Results 51 to 60 of about 40,710 (290)

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2015
OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew, Fairlamb, Alan, Foth, Bernado J., Kelner, Anna, Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +3 more sources

FXR mediates ILC-intrinsic responses to intestinal inflammation

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance In addition to promoting lipid and fat-soluble vitamin absorption, bile acids (BAs) function as signaling molecules that coordinate persistent changes in intestinal cells.
T. Fu, Yuwenbin Li, Tae Gyu Oh, Fritz Cayabyab, Nanhai He, Qin Tang, Sally Coulter, Morgan L. Truitt, Paul Medina, Mingxiao He, R. Yu, A. Atkins, Ye Zheng, C. Liddle, M. Downes, Ronald M. Evans   +15 more
semanticscholar   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling

Annals medicus, 2021
Background: Recent evidence indicates that host-gut microbiota crosstalk has nonnegligible effects on host skeletal muscle, yet gut microbiota-regulating mechanisms remain obscure.
Yixuan Qiu, Jiaming Yu, Yi Li, Fan Yang, Huiyuan Yu, Mengjuan Xue, Fan Zhang, Xin Jiang, Xueying Ji, Z. Bao   +9 more
semanticscholar   +1 more source

Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1. [PDF]

PLoS ONE, 2014
BACKGROUND: Farnesoid X receptor/retinoid X receptor-alpha (FXR/RXRα) is the master transcriptional regulator of bile salt synthesis and transport in liver and intestine.
Martijn O Hoeke, Janette Heegsma, Mark Hoekstra, Han Moshage, Klaas Nico Faber   +4 more
doaj   +1 more source

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Nature Medicine, 2018
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis.
Lulu Sun, Cen Xie, Guang Wang, Yuehua Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, XiaoXia Gao, Pupu Ge, Cuihua Liu, K. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, A. Patterson, Xian Wang, F. Gonzalez, Changtao Jiang   +27 more
semanticscholar   +1 more source

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Nature Communications, 2022
Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1 ...
Ying Yan, Zhoumin Niu, Chao Sun, Peng Li, Siyi Shen, Shengnan Liu, Yuting Wu, Chuyu Yun, Tingying Jiao, Sheng Jia, Yuying Li, Zhong-Ze Fang, Lin Zhao, Ji-qiu Wang, Cen Xie, Changtao Jiang, Yan Li, Xiaoyun Feng, Cheng Hu, Jingjing Jiang, H. Ying   +20 more
semanticscholar   +1 more source

FXR, a target for different diseases.

Histology and histopathology, 2008
Great progress has been made in the understanding of the physiological roles of the nuclear receptor farnesoid X receptor (FXR) during the last several years. Roles for FXR were initially identified in the regulation of bile acid, cholesterol, triglyceride, and glucose metabolism.
Wang, Yan-Dong, Chen, Wei-Dong, Huang, Wendong   +2 more
openaire   +3 more sources

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Molecules, 2019
The modulators of farnesoid X receptor (FXR), a bile acid receptor, regulate various biological processes including bile acid metabolism, and are associated with the control of fatty liver and osteoporosis.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source

The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice

Journal of Biological Chemistry, 2022
Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the US, partly due to the increasing incidence of metabolic syndrome, obesity, and type 2 diabetes.
Xiaoxin X. Wang, Cen Xie, Andrew E. Libby, S. Ranjit, Jonathan Levi, K. Myakala, K. Bhasin, Bryce A. Jones, D. Orlicky, Shogo Takahashi, A. Dvornikov, D. Kleiner, S. Hewitt, L. Adorini, J. Kopp, K. Krausz, A. Rosenberg, J. McManaman, C. Robertson, Diana Ir, D. Frank, Yuhuan Luo, F. Gonzalez, Enrico Gratton, Moshe Levi   +24 more
semanticscholar   +1 more source