Results 41 to 50 of about 789,953 (305)

Newly-found functions of metformin for the prevention and treatment of age-related macular degeneration [PDF]

International Journal of Ophthalmology, 2021
Metformin (MET), a first-line oral agent used to treat diabetes, exerts its function mainly by activating adenosine monophosphate-activated protein. The accumulation of oxidized phospholipids in the outer layer of the retina plays a key role in retinal ...
Kuan-Rong Dang, Tong Wu, Yan-Nian Hui, Hong-Jun Du   +3 more
doaj   +1 more source

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

Pregnane X receptor in drug-induced liver injury: Friend or foe?

Liver Research, 2018
The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj   +1 more source

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.

PLoS ONE, 2015
Liver grafts donated after cardiac death are increasingly used to expand the donor pool but are prone to ischaemic-type biliary lesions. The anti-inflammatory effects of the activated pregnane X receptor have previously been shown to be beneficial in a ...
Aimen O Amer, Philip M Probert, Michael Dunn, Margaret Knight, Abigail E Vallance, Paul A Flecknell, Fiona Oakley, Iain Cameron, Steven A White, Peter G Blain, Matthew C Wright   +10 more
doaj   +1 more source

Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cholestasis is the major cause of the accumulation of bile acids and results in liver damage, fibrosis, and failure. A growing number of studies have shown that gentiopicroside is a promising prospect that may protect the liver. However,
Han Han, Lili Xu, Kai Xiong, Tong  Zhang, Zhengtao Wang   +4 more
doaj   +1 more source

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

Frontiers in Pharmacology, 2021
The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid (BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH).
Ines L. Paraiso, Ines L. Paraiso, Thai Q. Tran, Armando Alcazar Magana, Armando Alcazar Magana, Armando Alcazar Magana, Payel Kundu, Jaewoo Choi, Claudia S. Maier, Gerd Bobe, Gerd Bobe, Jacob Raber, Jacob Raber, Jacob Raber, Chrissa Kioussi, Jan F. Stevens, Jan F. Stevens   +16 more
doaj   +1 more source

Liver X Receptors in Atherosclerosis and Inflammation [PDF]

Circulation Research, 2011
Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key regulators of lipid metabolism and transport but also suppress inflammatory signaling in macrophages through a unique mechanism of transrepression. In this brief review, we focus on the regulatory actions of LXR primarily in macrophages responding to a ...
Seung-Soon, Im, Timothy F, Osborne
openaire   +2 more sources

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular ...
Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Wen Li, Shenming Wang   +9 more
doaj   +1 more source