Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. [PDF]
PLoS ONE, 2014 Hepatitis C virus (HCV) establishes infection using host lipid metabolism pathways that are thus considered potential targets for indirect anti-HCV strategies.
Simone Bocchetta +16 more
doaj +13 more sources
ATP-binding cassette transporter A1: From metabolism to neurodegeneration [PDF]
Neurobiology of Disease, 2014 ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport — a role ...
Radosveta Koldamova +2 more
doaj +5 more sources
Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang +9 more
doaj +7 more sources
Functional characterization of genetic variants affecting the intracellular domains of ATP-binding cassette transporter A1 (ABCA1) [PDF]
Journal of Lipid ResearchThe ATP-binding cassette transporter A1 (ABCA1) effluxes cellular cholesterol and phospholipids to extracellular acceptors, mainly apolipoprotein A1, generating high-density lipoprotein (HDL) particles.
Marianne Teigen +4 more
doaj +2 more sources
A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. [PDF]
PLoS ONE, 2011 Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, the effect of ApoE on the expression of ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective of this study was to determine the effect of
Yanfeng Zhao +5 more
doaj +2 more sources
ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2019 Vinnyfred Vincent,1 Himani Thakkar,1 Sandeep Aggarwal,2 Asit Ranjan Mridha,3 Lakshmy Ramakrishnan,4 Archna Singh1 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 2Department of Surgical Disciplines, All India ...
Vincent V +5 more
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Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians [PDF]
Journal of Diabetes Research, 2015 Background. Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors.
Polin Haghvirdizadeh +6 more
doaj +2 more sources
Role of the irr protein in the regulation of iron metabolism in Rhodobacter sphaeroides [PDF]
, 2012 In Rhizobia the Irr protein is an important regulator for iron-dependent gene expression. We studied the role of the Irr homolog RSP_3179 in the photosynthetic alpha-proteobacterium Rhodobacter sphaeroides.
Klug, Gabriele +2 more
core +11 more sources
ABCA1 is an extracellular phospholipid translocase
Nature Communications, 2022 ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).
Jere P. Segrest +6 more
doaj +1 more source
Cardiovascular Therapeutics, 2022 Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu +3 more
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