Results 31 to 40 of about 40,710 (290)
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +3 more sources
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.
American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020 Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for maintaining whole body cholesterol homeostasis. Bile acids are physiological detergents that absorb, distribute, metabolize and excrete nutrients, drugs and ...
J. Chiang, Jessica M. Ferrell
semanticscholar +1 more source
FXR signaling in the enterohepatic system [PDF]
Molecular and Cellular Endocrinology, 2013 Enterohepatic circulation serves to capture bile acids and other steroid metabolites produced in the liver and secreted to the intestine, for reabsorption back into the circulation and reuptake to the liver. This process is under tight regulation by nuclear receptor signaling.
Tsutomu, Matsubara +2 more
openaire +2 more sources
Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. [PDF]
, 2017 This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders.
French, Samuel W +8 more
core +1 more source
Cell Metabolism, 2020 Hyocholic acid (HCA) and its derivatives are found in trace amounts in human blood but constitute approximately 76% of the bile acid (BA) pool in pigs, a species known for its exceptional resistance to type 2 diabetes.
Xiaojiao Zheng +25 more
semanticscholar +1 more source
SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes [PDF]
Journal of Biological Chemistry, 2013 Small ubiquitin-like modifiers (SUMO) are covalently conjugated to other proteins including nuclear receptors leading to modification of various cellular processes.Ligand-dependent SUMOylation of farnesoid X receptor (FXR) negatively regulates the expression of its target genes.SUMO modification attenuates the capacity of FXR to function as a ...
Natarajan, Balasubramaniyan +3 more
openaire +2 more sources
Oilseeds and fats, crops and lipids, 2020 The consumption of coconut milk has long been regarded as detrimental to cardiovascular health due to its high saturated fatty acid content. Contradictorily, emerging evidences have highlighted that the fatty acids in coconut lipids, which comprise ...
Wong Hong Kin +2 more
doaj +1 more source
Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]
, 2017 Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi +17 more
core +2 more sources
TDG is a novel tumor suppressor of liver malignancies
Molecular & Cellular Oncology, 2020 In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC).
Haider M. Hassan +3 more
doaj +1 more source
Clinical and Experimental Gastroenterology, 2023 Meng Xu,1,* Ke Che,1,* Cong Wang,2,* Ya-Ru Chen,1 Meng-Yuan Chen,1 Guang-Lei Zhang,1 Hao Yu,3 Hao-Nan Xu,1 Ya-Bao Li,1 Ping Sheng,1 Hao Chen1 1College of Life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100 ...
Xu M +10 more
doaj