Results 1 to 10 of about 40,710 (290)
Acta Pharmaceutica Sinica B, 2023 Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show limited clinical benefits, without a clear mechanism.
Shuang Cui, Guangji Wang, Haiping Hao
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Effect of different bile acids on the intestine through enterohepatic circulation based on FXR
Gut Microbes, 2021 Farnesoid X receptor (FXR) is a nuclear receptor for bile acids (BAs) that is widely expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide variety of metabolic pathways (such as glucose, lipid, and sterol metabolism)
Chengcheng Zhang, Yan Bai, Hua Cao
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Recent advances on FXR-targeting therapeutics
Molecular and Cellular Endocrinology, 2022 The bile acid receptor FXR has emerged as a bona fide drug target for chronic cholestatic and metabolic liver diseases, ahead of all non-alcoholic fatty liver disease (NAFLD).
Gernot Zöllner +2 more
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FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption
Cell Metabolism, 2021 FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist GSK2324 controls hepatic lipids via reduced absorption and selective decreases in
William D Barshop +2 more
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Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. [PDF]
PLoS ONE, 2012 BackgroundFarnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis.
Jessica A Williams +8 more
doaj +8 more sources
FXR and liver carcinogenesis [PDF]
Acta Pharmacologica Sinica, 2014 Farnesoid X receptor (FXR) is a member of the nuclear receptor family and a ligand-modulated transcription factor. In the liver, FXR has been considered a multi-functional cell protector and a tumor suppressor. FXR can suppress liver carcinogenesis via different mechanisms: 1) FXR maintains the normal liver metabolism of bile acids, glucose and lipids;
Xiong-fei, Huang +2 more
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FXR Regulates Intestinal Cancer Stem Cell Proliferation
Cell, 2019 SUMMARY Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive ...
Eiji Yoshihara +2 more
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FXR in liver physiology: Multiple faces to regulate liver metabolism
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2021 The liver is the central metabolic hub which coordinates nutritional inputs and metabolic outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR in the liver and the intestine.
Martin Wagner
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FXR: a metabolic regulator and cell protector [PDF]
Cell Research, 2008 Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome ...
Yan-Dong Wang +2 more
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Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1‐Glycolysis Signaling Pathway [PDF]
MedCommNeutrophils significantly accumulate within the inflamed intestinal mucosa of patients with inflammatory bowel disease (IBD), where the farnesoid X receptor (FXR) is typically downregulated.
Dengfeng Kang +15 more
doaj +2 more sources