Results 51 to 60 of about 6,800,049 (185)

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2012
Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura, Yusuke Terada, Takashi Tsujimoto, Takahiro Koizumi, Kaori Kuwayama, Hajime Maruyama, Asuka Fujikawa, Atsushi Takaya, Masaki Kobayashi, Shirou Itagaki, Natsuko Takahashi, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki   +13 more
doaj   +1 more source

The farnesoid X receptor induces very low density lipoprotein receptor gene expression [PDF]

, 2004
The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). In response to ligand-binding, FXR regulates many genes involved in BA, lipid, and lipoprotein metabolism.
Claudel, Thierry, Hum, Dean W., Kosykh, Vladimir, Brozek, John, Thierry Claudel, Martin, Geneviève, Vladimir Kosykh, Jean-Charles Fruchart, Bart Staels, Geneviève Martin, Staels, Bart, Audrey Sirvent, John Brozek, Darteil, Raphaël, Dean W. Hum, Raphaël Darteil, Sirvent, Audrey, Fruchart, Jean-Charles   +17 more
core   +1 more source

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis[S]

Journal of Lipid Research, 2011
Aldo-keto reductase 1B7 (AKR1B7) is proposed to play a role in detoxification of by-products of lipid peroxidation. In this article, we show that activation of the nuclear receptor farnesoid X receptor (FXR) induces AKR1B7 expression in the liver and ...
Xuemei Ge, Liya Yin, Huiyan Ma, Tiangang Li, John Y.L. Chiang, Yanqiao Zhang   +5 more
doaj   +1 more source

Interaction of chosen natural compounds with farnesoid X receptor [PDF]

, 2016
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Mgr. Eliška Trojanová Supervisor: Prof. PharmDr. Petr Pávek, Ph.D.
Trojanová, Eliška
core   +1 more source

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Communications Biology
High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear.
Song Chen, Zongren Hu, Jianbang Tang, Haipeng Zhu, Yuhua Zheng, Jiedong Xiao, Youhua Xu, Yao Wang, Yi Luo, Xiaoying Mo, Yalan Wu, Jianwen Guo, Yongliang Zhang, Huanhuan Luo   +13 more
doaj   +1 more source

Loss of small heterodimer partner expression in the liver protects against dyslipidemias⃞

Journal of Lipid Research, 2009
Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7α-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis.
Helen B. Hartman, KehDih Lai, Mark J. Evans   +2 more
doaj   +1 more source

Bile acids, farnesoid X receptor, atherosclerosis and metabolic control

, 2007
Purpose of review Bile acids are amphiphilic molecules synthesized from cholesterol exclusively in the liver that are essential for effective absorption of dietary fat.
Staels, Bart, Kuipers, Folkert, Stroeve, Johanna H. M., Kuipers, Folkert; id_orcid, Caron, Sandrine   +4 more
core   +1 more source

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

, 2022
S.50-67The nuclear farnesoid X receptor (FXR) and the enzyme soluble epoxide hydrolase (sEH) are validated molecular targets to treat metabolic disorders such as non‐alcoholic steatohepatitis (NASH).
Kaiser, A., Helmstädter, M., Weizel, L., Heitel, P., Horz, M., Hernandez-Olmos, V., Proschak, A., Schierle, S., Hartmann, M., Proschak, E., Schmidt, J., Merk, D.   +11 more
core   +2 more sources