Results 31 to 40 of about 11,680 (184)

Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

Frontiers in Cardiovascular Medicine, 2021
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis.
Yan Liu, Yan Sun, Xuze Lin, Dai Zhang, Chengping Hu, Jinxing Liu, Yong Zhu, Ang Gao, Hongya Han, Meng Chai, Jianwei Zhang, Yujie Zhou, Yingxin Zhao   +12 more
doaj   +1 more source

Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells

Journal of Lipid Research, 2003
Adipose cells specialized in energy storage, contain large intracellular triglyceride-rich lipid droplets, are enriched with free cholesterol, and express sterol-regulated transcription factors such as liver X receptor (LXR). The recent identification of
Soazig Le Lay, Céline Robichon, Xavier Le Liepvre, Georges Dagher, Pascal Ferre, Isabelle Dugail   +5 more
doaj   +1 more source

Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter [PDF]

Journal of Biological Chemistry, 2004
In a previous characterization of the ABCA subfamily of the ATP-binding cassette (ABC) transporters, we identified potential protein kinase 2 (CK2) phosphorylation sites, which are conserved in eukaryotic and prokaryotic members of the ABCA transporters.
Roosbeek, Stein, Peelman, Frank, Verhee, Annick, Labeur, Christine, Caster, Hans, Lensink, Marc, Ciruli, Claudia, Grooten, Johan, Cochet, Claude, Vandekerckliove, Joël, Amoresano, Angela, Chimini, Giovanna, Tavernier, Jan, Rosseneu, Maryvonne   +13 more
openaire   +4 more sources

Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

Journal of Pharmacological Sciences, 2011
.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation.
Takashi Maejima, Tomohiro Sugano, Hiroyuki Yamazaki, Yasunobu Yoshinaka, Takeshi Doi, Sohei Tanabe, Tomoko Nishimaki-Mogami   +6 more
doaj   +1 more source

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis

Journal of Lipid Research, 2007
It is well accepted that both apolipoprotein A-I (apoA-I) and ABCA1 play crucial roles in HDL biogenesis and in the human atheroprotective system. However, the nature and specifics of apoA-I/ABCA1 interactions remain poorly understood.
Houssein Hajj Hassan, Maxime Denis, Dong-Young Donna Lee, Iulia Iatan, Dana Nyholt, Isabelle Ruel, Larbi Krimbou, Jacques Genest   +7 more
doaj   +1 more source

Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1

Journal of Lipid Research, 2006
ABCA1 mediates the transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Apolipoprotein A-I (apoA-I) interactions with ABCA1-expressing cells elicit several responses, including removing cellular lipids, stabilizing ABCA1 protein ...
Chongren Tang, Ashley M. Vaughan, G.M. Anantharamaiah, John F. Oram   +3 more
doaj   +1 more source

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDLs⃞

Journal of Lipid Research, 2007
HDL promotes cholesterol efflux from peripheral cells via ABCA1 in the first step of reverse cholesterol transport (RCT). We investigated whether the early steps of RCT were disturbed in subjects with familial low HDL and an increased risk for early ...
Aino Soro-Paavonen, Jussi Naukkarinen, Miriam Lee-Rueckert, Hiroshi Watanabe, Elina Rantala, Sanni Soderlund, Anne Hiukka, Petri T. Kovanen, Matti Jauhiainen, Leena Peltonen, Marja-Riitta Taskinen   +10 more
doaj   +1 more source

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker‐Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg   +10 more
doaj   +1 more source

Phosphorylation and Stabilization of ATP Binding Cassette Transporter A1 by Synthetic Amphiphilic Helical Peptides [PDF]

Journal of Biological Chemistry, 2004
To investigate structural requirement of helical apolipoprotein to phosphorylate and stabilize ATP-binding cassette transporter A1 (ABCA1), synthetic peptides (Remaley, A. T., Thomas, F., Stonik, J. A., Demosky, S. J., Bark, S. E., Neufeld, E. B., Bocharov, A. V., Vishnyakova, T. G., Patterson, A. P., Eggerman, T.
Reijiro, Arakawa, Michi, Hayashi, Alan T, Remaley, Bryan H, Brewer, Yoshio, Yamauchi, Shinji, Yokoyama   +5 more
openaire   +2 more sources