Results 21 to 30 of about 1,999,074 (184)

ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol [PDF]

Journal of Biological Chemistry, 2001
Alpha-tocopherol (alpha-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting alpha-TOH between tissues. Here we show that secretion of alpha-TOH from cultured cells is mediated in part by ABCA1, an ATP-binding cassette protein that transports cellular
J F, Oram, A M, Vaughan, R, Stocker
openaire   +2 more sources

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. [PDF]

PLoS ONE, 2014
Hepatitis C virus (HCV) establishes infection using host lipid metabolism pathways that are thus considered potential targets for indirect anti-HCV strategies.
Simone Bocchetta, Patrick Maillard, Mami Yamamoto, Claire Gondeau, Florian Douam, Stéphanie Lebreton, Sylvie Lagaye, Stanislas Pol, François Helle, Wanee Plengpanich, Maryse Guérin, Maryline Bourgine, Marie Louise Michel, Dimitri Lavillette, Philippe Roingeard, Wilfried le Goff, Agata Budkowska   +16 more
doaj   +1 more source

Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients

Frontiers in Pharmacology, 2021
Objective: It has been reported that atrial natriuretic peptide (ANP) regulates lipid metabolism by stimulating adipocyte browning, lipolysis, and lipid oxidation, and by impacting the secretion of adipokines.
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song   +5 more
doaj   +1 more source

Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys1

Journal of Lipid Research, 2010
Accumulation of cholesterol in arterial macrophages may contribute to diabetes-accelerated atherosclerotic cardiovascular disease. The ATP-binding cassette transporter ABCA1 is a cardioprotective membrane protein that mediates cholesterol export from ...
Chongren Tang, Jenny E. Kanter, Karin E. Bornfeldt, Renee C. Leboeuf, John F. Oram   +4 more
doaj   +1 more source

Activation of ATP-Binding Cassette Transporter A1 Transcription by Chromatin Remodeling Complex [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Objective— Liver X receptor (LXR) regulates the transcription of ATP-binding cassette transporter A1 (ABCA1) by binding to the DR-4 promoter element as a heterodimer with retinoid X receptor (RXR). The role of chromatin remodeling complex in LXR or ABCA1 activation has not been established previously.
Jarkko, Huuskonen, Meeta, Vishnu, Phoebe E, Fielding, Christopher J, Fielding   +3 more
openaire   +2 more sources

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells

Journal of Lipid Research, 2008
ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor HDL and maintains cellular lipid homeostasis.
Vijay Paul, Heinrich H.D. Meyer, Katharina Leidl, Soni Soumian, Christiane Albrecht   +4 more
doaj   +1 more source

ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]

, 2002
Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van, Zwiers, L.H., Stergiopoulos, I., Waard, M.A., De, Lute-harm Zwiers, Johannes G. M. Van Nistelrooy, Van Nistelrooy, Maarten A. De Waard, Johannes G. M, Ioannis Stergiopoulos   +9 more
core   +1 more source

ATP-Binding Cassette Transporter A1 in Lipoprotein Metabolism and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
ATP-binding cassette transporter A1 (ABCA1) is a key protein determining high-density lipoprotein (HDL) function. In 1999, it was discovered by 3 independent groups that mutations in the gene for ABCA1 underlie the molecular defect in the HDL deficiency syndrome Tangier disease.
Miranda, Van Eck, Theo J C, Van Berkel
openaire   +2 more sources

Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells

Journal of Lipid Research, 2003
Adipose cells specialized in energy storage, contain large intracellular triglyceride-rich lipid droplets, are enriched with free cholesterol, and express sterol-regulated transcription factors such as liver X receptor (LXR). The recent identification of
Soazig Le Lay, Céline Robichon, Xavier Le Liepvre, Georges Dagher, Pascal Ferre, Isabelle Dugail   +5 more
doaj   +1 more source