Results 1 to 10 of about 85,699 (115)

Glucagon-like peptide 1 (GLP-1)

Molecular Metabolism, 2019
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying ...
Peter R. Flatt, Frank Reimann, Thue W Schwartz   +2 more
exaly   +3 more sources

Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity. [PDF]

Life (Basel)
Genetic variation may contribute to interindividual differences in the efficacy and tolerability of glucagon-like peptide-1 receptor agonists (GLP-1RAs), although the available evidence remains limited.
Fernandes MT, Dias JC, Espírito-Santo M, Estêvão MD, De Sousa-Coelho AL.   +4 more
europepmc   +2 more sources

Beyond GLP-1. [PDF]

J Diabetes
Bloomgarden Z.
europepmc   +2 more sources

GLP-1 Medicines in Perspective: Approaches to Optimize Outcome. [PDF]

J Diabetes
Bloomgarden Z.
europepmc   +2 more sources

Age and Gender Effects on Genotoxicity in Diesel Exhaust Particles Exposed C57BL/6 Mice

Biomolecules, 2021
There is growing evidence that the accumulation of DNA damage induced by fine particulate matter (PM2.5) exposure is an underlying mechanism of pulmonary disease onset and progression.
Joong Won Lee, Jin Sik Kim, Hee Jae Lee, Ji-Hye Jang, Ja-Hyun Kim, Woo Jong Sim, Yong-beom Lim, Ji-Won Jung, Hyun Joung Lim   +8 more
doaj   +1 more source

Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. [PDF]

PLoS ONE, 2010
GLP-1 has a variety of anti-diabetic effects. However, native GLP-1 is not suitable for therapy of diabetes due to its short half-life (t1/2168 h. Intraperitoneal glucose tolerance test (IPGTT) in mice showed that GLP-1/hIgG2 significantly decreased ...
Qinghua Wang, Kui Chen, Rui Liu, Fang Zhao, Sandeep Gupta, Nina Zhang, Gerald J Prud'homme   +6 more
doaj   +1 more source

Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. [PDF]

PLoS ONE, 2013
Glucagon-like-peptide-1 (GLP-1) is a gut- and neuro-peptide with an important role in the regulation of food intake and glucose metabolism. Interestingly, GLP-1 receptors (GLP-1R) are expressed in key mesolimbic reward areas (including the ventral ...
Rozita H Shirazi, Suzanne L Dickson, Karolina P Skibicka   +2 more
doaj   +1 more source

Engineered probiotics Clostridium butyricum‐pMTL007‐GLP‐1 improves blood pressure via producing GLP‐1 and modulating gut microbiota in spontaneous hypertension rat models

Microbial Biotechnology, 2023
Hypertension is a significant risk factor of cardiovascular diseases (CVDs) with high prevalence worldwide, the current treatment has multiple adverse effects and requires continuous administration.
Xin‐liang Wang, Wen‐jie Chen, Rui Jin, Xuan Xu, Jing Wei, Hong Huang, Yan‐hua Tang, Chang‐wei Zou, Ting‐tao Chen   +8 more
doaj   +1 more source

Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

Pharmaceuticals, 2022
Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes.
Lei Sun, Zhi-Ming Zheng, Chang-Sheng Shao, Zhi-Yong Zhang, Ming-Wei Li, Li Wang, Han Wang, Gen-Hai Zhao, Peng Wang   +8 more
doaj   +1 more source

Brain Endothelial Cells Regulate Glucagon-Like Peptide 1 Entry Into the Brain via a Receptor-Mediated Process

Frontiers in Physiology, 2020
Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects.
Zhuo Fu, Liying Gong, Liying Gong, Jia Liu, Jing Wu, Jing Wu, Eugene J. Barrett, Kevin W. Aylor, Zhenqi Liu   +8 more
doaj   +1 more source