Results 61 to 70 of about 40,710 (290)

miRNA-382-5p Suppresses the Expression of Farnesoid X Receptor to Promote Progression of Liver Cancer

Cancer Management and Research, 2021
Xiaobo Nie,1 Huiyang Liu,1 Xiaoyun Wei,1 Lanqing Li,1 Linhua Lan,2 Lili Fan,1 Han Ma,1 Lei Liu,1 Yun Zhou,1 Ruifang Hou,1 Wei-Dong Chen1,3 1Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Basic Medical Sciences, People ...
Nie X, Liu H, Wei X, Li L, Lan L, Fan L, Ma H, Liu L, Zhou Y, Hou R, Chen WD   +10 more
doaj  

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosisResearch in context

EBioMedicine, 2018
Background: Hepatocyte is particularly vulnerable to apoptosis, a hallmark of many liver diseases. Although pro-apoptotic mechanisms have been extensively explored, less is known about the hepatocyte-specific anti-apoptotic molecular events and it lacks ...
Hong Wang, Chaoliang Ge, Jiyu Zhou, Yitong Guo, Shuang Cui, Ningning Huang, Tingting Yan, Lijuan Cao, Yuan Che, Qiuling Zheng, Xiao Zheng, Frank J. Gonzalez, Guangji Wang, Haiping Hao   +13 more
doaj   +1 more source

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

Journal of Lipid Research, 2005
The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid homeostasis.
Elyisha A. Hanniman, Gilles Lambert, Tanya C. McCarthy, Christopher J. Sinal   +3 more
doaj   +1 more source

Bile Acids and FXR: Novel Targets for Liver Diseases

Frontiers in Medicine, 2020
Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from cholesterol and have been shown to be essential for lipid homeostasis.
Mary Stofan, G. Guo
semanticscholar   +1 more source

Blueberry Extract Alleviates High-fat Diet-induced Abnormalities in Glycolipid Metabolism through the FXR/PI3K/AKT Signaling Pathway

Shipin gongye ke-ji
Objective: This study aimed to investigate the effect of blueberry extract on the regulation of the FXR/PI3K/AKT pathway on glycolipid metabolism. Methods: C57BL-6J mice were fed a high-fat diet to induce an obesity model and were fed with blueberry ...
Lu DENG, Min WANG, Hao WANG, Rulin MA
doaj   +1 more source

Catalytic chemical vapor deposition synthesis of single- and double-walled carbon nanotubes from α-(Al1−xFex)2O3 powders and self-supported foams [PDF]

, 2009
An investigation of the potential interest of α-alumina–hematite foams, as opposed to powders, as starting materials for the synthesis of carbon nanotubes (CNTs) by catalytic chemical vapor deposition method was performed.
Cordier, Anne, De Grave, Eddy, Gonzaga de Resende, Valdirene, Laurent, Christophe, Peigney, Alain, Weibel, Alicia   +5 more
core   +2 more sources

Non-linear, Finite Frequency Quantum Critical Transport from AdS/CFT

, 2011
Transport at a quantum critical point depends sensitively on the relative magnitudes of temperature, frequency and electric field. Here we used the gauge/gravity correspondence to compute the full temperature and, generally nonlinear, electric field ...
Karch, Andreas, Sondhi, S. L.
core   +1 more source

FXR - monomers

, 2022
MD simulation of ...
openaire   +1 more source

Regulation of N-Myc downstream regulated gene 2 by bile acids [PDF]

, 2017
Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes ...
Donate, Yolanda, Haro Bautista, Diego, Langhi, Cédric, Marrero González, Pedro F., Pedraz Cuesta, Elena, Rodríguez Rubio, Joan Carles   +5 more
core   +1 more source

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

PLoS ONE, 2011
We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and colon of inflammatory bowel disease (IBD) patients in remission ...
Nijmeijer, R.M., Gadaleta, R.M., Mil, S.W.C. van, Bodegraven, A.A. van, Crusius, J.B.A., Dijkstra, G., Hommes, D.W., Jong, D.J. de, Stokkers, P.C.F., Verspaget, H.W., Weersma, R.K., Woude, C.J. van der, Stapelbroek, J.M., Schipper, M.E.I., Wijmenga, C., Erpecum, K.J. van, Oldenburg, B., Dutch Initiative Crohn   +17 more
openaire   +11 more sources