Results 1 to 10 of about 471,843 (117)

Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy [PDF]

Frontiers in Pharmacology
BackgroundThis study was aimed at identifying the effects of liver X receptor alpha (LXRα) on sepsis-induced acute lung injury (ALI) and clarifying its novel regulatory mechanisms using bioinformatics and experimental methods.MethodsBioinformatics ...
Ben Wang, Ran Wang, Xueling Wu, Yu Zhong, Chaowang Huang, Zhi Xu, Liang Guo   +6 more
doaj   +2 more sources

Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR) [PDF]

Foods, 2023
Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in ...
J. Abraham Domínguez-Avila
doaj   +2 more sources

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor

Frontiers in Pharmacology, 2022
Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals.
Jianglian She, Jianglian She, Tanwei Gu, Xiaoyan Pang, Yonghong Liu, Yonghong Liu, Yonghong Liu, Lan Tang, Xuefeng Zhou, Xuefeng Zhou   +9 more
doaj   +1 more source

Development of Agonist-Based PROTACs Targeting Liver X Receptor

Frontiers in Chemistry, 2021
Liver X receptors (LXRs) belong to the nuclear hormone receptor superfamily and function as ligand-dependent transcription factors that regulate cholesterol homeostasis, lipid homeostasis, and immune responses.
Hanqiao Xu, Hanqiao Xu, Nobumichi Ohoka, Hidetomo Yokoo, Kanako Nemoto, Takashi Ohtsuki, Hiroshi Matsufuji, Mikihiko Naito, Takao Inoue, Genichiro Tsuji, Yosuke Demizu, Yosuke Demizu   +11 more
doaj   +1 more source

The ameliorating effect of withaferin A on high-fat diet-induced non-alcoholic fatty liver disease by acting as an LXR/FXR dual receptor activator

Frontiers in Pharmacology, 2023
Introduction: Non-alcoholic fatty liver disease (NAFLD) incidence has been rapidly increasing, and it has emerged as one of the major diseases of the modern world.
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Lakshana D. Puttahanumantharayappa, Shreyas H. Karunakara, Smitha Bhat, Shashanka K. Prasad, Shashanka K. Prasad, Divya P. Kumar, Prasanna K. Santhekadur   +8 more
doaj   +1 more source

Role of Liver X Receptor in AD Pathophysiology. [PDF]

PLoS ONE, 2015
Alzheimer's disease (AD) is the major cause of dementia worldwide. The pharmacological activation of nuclear receptors (Liver X receptors: LXRs or Retinoid X receptors: RXR) has been shown to induce overexpression of the ATP-Binding Cassette A1 (ABCA1 ...
Adrián G Sandoval-Hernández, Luna Buitrago, Herman Moreno, Gloria Patricia Cardona-Gómez, Gonzalo Arboleda   +4 more
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Curcumin ameliorates lipid metabolic disorder and cognitive dysfunction via the ABCA1 transmembrane transport system in APP/PS1 double transgenic mice

Journal of Integrative Neuroscience, 2021
The disorder of lipid metabolism, especially cholesterol metabolism, can promote Alzheimer’s Disease. Curcumin can ameliorate lipid metabolic disorder in the brain of Alzheimer’s Disease patients, while the mechanism is not clear.
Mingyuan Tian, Fanlin Zhou, Zhipeng Teng, Chen Wang, Xiong Zhang, Yangyang Wang, Yu Li   +6 more
doaj   +1 more source

LXRs: The Key Regulators of Intermediary Metabolism in Metabolic Syndrome [PDF]

Reviews in Clinical Medicine, 2017
Metabolic syndrome and its various manifestations are considered to be a significant health epidemic in the developed and developing countries across the world.
Hassan Mehrad-Majd, Javad Akhtari, Yalda Ravanshad   +2 more
doaj   +1 more source

High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway[S]

Journal of Lipid Research, 2013
Long-chain acyl-CoA synthetases (ACSL) play key roles in fatty acid metabolism in liver and other metabolic tissues in an isozyme-specific manner. In this study, we examined the effects of a fructose-enriched diet on expressions of ACSL isoforms in the ...
Bin Dong, Chin Fung Kelvin Kan, Amar B. Singh, Jingwen Liu   +3 more
doaj   +1 more source

Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors

Journal of Pharmacological Sciences, 2005
Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj   +1 more source