Liver X Receptors and Male (In)fertility [PDF]
International Journal of Molecular Sciences, 2019 Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously.
Sheba Jarvis +2 more
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Deficiency of Capicua disrupts bile acid homeostasis [PDF]
, 2018 Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N +12 more
core +2 more sources
Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]
, 2017 Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi +17 more
core +2 more sources
A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice [PDF]
, 2016 Background: Fish currently supplies only 40% of the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) required to allow all individuals globally to meet the minimum intake recommendation of 500 mg/d.
Betancor, Monica B +11 more
core +2 more sources
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
doaj +1 more source
Maternal hepatic growth response to pregnancy in the mouse [PDF]
, 2011 Pregnancy is characterized by physiological adjustments in the maternal compartment. In this investigation, the influence of pregnancy on maternal liver was examined in CD-1 mice.
Bao, Qi +6 more
core +1 more source
Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
Acta Pharmaceutica Sinica B, 2015 The liver is unique in regenerative potential, which could recover the lost mass and function after injury from ischemia and resection. The underlying molecular mechanisms of liver regeneration have been extensively studied in the past using the partial ...
Guodong Li, Grace L. Guo
doaj +1 more source
Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: blood-brain barrier (BBB) is made of specialized cells that are responsible for theselective passage of substances directed to the brain. The integrated BBB is essential for precisecontrolling of the different substances passage as well as ...
Mahsa Eskandari, Ali Awsat Mellati
doaj +1 more source
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]
, 2016 Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C +12 more
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Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease
PPAR Research, 2009 A growing number of new studies demonstrate that nuclear receptors are involved in the development of alcoholic liver disease (ALD). Ethanol metabolism and RXR/PPAR functions are tightly interconnected in the liver.
Tommaso Mello +2 more
doaj +1 more source