Journal of Lipid Research, 2004 Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field +2 more
doaj +1 more source
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Objective— Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study
Cuffe H +9 more
europepmc +2 more sources
ATP-Binding Cassette Transporter A1 in Lipoprotein Metabolism and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013 ATP-binding cassette transporter A1 (ABCA1) is a key protein determining high-density lipoprotein (HDL) function. In 1999, it was discovered by 3 independent groups that mutations in the gene for ABCA1 underlie the molecular defect in the HDL deficiency syndrome Tangier disease.
Miranda, Van Eck, Theo J C, Van Berkel
openaire +2 more sources
ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]
, 2002 Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van +9 more
core +1 more source
A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells
Journal of Lipid Research, 2008 ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor HDL and maintains cellular lipid homeostasis.
Vijay Paul +4 more
doaj +1 more source
Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells
Journal of Lipid Research, 2003 Adipose cells specialized in energy storage, contain large intracellular triglyceride-rich lipid droplets, are enriched with free cholesterol, and express sterol-regulated transcription factors such as liver X receptor (LXR). The recent identification of
Soazig Le Lay +5 more
doaj +1 more source
ATP-binding cassette transporter A1 and HDL metabolism: effects of fatty acids [PDF]
The Journal of Nutritional Biochemistry, 2012 Ample evidence indicates that dietary fatty acids alter the plasma levels of high-density lipoprotein cholesterol (HDL-C). However, the mechanisms underlying the effects of fatty acids still remain elusive. Recent advances in our understanding of ATP-binding cassette transporter A1 (ABCA1) function and regulation have provided a valuable insight into ...
Jiyoung, Lee, Youngki, Park, Sung I, Koo
openaire +2 more sources
ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. [PDF]
, 2007 © 2007 Harland et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Elie Dassa +14 more
core +1 more source
New Strategies to Promote Macrophage Cholesterol Efflux
Frontiers in Cardiovascular Medicine, 2021 The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi +3 more
doaj +1 more source
Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter [PDF]
Journal of Biological Chemistry, 2004 In a previous characterization of the ABCA subfamily of the ATP-binding cassette (ABC) transporters, we identified potential protein kinase 2 (CK2) phosphorylation sites, which are conserved in eukaryotic and prokaryotic members of the ABCA transporters.
Roosbeek, Stein +13 more
openaire +4 more sources