Results 21 to 30 of about 7,990,457 (266)

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration

Acta Pharmaceutica Sinica B, 2015
The liver is unique in regenerative potential, which could recover the lost mass and function after injury from ischemia and resection. The underlying molecular mechanisms of liver regeneration have been extensively studied in the past using the partial ...
Guodong Li, Grace L. Guo
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease

PPAR Research, 2009
A growing number of new studies demonstrate that nuclear receptors are involved in the development of alcoholic liver disease (ALD). Ethanol metabolism and RXR/PPAR functions are tightly interconnected in the liver.
Tommaso Mello, Simone Polvani, Andrea Galli   +2 more
doaj   +1 more source

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells [PDF]

, 2013
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined.
Wei, Yijuan, Hu, Bingfang, Wen Xie, Xie Wen, Zhai Yonggong, Yonggong Zhai, Huang Min, Bingfang Hu, Hu, B, Xie, W, Jun Zhang, Yijuan Wei, Zhai, Yonggong, Xie, Wen, Min Huang, Zhang Jun, Hu Bingfang, Huang, M, Huang, Min, Wei Yijuan, Zhang, Jun, Zhang, J, Wei, Y, Zhai, Y   +23 more
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Liver X receptor activation promotes differentiation of regulatory T cells. [PDF]

PLoS ONE, 2017
The nuclear receptor Liver X Receptor (LXR) is a ligand-activated transcription factor that has been implicated in control of chronic inflammation by downregulating pro-inflammatory T cell responses.
Martin Herold, Johanna Breuer, Stephanie Hucke, Percy Knolle, Nicholas Schwab, Heinz Wiendl, Luisa Klotz   +6 more
doaj   +1 more source

Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β ...
Roosa Rahunen, Outi Kummu, Vesa Koivukangas, Heidi Hautajärvi, Jukka Hakkola, Jaana Rysä, Janne Hukkanen   +6 more
doaj   +1 more source

Mechanistic studies of the phenobarbital-type induction of cytochromes P450 : role of AMP-activated protein kinase [PDF]

, 2007
Inside the liver cells there are sophisticated mechanisms that have evolved over millions of years to metabolize toxic substances, many of which are fat-soluble compounds making them difficult for the body to excrete.
Blättler, Sharon
core   +1 more source

Liver X Receptor/Retinoid X Receptor Pathway Plays a Regulatory Role in Pacing‐Induced Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The molecular mechanisms through which high‐demand pacing induce myocardial dysfunction remain unclear. Methods and Results We created atrioventricular block in pigs using dependent right ventricular septal pacing for 6 months ...
Yu‐Sheng Lin, Tzu‐Hao Chang, Chung‐Sheng Shi, Yi‐Zhen Wang, Wan‐Chun Ho, Hsien‐Da Huang, Shih‐Tai Chang, Kuo‐Li Pan, Mien‐Cheng Chen   +8 more
doaj   +1 more source

Elevated endotoxin levels in non-alcoholic fatty liver disease [PDF]

, 2010
Background: Emerging data indicate that gut-derived endotoxin may contribute to low-grade systemic inflammation in insulin resistant states. This study aimed to examine the importance of serum endotoxin and inflammatory markers in non-alcoholic fatty ...
Ashour, E., Steven J Creely, Youssef-Elabd, E., Youssef-Elabd, Elham M., Harte, A., Abdalla, M., Creely, S., Ashour Esmat, da Silva, Nancy F., McTernan Philip G, Mohga S Abdalla, Day, C.P., Day, Christopher Paul, Billyard, T., Burt, Alastair D., Burt Alastair D, Philip G McTernan, Kumar, S., Elham M Youssef-Elabd, da Silva, N.F., Alison L Harte, Burt, A.D., Nancy F da Silva, Amin, Ashraf I., Tripathi, Gyanendra, Sharada, H., Burt, A., McTernan, P. G., Billyard, Thomas, da Silva, N., Harte, A.L., Day Christopher P, Youssef-Elabd Elham M, Tripathi Gyanendra, Alastair D Burt, Sharada, Hayat M., Hayat M Sharada, Kumar Sudhesh, Abdalla Mohga S, Sharada, H.M., Day, C., Abdalla, Mohga S., Sudhesh Kumar, Creely, S.J., McGee Kirsty C, Esmat Ashour, McTernan, P., Abdalla, M.S., Tripathi, G., McGee, K.C., Youssef-Elabd, E.M., Kirsty C McGee, Christopher P Day, Ashour, Esmat, McGee, K., Billyard Thomas, Gyanendra Tripathi, Thomas Billyard, Kumar, Sudhesh, Amin Ashraf I, Amin, A., da Silva Nancy F, Harte, A. L., Ashraf I Amin, McTernan, P.G., Creely, Steven J., McGee, K. C., Harte Alison L, Creely Steven J, Sharada Hayat M, Amin, A.I.   +70 more
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Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of Lipid Research, 2002
Affymetrix microarray data and Northern blot assays demonstrated that phospholipid transfer protein (PL222222222216) was induced 6-fold when either murine or human macrophages were incubated in the presence of ligands for the liver X receptor (LXR) and ...
Puiying A. Mak, Heidi R. Kast-Woelbern, Andrew M. Anisfeld, Peter A. Edwards   +3 more
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Nutrients and genes in the liver: The central role of liver x receptor in lipogenesis

, 2020
Dietary fats are an important energy source, which form an essential part of membranes and function as precursors of important molecules, such as hormones.
Garcia-Irigoyen O., Piccinin E., Moschetta A., Cariello M.   +3 more
core   +1 more source