Results 1 to 10 of about 19,651 (118)

Effect of different bile acids on the intestine through enterohepatic circulation based on FXR

Gut Microbes, 2021
Farnesoid X receptor (FXR) is a nuclear receptor for bile acids (BAs) that is widely expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide variety of metabolic pathways (such as glucose, lipid, and sterol metabolism)
Junwei Xiang, Zhengyan Zhang, Hongyi Xie, Chengcheng Zhang, Yan Bai, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su   +8 more
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Mice with humanized FXR ligand-binding domain display distinct metabolic responses upon pharmacological FXR stimulation [PDF]

Journal of Lipid Research
Farnesoid-X-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to humans.
Jinxiao Li, Hilde D. de Vries, Kirill Ustyantsev, Milaine V. Hovingh, Niels L. Mulder, Rick Havinga, Nicolette Huijkman, Sarah Falcone, Krisztina de Bruyn, Ellen Weersing, Niels J. Kloosterhuis, Marieke Smit, Eugene Berezikov, Bart van de Sluis, Henkjan J. Verkade, Folkert Kuipers, Jan Freark de Boer   +16 more
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The Effects of PPAR Agonists on Atherosclerosis and Nonalcoholic Fatty Liver Disease in ApoE−/−FXR−/− Mice [PDF]

Endocrinology and Metabolism, 2021
Background Farnesoid X receptor (FXR), a bile acid–activated nuclear receptor, is a potent regulator of glucose and lipid metabolism as well as of bile acid metabolism.
Yenna Lee, Bo-Rahm Kim, Geun-Hyung Kang, Gwan Jae Lee, Young Joo Park, Haeryoung Kim, Hak Chul Jang, Sung Hee Choi   +7 more
doaj   +1 more source

Improving glucose and lipids metabolism: drug development based on bile acid related targets

Cell Stress, 2021
Bariatric surgery is one of the most effective treatment options for severe obesity and its comorbidities. However, it is a major surgery that poses several side effects and risks which impede its clinical use.
Hanchen Shen, Lili Ding, Mehdi Baig, Jingyan Tian, Yang Wang, Wendong Huang   +5 more
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Bile acid dysmetabolism in inflammatory bowel diseases

Alʹmanah Kliničeskoj Mediciny, 2023
Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in ...
Daria A. Kuznetsova, Sergey V. Lapin, Irina V. Gubonina   +2 more
doaj   +1 more source

Diversification of host bile acids by members of the gut microbiota

Gut Microbes, 2020
Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host hepatocytes synthesize primary bile acids from cholesterol.
Jenessa A. Winston, Casey M. Theriot
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Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells

The Korean Journal of Gastroenterology, 2021
Backgrounds/Aims: PPARγ, farnesoid X receptor (FXR) and CYP7A1 are associated with solubility of bile. This study was performed to understand a mechanism and interactions of statin-induced PPARγ, PGC-1α and HNF-4α related to the statin-induced activation
Jin Lee, Eun Mi Hong, Jang Han Jung, Se Woo Park, Sang Pyo Lee, Dong Hee Koh, Hyun Joo Jang, Sea Hyub Kae   +7 more
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Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice

Frontiers in Pharmacology, 2023
Background: Farnesoid X receptor (FXR) is a key metabolic target of bile acids (BAs) and is also a target for drugs against several liver diseases. However, the contribution of FXR in the pathogenesis of cholestasis is still not fully understood.
Shizhang Wei, Shizhang Wei, Tingting He, Xu Zhao, Manyi Jing, Haotian Li, Lisheng Chen, Ruimao Zheng, Yanling Zhao   +8 more
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Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Frontiers in Molecular Neuroscience, 2022
The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis in peripheral organs. Indeed, enterohepatic-expressed FXR controls metabolic processes (BA, glucose and lipid metabolism, fat mass, body ...
Benjamin Deckmyn, Benjamin Deckmyn, Benjamin Deckmyn, Benjamin Deckmyn, Benjamin Deckmyn, Dorothée Domenger, Dorothée Domenger, Dorothée Domenger, Dorothée Domenger, Chloé Blondel, Chloé Blondel, Chloé Blondel, Chloé Blondel, Sarah Ducastel, Sarah Ducastel, Sarah Ducastel, Sarah Ducastel, Emilie Nicolas, Emilie Nicolas, Emilie Nicolas, Emilie Nicolas, Emilie Dorchies, Emilie Dorchies, Emilie Dorchies, Emilie Dorchies, Emilie Caron, Julie Charton, Julie Charton, Julie Charton, Emmanuelle Vallez, Emmanuelle Vallez, Emmanuelle Vallez, Emmanuelle Vallez, Benoit Deprez, Benoit Deprez, Benoit Deprez, Jean-Sébastien Annicotte, Sophie Lestavel, Sophie Lestavel, Sophie Lestavel, Sophie Lestavel, Anne Tailleux, Anne Tailleux, Anne Tailleux, Anne Tailleux, Christophe Magnan, Christophe Magnan, Bart Staels, Bart Staels, Bart Staels, Bart Staels, Kadiombo Bantubungi, Kadiombo Bantubungi, Kadiombo Bantubungi, Kadiombo Bantubungi   +54 more
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Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis

Molecular Metabolism, 2023
Objective: Obesity is associated with metabolic dysfunction of white adipose tissue (WAT). Activated adipocytes secrete pro-inflammatory cytokines resulting in the recruitment of pro-inflammatory macrophages, which contribute to WAT insulin resistance ...
Hélène Dehondt, Arianna Marino, Laura Butruille, Denis A. Mogilenko, Arielle C. Nzoussi Loubota, Oscar Chávez-Talavera, Emilie Dorchies, Emmanuelle Vallez, Joel Haas, Bruno Derudas, Antonino Bongiovanni, Meryem Tardivel, Folkert Kuipers, Philippe Lefebvre, Sophie Lestavel, Anne Tailleux, David Dombrowicz, Sandrine Caron, Bart Staels   +18 more
doaj   +1 more source