Results 1 to 10 of about 1,912,571 (214)

Circ_ASPH promotes cholangiocarcinoma growth and metastasis through the miR‐581/ATP‐binding cassette transporter G1 signaling pathway [PDF]

Cancer Communications, 2020
Yi Xu, Pengcheng Kang, Kaiming Leng, Yue Yao, Guanqun Liao, Yi Han, Guangjun Shi, Xiangyu Zhong, Yunfu Cui   +8 more
doaj   +5 more sources

Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients

Frontiers in Pharmacology, 2021
Objective: It has been reported that atrial natriuretic peptide (ANP) regulates lipid metabolism by stimulating adipocyte browning, lipolysis, and lipid oxidation, and by impacting the secretion of adipokines.
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song   +5 more
doaj   +1 more source

Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

Frontiers in Cardiovascular Medicine, 2021
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis.
Yan Liu, Yan Sun, Xuze Lin, Dai Zhang, Chengping Hu, Jinxing Liu, Yong Zhu, Ang Gao, Hongya Han, Meng Chai, Jianwei Zhang, Yujie Zhou, Yingxin Zhao   +12 more
doaj   +1 more source

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Journal of Lipid Research, 2006
Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor
Ashley M. Vaughan, John F. Oram
doaj   +1 more source

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

Journal of Lipid Research, 2015
In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and ...
Hao Wei, Elizabeth J. Tarling, Timothy S. McMillen, Chongren Tang, Renée C. LeBoeuf   +4 more
doaj   +1 more source

The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Biomedicines, 2021
Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality.
Marina Canyelles, Álvaro García-Osuna, Alexandra Junza, Oscar Yanes, Núria Puig, Jordi Ordóñez-Llanos, Alessandro Sionis, Jordi Sans-Roselló, Aitor Alquézar-Arbé, David Santos, Noemi Rotllan, Josep Julve, Mireia Tondo, Joan Carles Escolà-Gil, Francisco Blanco-Vaca   +14 more
doaj   +1 more source

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner

Journal of Lipid Research, 2009
Mammalian spermatozoa undergo important plasma membrane maturation steps during epididymal transit. Among these, changes in lipids and cholesterol are of particular interest as they are necessary for fertilization.
Aurélia Ouvrier, Rémi Cadet, Patrick Vernet, Brigitte Laillet, Jean-Michel Chardigny, Jean-Marc A. Lobaccaro, Joël R. Drevet, Fabrice Saez   +7 more
doaj   +1 more source

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

Journal of Lipid Research, 2015
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy.
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton   +9 more
doaj   +1 more source

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +1 more source