ATP-binding cassette transporter A1: from metabolism to neurodegeneration. [PDF]
Neurobiol Dis, 2014 ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport - a role that determines its importance for atherosclerosis.
Koldamova R, Fitz NF, Lefterov I.
europepmc +6 more sources
A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. [PDF]
PLoS One, 2011 Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, the effect of ApoE on the expression of ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective of this study was to determine the effect of ApoE on ApoB-carrying lipoprotein-induced expression of ABCA1, a protein that mediates cholesterol ...
Zhao Y +5 more
europepmc +5 more sources
ATP-binding cassette transporter A1 expression is decreased in preeclamptic placentas. [PDF]
Reprod Sci, 2013 Preeclampsia is a pregnancy-specific multisystem disorder characterized by hypertension and proteinuria. Accentuated maternal hyperlipidemia, especially high serum levels of oxidized low-density lipoprotein (oxLDL), is one of the features of preeclampsia.
Chigusa Y +8 more
europepmc +4 more sources
Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function [PDF]
Circulation Research, 2009 ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotein A-I. However, how ABCA1 targeting to these specific membranes is regulated remains unknown.
Michael R Hayden +2 more
exaly +3 more sources
ATP-binding cassette transporter A1: A promising therapy target for prostate cancer. [PDF]
Mol Clin Oncol, 2018 ATP-binding cassette transporter A1 (ABCA1) has been found to mediate the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I (apoA-I), and is essential for the synthesis of high-density lipoprotein. Mutations of the ABCA1 gene may induce Tangier disease and familial hypoalphalipoproteinemia; they may also lead to loss of ...
Xiong T +6 more
europepmc +4 more sources
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration. [PDF]
Biochim Biophys Acta, 2010 ATP-binding cassette transporter A1 - ABCA1, is the most extensively studied transporter in human pathology. ABCA1 became a primary subject of research in many academic and pharmaceutical laboratories immediately after the discovery that mutations at the gene locus cause severe familial High Density Lipoprotein (HDL) deficiency and, in the homozygous ...
Koldamova R, Fitz NF, Lefterov I.
europepmc +4 more sources
Identification of dehydroxytrichostatin A as a novel up-regulator of the ATP-binding cassette transporter A1 (ABCA1). [PDF]
Molecules, 2011 The ATP-binding cassette transporter A1 (ABCA1) mediates the cellular efflux of excess cholesterol and phospholipids to lipid-poor apolipoprotein A-I (apoA-I). ABCA1 plays an important role in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport.
Xu Y, Xu Y, Bao Y, Hong B, Si S.
europepmc +5 more sources
Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. [PDF]
J Biol Chem, 2011 ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound protein that regulates the efflux of cholesterol derived from internalized lipoproteins. Using a mouse macrophage cell line, this report studied the impact of low-density lipoproteins (LDL) on ABCA1 expression and the signaling pathway responsible for lipoprotein-induced ABCA1 expression ...
Chen X +5 more
europepmc +4 more sources
ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol [PDF]
Journal of Biological Chemistry, 2001 Alpha-tocopherol (alpha-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting alpha-TOH between tissues. Here we show that secretion of alpha-TOH from cultured cells is mediated in part by ABCA1, an ATP-binding cassette protein that transports cellular
J F, Oram, A M, Vaughan, R, Stocker
openaire +2 more sources
Activation of ATP-Binding Cassette Transporter A1 Transcription by Chromatin Remodeling Complex [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— Liver X receptor (LXR) regulates the transcription of ATP-binding cassette transporter A1 (ABCA1) by binding to the DR-4 promoter element as a heterodimer with retinoid X receptor (RXR). The role of chromatin remodeling complex in LXR or ABCA1 activation has not been established previously.
Jarkko, Huuskonen +3 more
openaire +2 more sources