Results 41 to 50 of about 1,660 (124)

Probing the Binding Site of Bile Acids in TGR5

, 2013
TGR5 is a G-protein-coupled receptor (GPCR) mediating cellular responses to bile acids (BAs). Although some efforts have been devoted to generate homology models of TGR5 and draw structure-activity relationships of BAs, none of these studies has hitherto
Giacche, Nicola, Gioiello, Antimo, Schoonjans, Kristina, Pruzanski, Mark, Pols, Thijs W. H., De Franco, Francesca, Pellicciari, Roberto, Thomas, Charles, Auwerx, Johan, Macchiarulo, Antonio, Nuti, Roberto, Ferrari, Cristina   +11 more
core   +2 more sources

The TGR5 receptor mediates bile acid-induced itch and analgesia [PDF]

, 2013
Fulltext embargoed for: 6 months post date of publicationPatients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown.
Nassini, R, Poole, DP, Guerrero-Alba, R, Cottrell, GS, Bunnett, NW, Cevikbas, F, Corvera, CU, Alemi, F, Lyo, V, Steinhoff, M, Geppetti, P, Valdez-Morales, E, Kwon, E, Cattaruzza, F, Lieu, TM, Materazzi, S, Schoonjans, K, Vanner, SJ   +17 more
core   +2 more sources

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation

Journal of Lipid Research, 2018
Simultaneous activation of bile acid receptors farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) by INT-767 significantly reduces atherosclerotic formation. In this study, we investigated the effect of simultaneous inactivation
Shinobu Miyazaki-Anzai, Masashi Masuda, Shohei Kohno, Moshe Levi, Yuji Shiozaki, Audrey L. Keenan, Makoto Miyazaki   +6 more
doaj   +1 more source

Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers

Antioxidants, 2022
Cholestatic chronic liver disease is characterized by developing sarcopenia and elevated serum levels of bile acids. Sarcopenia is a skeletal muscle disorder with the hallmarks of muscle weakness, muscle mass loss, and muscle strength decline.
Johanna Abrigo, Hugo Olguín, Danae Gutierrez, Franco Tacchi, Marco Arrese, Daniel Cabrera, Mayalen Valero-Breton, Alvaro A. Elorza, Felipe Simon, Claudio Cabello-Verrugio   +9 more
doaj   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

Frontiers in Pharmacology, 2017
Worldwide, metabolic diseases such as obesity and type 2 diabetes have reached epidemic proportions. A major regulator of metabolic processes that gained interest in recent years is the bile acid receptor TGR5 (Takeda G protein-coupled receptor 5).
Angela Ladurner, Martin Zehl, Martin Zehl, Martin Zehl, Ulrike Grienke, Christoph Hofstadler, Nadina Faur, Fátima C. Pereira, David Berry, Verena M. Dirsch, Judith M. Rollinger   +10 more
doaj   +1 more source

TGR5 Agonists in Development. Small Molecule Approaches

, 2012
TGR5 is a lipid G-protein-coupled receptor (GPCR) endogenously activated by bile acids (BAs). The scientific interest in TGR5 is continuously rising since it has been implicated in mediating the so termed non genomic actions of BAs, which include ...
GIOIELLO, ANTIMO, PELLICCIARI, Roberto, MACCHIARULO, Antonio   +2 more
core   +1 more source

The bile acid receptor TGR5 and cholestasis [PDF]

, 2022
During liver injury and cholestasis, the mechanisms allowing the organ to protect itself with the aim of maintaining biliary homeostasis are not completely understood.
Valeska Bidault-Jourdainne, Isabelle Garcin, Isabelle Doignon, Thierry Tordjmann, Grégory Merlen   +4 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source