Results 31 to 40 of about 789,953 (305)

Liver X receptor activation promotes differentiation of regulatory T cells. [PDF]

PLoS ONE, 2017
The nuclear receptor Liver X Receptor (LXR) is a ligand-activated transcription factor that has been implicated in control of chronic inflammation by downregulating pro-inflammatory T cell responses.
Martin Herold, Johanna Breuer, Stephanie Hucke, Percy Knolle, Nicholas Schwab, Heinz Wiendl, Luisa Klotz   +6 more
doaj   +1 more source

Differential Tissue Response to Growth Hormone in Mice [PDF]

, 2018
Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1).
Banerjee, Ronadip R., Berry, Ryan, Frank, Stuart J., McGinnis, Graham R., Young, Martin E.   +4 more
core   +2 more sources

Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β ...
Roosa Rahunen, Outi Kummu, Vesa Koivukangas, Heidi Hautajärvi, Jukka Hakkola, Jaana Rysä, Janne Hukkanen   +6 more
doaj   +1 more source

Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]

, 1989
Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla, A Mode, A Schleusener, AE Pegg, AJ Syms, B Katchen, CL Mendenhall, CW Bardin, D Kahn, DM Cohen, E Bresnidk, E Mezey, E Mezey, E Mezey, EM Higgins, ER Lax, F Neumann, J Simard, J Terblanche, JA Gustafsson, JA Gustafsson, JA McGowan, JH Clark, JM Kissane, JP Blondeau, KE Crow, LE Porter, M Kayfman, M Sarff, MF Zuretti, OH Lowry, PK Eagon, PK Eagon, PK Eagon, R Neri, W Welshons, WJ King   +36 more
core   +1 more source

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]

, 2020
Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D., Bell, J.D., Bligh, S.W.A., Bligh, S.W.A., Katsuno, T., Katsuno, T., Parkinson, J., Parkinson, J., Shinjyo, N., Shinjyo, N.   +9 more
core   +1 more source

Liver X Receptor/Retinoid X Receptor Pathway Plays a Regulatory Role in Pacing‐Induced Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The molecular mechanisms through which high‐demand pacing induce myocardial dysfunction remain unclear. Methods and Results We created atrioventricular block in pigs using dependent right ventricular septal pacing for 6 months ...
Yu‐Sheng Lin, Tzu‐Hao Chang, Chung‐Sheng Shi, Yi‐Zhen Wang, Wan‐Chun Ho, Hsien‐Da Huang, Shih‐Tai Chang, Kuo‐Li Pan, Mien‐Cheng Chen   +8 more
doaj   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K., Hageman, J., Herrema, H.J., Kuipers, F.   +3 more
core   +3 more sources

Liver X receptors regulate cerebrospinal fluid production [PDF]

Molecular Psychiatry, 2015
Of the two isoforms of Liver X receptor (LXR), LXRβ has been shown to have major effects in the central nervous system (CNS) and on the regulation of aquaporins while LXRα has its most marked effects on cholesterol homeostasis. Both receptors have immunomodulatory functions. In LXRαβ knockout (ko) mice, the CNS phenotype is much more severe than in the
Y-B, Dai, W-F, Wu, B, Huang, Y-F, Miao, S, Nadarshina, M, Warner, J-Å, Gustafsson   +6 more
openaire   +2 more sources

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of Lipid Research, 2002
Affymetrix microarray data and Northern blot assays demonstrated that phospholipid transfer protein (PL222222222216) was induced 6-fold when either murine or human macrophages were incubated in the presence of ligands for the liver X receptor (LXR) and ...
Puiying A. Mak, Heidi R. Kast-Woelbern, Andrew M. Anisfeld, Peter A. Edwards   +3 more
doaj   +1 more source