Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM [PDF]
Scientific ReportsMany physiological processes are dependent on G protein-coupled receptors (GPCRs), the biggest family of human membrane proteins and a significant class of therapeutic targets.
Jérôme Castel +11 more
exaly +3 more sources
Cells, 2022 Background & Aims: ACE2, a carboxypeptidase that generates Ang-(1-7) from Ang II, is highly expressed in the lung, small intestine and colon. GPBAR1, is a G protein bile acid receptor that promotes the release of the insulinotropic factor glucagon-like ...
Cristina Di Giorgio +2 more
exaly +3 more sources
Gpbar1-mediated SIRT1-PGC-1α axis maintains mitochondrial homeostasis and mitigates renal injury in obstructive jaundice [PDF]
Scientific ReportsObstructive jaundice (OJ)-induced kidney injury has a high mortality rate, severely affecting patient prognosis. Gpbar1, a bile acid receptor, plays a key role in maintaining tissue homeostasis in organs such as the liver and pancreas during OJ. However,
Mingchen Li +7 more
doaj +2 more sources
Multi-omics profiling identifies M1 macrophage polarization-associated biomarkers in hepatitis B virus-related acute-on-chronic liver failure [PDF]
Frontiers in MicrobiologyBackground and aimsM1 macrophage polarization is essential for the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).
Chengxi Sun +9 more
doaj +2 more sources
A bile acid–GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis [PDF]
Gut MicrobesIntestinal fibrosis is a severe complication of Crohn's disease for which therapy remains suboptimal. Probiotics are widely used in the treatment of intestinal inflammation, but all major guidelines do not recommend in favor of their use, with the ...
Michele Biagioli +14 more
doaj +2 more sources
Pharmacological ResearchInflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and persistent inflammation.
Martina Bordoni, Eleonora Distrutti
exaly +3 more sources
Roles of Bile Acid-Activated Receptors in Monocytes-Macrophages and Dendritic Cells [PDF]
CellsBile acids (BAs), essential for lipid metabolism and fat-soluble vitamin absorption, also act as signaling molecules that regulate immune homeostasis.
Huilin Jia +3 more
doaj +2 more sources
Mechanistic study of deoxycholic acid in colorectal cancer based on network toxicology and machine learning approaches [PDF]
BMC Pharmacology and ToxicologyObjective This study aims to explore the mechanistic role of deoxycholic acid (DCA) in colorectal cancer (CRC) through the integration of network toxicology and machine learning approaches.
Yulai Yin +5 more
doaj +2 more sources
Phocaeicola dorei YGMCC0564 attenuates HFD-induced glycolipid metabolic disorders in association with remodeling of the gut microbiota and bile acid profiles [PDF]
Frontiers in MicrobiologyBackgroundGlycolipid Metabolic Disorders (GLMD) are characterized by imbalances in glucose and lipid homeostasis, often presenting with severe clinical symptoms.
Zhili He +7 more
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Epigallocatechin-3-gallate supplementation regulates glucose redistribution through its potential endogenous receptor in grass carp (Ctenopharyngodon idella) [PDF]
Animal NutritionExploring exogenous additives to enhance non-protein energy ingredient utilization in fish is highly anticipated. Epigallocatechin-3-gallate (EGCG) is a prominent polyphenol found in green tea.
Fan Chen +8 more
doaj +2 more sources