Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection. [PDF]
, 2016 Primary biliary cholangitis (PBC), previously known as primary biliary "cirrhosis", is a rare autoimmune liver disease characterized by the hallmark autoantibodies to mitochondrial antigens and immune-mediated destruction of small bile duct epithelial ...
Bowlus, Christopher L
core +3 more sources
DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer
Technology in Cancer Research & Treatment, 2023 Objectives DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.
Yanguang Hou MD +5 more
doaj +1 more source
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA
Computational and Structural Biotechnology Journal, 2023 Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR
Longying Jiang +8 more
doaj +1 more source
Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. [PDF]
, 2017 This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders.
French, Samuel W +8 more
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Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor [PDF]
Endocrinology, 2005 The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that functions as the bile acid receptor. In addition to the critical role FXR plays in bile acid metabolism and transport, it regulates a variety of genes important in lipoprotein metabolism.
Keith R, Stayrook +7 more
openaire +2 more sources
Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists
Diseases, 2020 Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by the progressive destruction of the intrahepatic bile ducts. Currently, the first line drug for PBC is ursodeoxycholic acid (UDCA) characterized by anti-apoptotic ...
Ludovico Abenavoli +6 more
doaj +1 more source
Repurposing drugs to target nonalcoholic steatohepatitis [PDF]
, 2019 Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José +1 more
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Farnesoid X receptor represses hepatic lipase gene expression
Journal of Lipid Research, 2004 The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays a central role in BA, cholesterol, and lipoprotein metabolism.
Audrey Sirvent +7 more
doaj +1 more source
Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis MiceSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19.
Pauline T. Ikpa +7 more
doaj +1 more source
Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]
, 2019 Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José +1 more
core +1 more source