Results 21 to 30 of about 6,800,049 (185)

DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer

Technology in Cancer Research & Treatment, 2023
Objectives DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.
Yanguang Hou MD, Jiachen Liu MD, Shiyu Huang MD, Lei Wang MD, Juncheng Hu PhD, Xiuheng Liu MD, PhD   +5 more
doaj   +1 more source

Regulation of hepatic heme synthesis by drugs, bile acids and nutrition : a transcriptional network regulating [delta]-aminolevulinic acid synthase 1 (ALAS1) [PDF]

, 2008
ALAS1 is the rate limiting enzyme of heme synthesis. It is highly inducible in liver in cases of increased heme demand, such as drug metabolism or in inducible hepatic porphyrias.
Peyer, Anne-Kathrin
core   +1 more source

Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors

Journal of Pharmacological Sciences, 2005
Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj   +1 more source

Farnesoid X receptor: a potential therapeutic target in multiple organs [PDF]

, 2020
Farnesoid X receptor (FXR), a member of the nuclear receptor family, is a common receptor found in the intestine and liver, and helps to maintain systemic metabolic homeostasis through regulating bile acid, glucose, lipid metabolism, and energy ...
Feng, Qingqing, Wang, Yan-Dong, Zhang, Chao, Chen, Wei-Dong, Wang, Zixuan   +4 more
core   +1 more source

Molecular tuning of farnesoid X receptor partial agonism

Nature Communications, 2019
The ligand-activated transcription factor farnesoid X receptor (FXR) acts as a cellular sensor for bile acids and is of interest as a drug target. Here the authors employ X-ray crystallography and NMR to characterize the molecular determinants of FXR ...
Daniel Merk, Sridhar Sreeramulu, Denis Kudlinzki, Krishna Saxena, Verena Linhard, Santosh L. Gande, Fabian Hiller, Christina Lamers, Ewa Nilsson, Anna Aagaard, Lisa Wissler, Niek Dekker, Krister Bamberg, Manfred Schubert-Zsilavecz, Harald Schwalbe   +14 more
doaj   +1 more source

Regulation of bile acid receptor activity

Liver Research, 2018
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
doaj   +1 more source

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19.
Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds   +7 more
doaj   +1 more source

Bile Acids and Their Value for Central Nervous System

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
Aim. A review to highlight the bile acids importance as steroid mediators of nervous system activity and show the nervous system involvement in cholesterol metabolism and bile acids production.Key points.
Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin   +3 more
doaj   +1 more source

Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.

PLoS ONE, 2012
BackgroundFarnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis.
Jessica A Williams, Ann M Thomas, Guodong Li, Bo Kong, Le Zhan, Yuka Inaba, Wen Xie, Wen-Xing Ding, Grace L Guo   +8 more
doaj   +1 more source

Gypenosides ameliorate high-fat diet-induced non-alcoholic steatohepatitis via farnesoid X receptor activation

Frontiers in Nutrition, 2022
BackgroundGypenosides (Gyps), the major botanical component of Gynostemma pentaphyllum, was found to up-regulate the farnesoid X receptor (FXR) in a mouse model of non-alcoholic steatohepatitis (NASH).
Hongshan Li, Hongshan Li, Yingfei Xi, Hongliang Liu, Xin Xin   +4 more
doaj   +1 more source