Results 1 to 10 of about 125,332 (300)

GLP-1 RAs for Treating Metabolic Dysfunction-Associated Steatosis Liver Disease: From GLP-1 Discovery to FDA Approval: A Comprehensive Narrative Review [PDF]

Pharmaceuticals
Background: Metabolic dysfunction-associated steatosis liver disease (MASLD), formerly termed nonalcoholic fatty liver disease (NAFLD), has emerged as the most prevalent cause of chronic liver disease worldwide.
Olfa Khalifa, Abdelilah Arredouani
doaj   +2 more sources

Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. [PDF]

PLoS ONE, 2010
GLP-1 has a variety of anti-diabetic effects. However, native GLP-1 is not suitable for therapy of diabetes due to its short half-life (t1/2168 h. Intraperitoneal glucose tolerance test (IPGTT) in mice showed that GLP-1/hIgG2 significantly decreased ...
Qinghua Wang, Kui Chen, Rui Liu, Fang Zhao, Sandeep Gupta, Nina Zhang, Gerald J Prud'homme   +6 more
doaj   +4 more sources

Beyond GLP‐1 [PDF]

Journal of Diabetes
Zachary Bloomgarden
doaj   +2 more sources

Glucagon-like peptide 1 (GLP-1)

Molecular Metabolism, 2019
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying ...
Jens J Holst Dmsci, Michael A Nauck
exaly   +3 more sources

An Update on GLP‐1 Receptor Agonists [PDF]

Journal of Diabetes
Zachary Bloomgarden
doaj   +2 more sources

Age and Gender Effects on Genotoxicity in Diesel Exhaust Particles Exposed C57BL/6 Mice

Biomolecules, 2021
There is growing evidence that the accumulation of DNA damage induced by fine particulate matter (PM2.5) exposure is an underlying mechanism of pulmonary disease onset and progression.
Joong Won Lee, Jin Sik Kim, Hee Jae Lee, Ji-Hye Jang, Ja-Hyun Kim, Woo Jong Sim, Yong-beom Lim, Ji-Won Jung, Hyun Joung Lim   +8 more
doaj   +1 more source

Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. [PDF]

PLoS ONE, 2013
Glucagon-like-peptide-1 (GLP-1) is a gut- and neuro-peptide with an important role in the regulation of food intake and glucose metabolism. Interestingly, GLP-1 receptors (GLP-1R) are expressed in key mesolimbic reward areas (including the ventral ...
Rozita H Shirazi, Suzanne L Dickson, Karolina P Skibicka   +2 more
doaj   +1 more source

Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

Pharmaceuticals, 2022
Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes.
Lei Sun, Zhi-Ming Zheng, Chang-Sheng Shao, Zhi-Yong Zhang, Ming-Wei Li, Li Wang, Han Wang, Gen-Hai Zhao, Peng Wang   +8 more
doaj   +1 more source

Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets [PDF]

, 2020
Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake.
Davis, Dawn, de Souza, Arnaldo Henrique, Kibbe, Carly R., Linnemann, Amelia K., Merrins, Matthew J., Saghafi, Samuel T., Tang, Jiayin, Yadev, Amanjot Kaur   +7 more
core   +1 more source

Brain Endothelial Cells Regulate Glucagon-Like Peptide 1 Entry Into the Brain via a Receptor-Mediated Process

Frontiers in Physiology, 2020
Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects.
Zhuo Fu, Liying Gong, Liying Gong, Jia Liu, Jing Wu, Jing Wu, Eugene J. Barrett, Kevin W. Aylor, Zhenqi Liu   +8 more
doaj   +1 more source