Results 41 to 50 of about 1,912,571 (214)

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins [PDF]

Proceedings of the National Academy of Sciences, 2004
The mechanisms responsible for the inverse relationship between plasma high-density lipoprotein (HDL) levels and atherosclerotic cardiovascular disease are poorly understood. The ATP-binding cassette transporter A1 (ABCA1) mediates efflux of cellular cholesterol to lipid-poor apolipoproteins but not to HDL particles that constitute the bulk of plasma ...
Nan, Wang, Debin, Lan, Wengen, Chen, Fumihiko, Matsuura, Alan R, Tall   +4 more
openaire   +2 more sources

E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro

Acta Pharmaceutica Sinica B, 2016
Liver X receptor (LXR) plays an important role in reverse cholesterol transport (RCT), and activation of LXR could reduce atherosclerosis. In the present study we used a cell-based screening method to identify new potential LXRβ agonists.
Ni Li, Xiao Wang, Peng Liu, Duo Lu, Wei Jiang, Yanni Xu, Shuyi Si   +6 more
doaj   +1 more source

ABCG1 rs57137919G>a polymorphism is functionally associated with varying gene expression and apoptosis of macrophages. [PDF]

PLoS ONE, 2014
ATP-binding cassette transporter G1 (ABCG1) is a transmembrane cholesterol transporter involved in macrophage sterol homeostasis, reverse cholesterol transport (RCT), and atherosclerosis.
Fang Liu, Wei Wang, Yan Xu, Yu Wang, Lian-Feng Chen, Quan Fang, Xiao-Wei Yan   +6 more
doaj   +1 more source

Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles

Journal of Pharmaceutical Analysis
Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic and medical fields. However, this drug faces a series of challenges when used to treat atherosclerosis caused by hyperhomocysteinemia (HHcy ...
Dayue Liu, Anning Yang, Yulin Li, Zhenxian Li, Peidong You, Hongwen Zhang, Shangkun Quan, Yue Sun, Yaling Zeng, Shengchao Ma, Jiantuan Xiong, Yinju Hao, Guizhong Li, Bin Liu, Huiping Zhang, Yideng Jiang   +15 more
doaj   +1 more source

ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

Journal of Lipid Research, 2007
Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung.
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio   +8 more
doaj   +1 more source

Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells

Frontiers in Oncology, 2018
The ATP-binding cassette transporter G1 (ABCG1) is a cholesterol lipid efflux pump whose role in tumor growth has been largely unknown. Our transcriptomics revealed that ABCG1 was powerfully expressed in rapidly metastatic, aggregative colon cancer cells,
Yuri Namba, Yuri Namba, Chiharu Sogawa, Yuka Okusha, Hotaka Kawai, Mami Itagaki, Kisho Ono, Jun Murakami, Jun Murakami, Eriko Aoyama, Kazumi Ohyama, Jun-ichi Asaumi, Masaharu Takigawa, Kuniaki Okamoto, Stuart K. Calderwood, Ken-ichi Kozaki, Takanori Eguchi, Takanori Eguchi   +17 more
doaj   +1 more source

ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose [PDF]

Heart, 2011
Introduction It is known that hyperglycaemia can contribute to defects in endothelial function, which is the early characteristic of atherosclerosis. ATP-binding cassette transporter G1 (ABCG1), a regulator of reversing cholesterol efflux, is highly expressed in endothelial cells.
Xue Jiahong, Zhu Canzhan, Dang Yinhu, Li Yongqin, Gao Dengfeng, Niu Xiaolin   +5 more
openaire   +1 more source

Structure of WbdD : a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a [PDF]

, 2012
The Escherichia coli serotype O9a O-antigen polysaccharide (O-PS) is a model for glycan biosynthesis and export by the ATP-binding cassette transporter-dependent pathway.
James H. Naismith, Gregor Hagelueken, Bradley R. Clarke, Hagelueken, Gregor, Huang, Hexian, Chris Whitfield, Clarke, Bradley R., Whitfield, Chris, Tomas Lebl, Lebl, Tomas, Naismith, James H., Hexian Huang, Lebl, Tomas; id_orcid   +12 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source