Results 1 to 10 of about 1,660 (124)
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy
Cell Reports, 2023 Summary: The multiple roles of TGR5 in the regulation of glucose metabolism, inflammation, and oxidative stress have drawn attention as therapeutic candidates for diabetes-related kidney disease.
Zhongqiu Liu, Heqing Huang, Zeyuan Lin
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TGR5 expression in normal kidney and renal neoplasms
Diagnostic Pathology, 2018 Background The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines.
Chaohui Lisa Zhao +4 more
doaj +2 more sources
Mechanism of action of the bile acid receptor TGR5 in obesity
Acta Pharmaceutica Sinica BG protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and Takeda G protein-coupled receptor 5 (TGR5) is a member of this family.
Zhengquan Su, Hua Cao, Jiao Guo
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Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model. [PDF]
PLoS ONE, 2017 TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose homeostasis, it is recognized as a key target in treating metabolic diseases.
Takashi Sasaki +9 more
doaj +1 more source
JHEP Reports, 2021 Background & Aims: Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes.
Madeleine Spatz +15 more
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Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Alcohol-associated liver disease (AALD) is one of the most common causes of liver injury and failure. Limited knowledge of the mechanisms underlying AALD impedes the development of efficacious therapies.
Mingjie Fan +15 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and plays a critical role in regulating inflammatory response.
Lifang Zhao +6 more
doaj +1 more source
Discover Oncology, 2022 Background Takeda G protein receptor 5 (TGR5) is widely recognized as a potential drug target for the treatment of metabolic diseases. TGR5 is not only a metabolic regulator, but also has a potential role that participating in developing and progressing ...
Yangyang Lei +9 more
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Molecules, 2021 Taurochenodeoxycholic acid (TCDCA) is one of the main components of bile acids (BAs). TCDCA has been reported as a signaling molecule, exerting anti-inflammatory and immunomodulatory functions.
Youchao Qi +4 more
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Frontiers in Immunology, 2021 Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways ...
Yong Shi +67 more
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