Results 31 to 40 of about 24,047 (218)

The Nuclear Farnesoid X Receptor Reduces p53 Ubiquitination and Inhibits Cervical Cancer Cell Proliferation

Frontiers in Cell and Developmental Biology, 2021
The role of farnesoid X receptor (FXR) in cervical cancer and the underlying molecular mechanism remain largely unknown. Therefore, this study aimed to assess the mechanism of FXR in cervical cancer.
Xiaohua Huang, Bin Wang, Runji Chen, Shuping Zhong, Fenfei Gao, Yanmei Zhang, Yongdong Niu, Congzhu Li, Ganggang Shi   +8 more
doaj   +1 more source

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer. [PDF]

Pharmacol Res Perspect
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Liu J, Sun K, Liu H, Zhu M, Li C, He Y, Qin L.   +6 more
europepmc   +2 more sources

Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway

Clinical and Experimental Gastroenterology, 2023
Meng Xu,1,* Ke Che,1,* Cong Wang,2,* Ya-Ru Chen,1 Meng-Yuan Chen,1 Guang-Lei Zhang,1 Hao Yu,3 Hao-Nan Xu,1 Ya-Bao Li,1 Ping Sheng,1 Hao Chen1 1College of Life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100 ...
Xu M, Che K, Wang C, Chen YR, Chen MY, Zhang GL, Yu H, Xu HN, Li YB, Sheng P, Chen H   +10 more
doaj  

FXR-deficiency confers increased susceptibility to torpor. [PDF]

, 2007
International audienceThe role of the nuclear receptor FXR in adaptive thermogenesis was investigated using FXR-deficient mice. Despite elevated serum bile acid concentrations and increased mRNA expression profiles of thermogenic genes in brown adipose ...
Staels, Bart, Kuipers, Folkert, Bouchaert, Emmanuel, Abdelkarim, Mouaadh, Cariou, Bertrand, Kuipers, Folkert; id_orcid, Caron, Sandrine, Burcelin, Rémy, Burcelin, Rémy, G., Dumont, Julie, Fruchart, Jean-Charles   +10 more
core   +1 more source

FXR mediates ILC-intrinsic responses to intestinal inflammation [PDF]

, 2022
The pleiotropic actions of the Farnesoid X Receptor (FXR) are required for gut health, and reciprocally, reduced intestinal FXR signaling is seen in inflammatory bowel diseases (IBDs).
Annette Atkins, He, Nanhai, Ye Zheng, Downes, Michael, Cayabyab, Fritz, Sally Coulter, Liddle, Christopher, Tang, Qin, Fritz Cayabyab, Tae Gyu Oh, Truitt, Morgan, Paul Medina, Ruth T. Yu, Atkins, Annette, Yuwenbin Li, Zheng, Ye, Mingxiao He, Yu, Ruth T, Medina, Paul, Evans, Ronald M, Oh, Tae Gyu, Ronald M. Evans, Michael Downes, Nanhai He, Morgan Truitt, Ting Fu, Li, Yuwenbin, Coulter, Sally, Fu, Ting, He, Mingxiao, Christopher Liddle, Qin Tang   +31 more
core   +1 more source

Druggable Microbial Metabolism in Cardiovascular Disease: Functional Gut Microbiome Pathways Reshaping Cardiovascular Risk, Biomarkers, and Therapy [PDF]

Studies in Multidisciplinary Medical Research
The cardiovascular microbiome field is undergoing a conceptual consolidation that resembles prior inflection points in lipid biology and inflammation research: the center of gravity is shifting from descriptive association to mechanistic tractability ...
Ashkan Fallahpour Sichani, Maryam Karimian   +1 more
doaj   +1 more source

Optical Control of the Glucocorticoid Receptor Activity With a Photoswitchable Agonist

Angewandte Chemie, EarlyView.
A photoswitchable glucocorticoid receptor agonist enables optical control of receptor activity, achieving picomolar potency and partial agonism that preferentially maintains anti‐inflammatory signaling over canonical transcriptional activation. ABSTRACT Glucocorticoids (GCs) are widely prescribed anti‐inflammatory agents whose clinical utility is ...
Zoe Sessions, Chloé Van Leene, Dorien Clarisse, George Keen, Agnė Šveistytė, Dinahlee Saturnino Guarino, Robert H. Mach, Karolien De Bosscher, Dirk Trauner   +8 more
wiley   +2 more sources

FXR - dimer no CoA

, 2022
MD data for FXR ...
Kronenberger, Thales
core   +1 more source

Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis [PDF]

, 2014
BACKGROUND: Infectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality as a result.
Dep IRAS, Smits, Alexander J J, Ger. T. Rijkers (668759), Louis M A Akkermans, Rian M. Nijmeijer (208613), Marguerite E I Schipper, IRAS RATIA1, van Erpecum, Karel J., Marguerite E. I. Schipper (109505), Rijkers, Ger T., Akkermans, Louis M. A., Alfons B A Kroese, Andreas E. Kremer (668757), Alexander J J Smits, Hein G. Gooszen (120762), Kroese, Alfons B. A., Karel J. van Erpecum (117691), Louis M. A. Akkermans (374582), Nijmeijer, Rian M., Wijmenga, Cisca, Sub IRAS Tox CMT/NTX, Wijmenga, Cisca; id_orcid, Cisca Wijmenga, Alexander J. J. Smits (668756), Rijkers, Ger. T., Risk Assessment of Toxic and Immunomodulatory Agents, Schaap, Frank G., Gooszen, Hein G, André Verheem, Schipper, Marguerite E. I., Nijmeijer, Rian M, Karel J van Erpecum, Alfons B. A. Kroese (668758), Ger T Rijkers, Gooszen, Hein G., Verheem, André, Hein G Gooszen, Schipper, Marguerite E I, Andreas E Kremer, Frank G. Schaap (117684), Kremer, Andreas E., André Verheem (668760), Rian M Nijmeijer, Akkermans, Louis M A, Schaap, Frank G, Smiths, Alexander J. J., Kremer, Andreas E, Rijkers, Ger T, Frank G Schaap, Kroese, A.B., Smits, Alexander J. J., van Erpecum, Karel J, Cisca Wijmenga (32954)   +52 more
core   +6 more sources

Blueberry Extract Alleviates High-fat Diet-induced Abnormalities in Glycolipid Metabolism through the FXR/PI3K/AKT Signaling Pathway

Shipin gongye ke-ji
Objective: This study aimed to investigate the effect of blueberry extract on the regulation of the FXR/PI3K/AKT pathway on glycolipid metabolism. Methods: C57BL-6J mice were fed a high-fat diet to induce an obesity model and were fed with blueberry ...
Lu DENG, Min WANG, Hao WANG, Rulin MA
doaj   +1 more source