Results 11 to 20 of about 22,496 (211)

In vitro generation of RORγt+ regulatory T cells reveals enhanced immunosuppressive function and OXPHOS-dependent metabolism [PDF]

Frontiers in Immunology
BackgroundRORγt+ regulatory T cells (Treg) play a crucial role in immune regulation, particularly in the gut. However, most current knowledge about this subset derives from in vivo studies, as in vitro investigation has been limited by the lack of ...
Marcella Cipelli, Eloísa Martins da Silva, Lais Cavalieri Paredes, Mariana Abrantes do Amaral, Barbara Nunes Padovani, Luísa Menezes-Silva, Vinicius Andrade-Oliveira, Niels Olsen Saraiva Camara, Niels Olsen Saraiva Camara   +8 more
doaj   +2 more sources

Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection

Cell Reports
Summary: T helper (Th)17 cells mediate both protective anti-bacterial immune responses and autoimmune pathogenesis, but the distinct pathways regulating these Th17 responses remain unclear.
Xiancai Zhong, Hongmin Wu, Wencan Zhang, Yun Shi, Yousang Gwack, Hai-hui Xue, Zuoming Sun   +6 more
doaj   +2 more sources

Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy

, 2023
The master transcription factor receptor retinoic acid receptor-related orphan receptor γt (RORγt) regulates the differentiation of T-helper 17 (Th17) cells and the production of interleukin-17 (IL-17).
Yonghui Wang (287491), Yunpeng Zhao (2225479), Di Zhu (1450108), Meiqi Song (9652128), Meiling Zhao (686647), Qiong Xie (709001), Ruomeng Qiu (12255136), Ji-an Chen (519664), Mingcheng Yu (7115498), Yafei Huang (539526), Nannan Sun (1360230), Haojie Wang (3072141), Li Xia (82871), Yan Li (23143), Huimin Guo (350020), Lixue Lu (17417426)   +15 more
core   +7 more sources

Teucrium polium Extract Attenuates Inflammation in Asthma by Reducing RORγt Transcription and Increasing IL-10 Secretion in an Ovalbumin-induced Murine Asthma Model [PDF]

Iranian Journal of Immunology, 2023
Background: One of the inflammatory diseases of the respiratory system is asthma. Teucrium polium (TP) has anti-inflammatory and anti-allergic properties and its anti-asthmatic effects have not been investigated yet.
Shole Daneshvar-ghahfarokhi, Amir Rahnama, Vahid Mohammadi-Shahrokhi   +2 more
doaj   +1 more source

Mechanism of zingerone alleviating colitis induced by dextran sodium sulfate in mice

陆军军医大学学报, 2023
Objective To investigate the efficacy of zingerone (Zin) on dextran sodium sulfate (DSS)-induced colitis in mice and its potential immunomodulatory mechanism. Methods SPF C57BL/6 male mice aged 6 to 8 weeks were divided into control group (Water), model
LI Jing, LUO Ya, ZHANG Shengwei, WANG Jing, HU Changjiang   +4 more
doaj   +1 more source

Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling

Pharmaceutical Biology, 2021
Context Alantolactone, the bioactive component in Inula helenium L. (Asteraceae), exhibits multiple biological effects. Objective We aimed to determine the anti-inflammatory effect of alantolactone in a collagen-induced arthritis (CIA) mouse model and ...
Hsiang-Lai Chen, Shih Chao Lin, Shiming Li, Kuo-Tung Tang, Chi-Chien Lin   +4 more
doaj   +1 more source

Bile acid dysmetabolism in inflammatory bowel diseases

Alʹmanah Kliničeskoj Mediciny, 2023
Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in ...
Daria A. Kuznetsova, Sergey V. Lapin, Irina V. Gubonina   +2 more
doaj   +1 more source

INFLUENCE OF HOMEOSTATIC CYTOKINES – IL-7 AND IL-15 ON T-REGULATORY CELLS IN VITRO

Медицинская иммунология, 2021
Cytokines IL-7 and IL-15 are the most important humoral factors providing T-conventional cell pool reconstitution during homeostatic proliferation caused by lymphopenia.
D. V. Shevyrev, V. A. Kozlov
doaj   +1 more source

Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice

Journal of Neuroinflammation, 2021
Background Tuberous sclerosis complex 1 (Tsc1) is known to regulate the development and function of various cell types, and RORγt is a critical transcription factor in the immune system.
Yafei Deng, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Shuju Zhang, Baige Yao, Shuhui Li, Yuan Gao, Xiaohui Li, Liping Li, Youcai Deng   +12 more
doaj   +1 more source

A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

Nature, 2022
The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment 1 , 2 .
Ranit Kedmi, T. Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yu-Han Hao, S. Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, C. Lareau, Ansuman T. Satpathy, Mark S. Anderson, T. Laufer, I. Aifantis, Juliet M. Bartleson, P. Allen, H. Paidassi, J. Gardner, Marlon Stoeckius, D. Littman   +22 more
semanticscholar   +1 more source