Results 21 to 30 of about 26,719 (220)

ABCA1 is an extracellular phospholipid translocase

Nature Communications, 2022
ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke   +6 more
doaj   +1 more source

Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives

Cardiovascular Therapeutics, 2022
Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu, Zikai Song, Bao Mao, Guoliang Xu   +3 more
doaj   +1 more source

ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol [PDF]

Journal of Biological Chemistry, 2001
Alpha-tocopherol (alpha-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting alpha-TOH between tissues. Here we show that secretion of alpha-TOH from cultured cells is mediated in part by ABCA1, an ATP-binding cassette protein that transports cellular
J F, Oram, A M, Vaughan, R, Stocker
openaire   +2 more sources

Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner

Journal of Lipid Research, 2006
Serum amyloid A (SAA) is an amphiphilic helical protein that is found associated with plasma HDL in various pathological conditions, such as acute or chronic inflammation. Cellular lipid release and generation of HDL by this protein were investigated, in
Sumiko Abe-Dohmae, Koichi H. Kato, Yoshitaka Kumon, Wei Hu, Hideaki Ishigami, Noriyuki Iwamoto, Mitsuyo Okazaki, Chen-Ai Wu, Maki Tsujita, Kazumitsu Ueda, Shinji Yokoyama   +10 more
doaj   +1 more source

Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor α Expression

Frontiers in Aging Neuroscience, 2021
Abnormal amyloid beta (Aβ) clearance is a distinctive pathological mechanism for Alzheimer’s disease (AD). ATP-binding cassette transporter A1 (ABCA1), which mediates the lipidation of apolipoprotein E, plays a critical role in Aβ clearance.
Dongmei Wu, Yang Hu, Min Song, Gongbo Li
doaj   +1 more source

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Karl-Peter Hopfner, Roy
core   +1 more source

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Journal of Lipid Research, 2006
Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor
Ashley M. Vaughan, John F. Oram
doaj   +1 more source

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core   +4 more sources

Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7

Journal of Lipid Research, 2005
The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected.
Michi Hayashi, Sumiko Abe-Dohmae, Mitsuyo Okazaki, Kazumitsu Ueda, Shinji Yokoyama   +4 more
doaj   +1 more source

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources