studied transporter in human pathology. ABCA1 became a primary subject of research in many academic and pharmaceutical laboratories immediately after the discovery that mutations at the gene locus cause severe familial High Density Lipoprotein (HDL) deficiency and, in the homozygous ...
Koldamova R, Fitz NF, Lefterov I.
europepmc   +4 more sources

Functional characterization of genetic variants affecting the intracellular domains of ATP-binding cassette transporter A1 (ABCA1) [PDF]

Journal of Lipid Research
The ATP-binding cassette transporter A1 (ABCA1) effluxes cellular cholesterol and phospholipids to extracellular acceptors, mainly apolipoprotein A1, generating high-density lipoprotein (HDL) particles.
Marianne Teigen, Åsa Schawlann Ølnes, Katrine Bjune, Martin Prøven Bogsrud, Thea Bismo Strøm   +4 more
doaj   +2 more sources

ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity [PDF]

Diabetes, Metabolic Syndrome and Obesity, 2019
Vinnyfred Vincent,1 Himani Thakkar,1 Sandeep Aggarwal,2 Asit Ranjan Mridha,3 Lakshmy Ramakrishnan,4 Archna Singh1 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 2Department of Surgical Disciplines, All India ...
Vincent V, Thakkar H, Aggarwal S, Mridha AR, Ramakrishnan L, Singh A   +5 more
doaj   +2 more sources