Results 31 to 40 of about 1,660 (124)

Bile Acids Reduced the Lipid Deposition in Fatty Degenerated Hepatocytes of Pearl Gentian Grouper (Epinephelus fuscoguttatus♂ × Epinephelus lanceolatus♀) in vitro

Frontiers in Marine Science, 2022
Little is known about the association of bile acids (BAs) with lipid deposition and lipid metabolism of fish in vitro. In the present study, we established the model of fatty-degenerated hepatocytes in pearl gentian grouper (Epinephelus fuscoguttatus ...
Jia Xu, Xinzhou Yao, Xiaoyue Li, Shiwei Xie, Shiwei Xie, Shiwei Xie, Shiwei Xie, Shuyan Chi, Shuyan Chi, Shuyan Chi, Shuang Zhang, Shuang Zhang, Shuang Zhang, Junming Cao, Junming Cao, Junming Cao, Beiping Tan, Beiping Tan, Beiping Tan   +18 more
doaj   +1 more source

Bile acid receptors and renal regulation of water homeostasis

Frontiers in Physiology, 2023
The kidney is the key organ responsible for maintaining the body’s water and electrolyte homeostasis. About 99% of the primary urine filtered from the Bowman’s capsule is reabsorbed along various renal tubules every day, with only 1–2 L of urine excreted.
Yanlin Guo, Yanlin Guo, Taotao Luo, Guixiang Xie, Xiaoyan Zhang, Xiaoyan Zhang   +5 more
doaj   +1 more source

Hepatoprotective impact of the bile acid receptor TGR5

, 2020
International audienceDuring liver repair after injury, bile secretion has to be tightly modulated in order to preserve liver parenchyma from bile acid (BA)-induced injury.
Mathilde Glenisson, Isabelle Garcin, Rainteau, Dominique, Bidault-Jourdainne, Valeska, Kahale, Nicolas, Dominique Rainteau, Grégory Merlen, Tordjmann, Thierry, Ursic-Bedoya, José, José Ursic‐Bedoya, Valeska Bidault‐Jourdainne, Lydie Humbert, Bidault‐jourdainne, Valeska, Nicolas Kahale, Isabelle Doignon, Ursic‐bedoya, José, Doignon, Isabelle, Humbert, Lydie, Thierry Tordjmann, Merlen, Grégory, Garcin, Isabelle, Glenisson, Mathilde   +21 more
core   +1 more source

Hesperetin and Naringenin promote glucagon-like peptide-1 secretion from L-cell through activation of TGR5 and alleviated type 2 diabetes

Frontiers in Pharmacology
PurposeGlucagon-like peptide-1 (GLP-1) secretagogues offer therapeutic potential for type 2 diabetes. Bioactive compounds in citrus were supposed to be effective in treating diabetes, while exact compounds activating enteroendocrine L-cell pathways ...
Chen-Yang Zhang, Chen-Yang Zhang, Zi-Lu Wang, Zi-Lu Wang, Ze-Ju Jiang, Ze-Ju Jiang, Hanna Kim, Hanna Kim, Chang Liu, Hao Wang, Hao Wang   +10 more
doaj   +1 more source

The role of TGR5 as an onco-immunological biomarker in tumor staging and prognosis by encompassing the tumor microenvironment

Frontiers in Oncology, 2022
The relationship between G protein–coupled bile acid receptor 1 (TGR5, GPBAR1) and, specifically, cancer has been studied in in vivo and in vitro experiments, but there is still a lack of pan-cancer analysis to understand the prognostic significance and ...
Zhiyuan Guan, Liying Luo, Shengfu Liu, Zhiqiang Guan, Qinggang Zhang, Zhong Wu, Kun Tao   +6 more
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Activation of the TGR5/cAMP/PKA/CREB axis in cholangiocytes mediates epithelial-mesenchymal transition and fibrosis in hepatolithiasis

Biology Direct
Background The molecular mechanisms linking bile acid signaling to biliary fibrosis in hepatolithiasis are unclear. We investigated the role of the bile acid receptor TGR5 in driving fibrotic progression. Methods We employed an integrated strategy.
Dan Tang, Jiali Yang, Xinhao Shi, Xuanyu Gu, Lijin Zhao   +4 more
doaj   +1 more source

Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes

Molecules
Agonists of the G protein-coupled receptor TGR5 have long been sought-after for their metabolic benefits. Intestinal TGR5 activation induces secretion of the antidiabetic hormone GLP-1, which can systemically improve diabetes phenotypes in multiple ...
Rachana S. Bhimanwar, Zachary Detwiler, Jinge G. Zhu, Samuel T. Saghafi, Carolyn A. Winder, Dawn Belt Davis, Amit Mittal, Vikas Sharma, David A. Harris, Snehal N. Chaudhari   +9 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source