Results 61 to 70 of about 1,912,571 (214)
Fingerprint of the mitochondrial ABC transporter Mdl1p from Saccharomyces cerevisiae [PDF]
, 2006 The multidrug resistance like protein 1 (Mdl1p) belongs to the class of ATP binding cassette (ABC) transporters which comprise a large family of membrane proteins utilising ATP hydrolysis to drive up-hill transport of a wide variety of solutes across ...
Hofacker, Matthias
core
Journal of Lipid Research, 2009 Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content by inducing reverse cholesterol transport, increasing bile acid production, and inhibiting ...
Adelheid Kratzer +21 more
doaj +1 more source
What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
Biotechnology and Bioengineering, EarlyView.Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady +6 more
wiley +1 more source
Mechanistic insights into ATP hydrolysis by the ABC transporter TAP [PDF]
, 2004 The transporter associated with antigen processing (TAP) plays a pivotal role in the adaptive immune response against virus-infected or malignantly transformed cells.
Chen, Min
core
Bone marrow‐like viscosity affects imatinib resistance in chronic myeloid leukemia
Biotechnology Progress, EarlyView.Physical cues such as microenvironmental viscosity have been recognized as important regulators in controlling cell functions. However, even though the bone marrow (BM) is a viscous tissue in which cells respond mechanically to both the matrix stiffness and the viscosity of surrounding fluid, the impact of microenvironmental viscosity on imatinib (IM ...
Tianjiao Zeng +6 more
wiley +1 more source
Solid-state NMR Reveals Asymmetric ATP hydrolysis in the Multidrug ABC Transporter BmrA [PDF]
, 2022 The detailed mechanism of ATP hydrolysis in ATP-binding cassette (ABC) transporters is still not fully understood. Here, we employed 31P solid-state NMR to probe the conformational changes and dynamics during the catalytic cycle by locking the multidrug ...
Denis, Lacabanne +15 more
core +2 more sources
Investigation of the Function and Regulation of ABC Transporters [PDF]
, 2014 The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorATP-Binding-Cassette (ABC) transporters are primary active pumps that typically ...
Akkaya, Begum Gokcen
core +1 more source
Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1[S]
Journal of Lipid Research, 2014 Accumulation of foam cells in the neointima represents a key event in atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), a lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis ...
Zhiping Liu +10 more
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley +1 more source