Results 31 to 40 of about 6,800,049 (185)

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of Lipid Research, 2002
Affymetrix microarray data and Northern blot assays demonstrated that phospholipid transfer protein (PL222222222216) was induced 6-fold when either murine or human macrophages were incubated in the presence of ligands for the liver X receptor (LXR) and ...
Puiying A. Mak, Heidi R. Kast-Woelbern, Andrew M. Anisfeld, Peter A. Edwards   +3 more
doaj   +1 more source

Effect of a Farnesoid X-receptor Agonist on Postprandial Lipemia in Rats Fed a Supraphysiological Fat Dozes

Разработка и регистрация лекарственных средств, 2023
Introduction. One of the most progressive directions of the modern stage of development of biology is the deepening of knowledge about the mechanisms of regulation of metabolic processes, in particular about signal molecules that transmit information to ...
Yu. N. Alekhin, O. S. Popova, V. S. Ponamarev, P. A. Parshin   +3 more
doaj   +1 more source

New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]

, 2013
This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
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Aquaporin-8 ameliorates hepatic steatosis through farnesoid X receptor in obese mice

iScience, 2023
Summary: Aquaporin-8(AQP8), is a transmembrane channel protein that abounds in liver, which mainly promotes water transport, modulating bile acid formation. However, its role in hepatic lipid metabolism remains unclear.
Minqi Xiang, Xu Qian, Luyu Han, Hui Wang, Jiqiu Wang, Weiren Liu, Yanyun Gu, Shuangshuang Yao, Jian Yang, Yifei Zhang, Ying Peng, Zhiguo Zhang   +11 more
doaj   +3 more sources

Nonacidic Farnesoid X Receptor Modulators

, 2017
As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. Clinical results have validated FXR as therapeutic target in hepatic and metabolic diseases. To date,
Heering, Jan, Sun-Yee Cheung, Wurglics, Mario, Lüddens, Hartmut, Markus Hartmann, Lindner, Mara, Jan Kramer, Lüddens-Dämgen, Kerstin, Mara Lindner, Gabler, Matthias, Ewgenij Proschak, Mario Wurglics, Hartmann, Markus, Christina Lamers, Hartmut Lüddens, Proschak, Ewgenij, Jurema Schmidt, Lamers, Christina, Heitel, Pascal, Astrid Kaiser, Schubert-Zsilavecz, Manfred, Manfred Schubert-Zsilavecz, Kerstin Lüddens-Dämgen, Merk, Daniel, Cheung, Sun-Yee, Schmidt, Jurema, Daniel Flesch, Daniel Merk, Flesch, Daniel, Kaiser, Astrid, Matthias Gabler, Jan Heering, Pascal Heitel, Kramer, Jan   +33 more
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Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration

Acta Pharmaceutica Sinica B, 2015
The liver is unique in regenerative potential, which could recover the lost mass and function after injury from ischemia and resection. The underlying molecular mechanisms of liver regeneration have been extensively studied in the past using the partial ...
Guodong Li, Grace L. Guo
doaj   +1 more source

Farnesoid X Receptor Agonists as Therapeutic Target for Cardiometabolic Diseases

Frontiers in Pharmacology, 2020
Cardiometabolic diseases are characterized as a combination of multiple risk factors for cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus and dyslipidemia.
Chao Li, Jie Yang, Yu Wang, Yingzi Qi, Wenqing Yang, Yunlun Li, Yunlun Li   +6 more
doaj   +1 more source

Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

, 2023
This is the Supplemental Material associated with the publication Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease.
Bryce Jones (16960698)
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Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

, 2014
BACKGROUND: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis.
Spengler, Ulrich, Langhans, Bettina, Lammert, Frank, Nischalke, Hans Dieter, Hoerauf, Achim, Strassburg, Christian P, Grünhage, Frank, Appenrodt, Beate, Nattermann, Jacob, Berger, Cordula, Lutz, Philipp, Sauerbruch, Tilman   +11 more
core   +1 more source