Results 41 to 50 of about 24,047 (218)

Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1. [PDF]

PLoS ONE, 2014
BACKGROUND: Farnesoid X receptor/retinoid X receptor-alpha (FXR/RXRα) is the master transcriptional regulator of bile salt synthesis and transport in liver and intestine.
Martijn O Hoeke, Janette Heegsma, Mark Hoekstra, Han Moshage, Klaas Nico Faber   +4 more
doaj   +1 more source

A Novel SXXLF Motif in the FXR N-Terminal Domain Mediates Coregulator and Interdomain Interactions. [PDF]

Chembiochem
Farnesoid X receptor (FXR)‐N‐terminal domain (NTD) regulates transcriptional activity through interdomain communication with the LBD and is also involved in co‐activator recruitment. The SENLF motif is the first defined functional element within the FXR‐NTD and mediates both NTD–LBD interaction and selective co‐activator engagements to drive NTD ...
Villalona P, Pulahinge T, Yu T, Wenning J, Khan SH, Frisbie CJ, Magafas J, Barbe A, Okafor CD.   +8 more
europepmc   +2 more sources

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Molecules, 2019
The modulators of farnesoid X receptor (FXR), a bile acid receptor, regulate various biological processes including bile acid metabolism, and are associated with the control of fatty liver and osteoporosis.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source

3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism [PDF]

, 2020
Bile acids (BAs) are important signaling molecules acting via the farnesoid X nuclear receptor (FXR) and the membrane G protein-coupled bile acid receptor 1 (GPBAR1).
Stefela, Alzbeta, Drastik, Martin, Kudova, Eva, Kaspar, Miroslav, Pavek, Petr, Hroch, Milos, Hutníková, Miriama, Holas, Ondrej, Smutny, Tomas, Pandey, Amit Vikram, Skoda, Josef, Micuda, Stanislav   +11 more
core   +1 more source

miRNA-382-5p Suppresses the Expression of Farnesoid X Receptor to Promote Progression of Liver Cancer

Cancer Management and Research, 2021
Xiaobo Nie,1 Huiyang Liu,1 Xiaoyun Wei,1 Lanqing Li,1 Linhua Lan,2 Lili Fan,1 Han Ma,1 Lei Liu,1 Yun Zhou,1 Ruifang Hou,1 Wei-Dong Chen1,3 1Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Basic Medical Sciences, People ...
Nie X, Liu H, Wei X, Li L, Lan L, Fan L, Ma H, Liu L, Zhou Y, Hou R, Chen WD   +10 more
doaj  

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosisResearch in context

EBioMedicine, 2018
Background: Hepatocyte is particularly vulnerable to apoptosis, a hallmark of many liver diseases. Although pro-apoptotic mechanisms have been extensively explored, less is known about the hepatocyte-specific anti-apoptotic molecular events and it lacks ...
Hong Wang, Chaoliang Ge, Jiyu Zhou, Yitong Guo, Shuang Cui, Ningning Huang, Tingting Yan, Lijuan Cao, Yuan Che, Qiuling Zheng, Xiao Zheng, Frank J. Gonzalez, Guangji Wang, Haiping Hao   +13 more
doaj   +1 more source

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

Journal of Lipid Research, 2005
The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid homeostasis.
Elyisha A. Hanniman, Gilles Lambert, Tanya C. McCarthy, Christopher J. Sinal   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source