Results 1 to 10 of about 22,496 (211)
RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction. [PDF]
PLoS ONE, 2017 Retinoic acid receptor-related orphan nuclear receptor γt (RORγt) is a transcriptional factor responsible for IL-17-producing T-cell differentiation. Although it was demonstrated that RORγt plays essential roles in the onset of autoimmune myocarditis ...
Daichi Enomoto +7 more
doaj +2 more sources
Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases
Journal of Pharmaceutical Analysis, 2023 As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt) that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a critical role in the progression of several inflammatory and ...
Jiuping Zeng +19 more
doaj +2 more sources
Effects of RORγt overexpression on the murine central nervous system [PDF]
Neuropsychopharmacology Reports, 2021 Objective T helper 17 (Th17) cells are a subset of CD4+ T cells that produce interleukin (IL)‐17A. Recent studies showed that an increase in circulating IL‐17A causes cognitive dysfunction, although it is unknown how increased systemic IL‐17A affects ...
Tetsuya Sasaki +3 more
doaj +2 more sources
Journal of Experimental & Clinical Cancer Research, 2022 Background The overall response rate to checkpoint blockade remains unsatisfactory, partially due to the immune-suppressive tumor microenvironment. A retinoic acid-related orphan receptor γt (RORγt) agonist (LYC-55716) is currently used in clinical ...
Li Xia +11 more
doaj +2 more sources
RORγt and RORα signature genes in human Th17 cells. [PDF]
PLoS ONE, 2017 RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation.
Glenda Castro +15 more
doaj +2 more sources
Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro [PDF]
Frontiers in Immunology, 2021 IntroductionCD4+ T cells with regulatory function co-expressing Foxp3 and RORγt are linked to the development of oral tolerance towards innocuous food antigens in mice.
Mónica Martínez-Blanco +5 more
doaj +2 more sources
RORγt phosphorylation protects against T cell-mediated inflammation [PDF]
Cell Reports, 2022 SUMMARY RAR-related orphan receptor-γ (RORγt) is an essential transcription factor for thymic T cell development, secondary lymphoid tissue organogenesis, and peripheral immune cell differentiation.
Shengyun Ma +10 more
semanticscholar +2 more sources
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens [PDF]
Nature CommunicationsOral tolerance represents a hallmark of intestinal mucosal immunity to prevent inflammatory responses to harmless natural antigens, such as dietary components or commensal organisms.
Jie Zhao +10 more
doaj +2 more sources
Digoxin, an Overlooked Agonist of RORγ/RORγT [PDF]
Frontiers in Pharmacology, 2019 Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects.
Kaja Karaś +7 more
doaj +2 more sources
RORγt<sup>+</sup> dendritic cells are a distinct lymphoid-derived lineage. [PDF]
Sci ImmunolHow tolerogenic dendritic cell (DC) lineages are established to prevent inappropriate immune responses to commensals and food antigens remains unclear. We identify RORγt+ DCs as a distinct lymphoid-derived lineage to safeguard intestinal tolerance. Using
Rodrigues PF +7 more
europepmc +2 more sources