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Farnesoid X receptor (FXR): Structures and ligands

Computational and Structural Biotechnology Journal, 2021
Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved in the metabolic process of bile acid synthesis, transport and ...
Longying Jiang, Huajun Zhang, Desheng Xiao, Hudie Wei, Yongheng Chen   +4 more
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Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. [PDF]

PLoS ONE, 2012
BackgroundFarnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis.
Jessica A Williams, Ann M Thomas, Guodong Li, Bo Kong, Le Zhan, Yuka Inaba, Wen Xie, Wen-Xing Ding, Grace L Guo   +8 more
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Natural Products Targeting Liver X Receptors or Farnesoid X Receptor [PDF]

Frontiers in Pharmacology, 2022
Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals.
Jianglian She, Jianglian She, Tanwei Gu, Xiaoyan Pang, Yonghong Liu, Yonghong Liu, Yonghong Liu, Lan Tang, Xuefeng Zhou, Xuefeng Zhou   +9 more
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Targeting farnesoid X receptor as aging intervention therapy [PDF]

Acta Pharmaceutica Sinica B
Environmental toxicants have been linked to aging and age-related diseases. The emerging evidence has shown that the enhancement of detoxification gene expression is a common transcriptome marker of long-lived mice, Drosophila melanogaster, and ...
Lijun Zhang, Jing Yu, Xiaoyan Gao, Yingxuan Yan, Xinyi Wang, Hang Shi, Minglv Fang, Ying Liu, Young-Bum Kim, Huanhu Zhu, Xiaojun Wu, Cheng Huang, Shengjie Fan   +12 more
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Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling [PDF]

Journal of Advanced Research
Background: Neuropathic pain, is a chronic condition stemming from nervous system injuries. The farnesoid X receptor (FXR), primarily expressed in the liver and intestines, plays a crucial role in regulating bile acids and lipids metabolism.
Jiaqi Lin, Xuejiao Zeng, Zehua Su, Xin Li, Yongze Yu, Shuwen Qian, Qianhao Hou, Wenying Duan, Zetian Wang, Chunzheng Liu, Jinyuan Zhang, Changshun Huang, Lijun Liao   +12 more
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Computational study of novel natural agonists targeting farnesoid X receptor [PDF]

Scientific Reports
The farnesoid X receptor (FXR) is a crucial therapeutic target for treating non-alcoholic steatohepatitis (NASH). Although obeticholic acid (OCA) as a FXR agonist presents good efficacy, the safety data such as severe pruritus should be carefully ...
Xindan Hu, Junliang Ge, Ying Wen
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Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota

Metabolites, 2022
Obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD) are characterized by the concepts of lipo- and glucotoxicity. NAFLD is characterized by the accumulation of different lipidic species within the hepatocytes. Bile acids (BA), derived
Hideki Mori, Gianluca Svegliati Baroni, Marco Marzioni, Francesca Di Nicola, Pierangelo Santori, Luca Maroni, Ludovico Abenavoli, Emidio Scarpellini   +7 more
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Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K., Hageman, J., Herrema, H.J., Kuipers, F.   +3 more
core   +3 more sources

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization

Frontiers in Immunology, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Kunihiro Otsuka, Shin-ichi Tsukumo, Shin-ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +11 more
doaj   +1 more source