Results 21 to 30 of about 22,496 (211)

A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3

Biomolecules, 2020
Among diverse helper T-cell subsets, Th17 cells appear to be pathogenic in diverse autoimmune diseases, and thus, targeting Th17 cells could be beneficial for the treatment of the diseases in humans.
Young-Jun Park, Minkyoung Cho, Garam Choi, Hyeongjin Na, Yeonseok Chung   +4 more
doaj   +1 more source

The emerging family of RORγt+ antigen-presenting cells

Nature reviews. Immunology, 2023
Recent studies have revealed a family of antigen-presenting cells (APCs) marked by the transcription factor RORγt that fundamentally shape immunity, inflammation and tolerance.
J. Abramson, J. Dobeš, Mengze Lyu, Gregory F. Sonnenberg   +3 more
semanticscholar   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism

Cell Reports, 2023
SUMMARY Micronutrient deficiency is a major cause of disease throughout the world. Yet, how perturbations influence the immune-microbiome interface remains poorly understood.
Lucille C. Rankin, Katherine A Kaiser, Kenia de los Santos-Alexis, Heekuk Park, Uhlemann Anne-Catrin, D. Gray, Nicholas Arpaia   +6 more
semanticscholar   +1 more source

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis

Nature Communications, 2023
Th17 cells produce a range of characteristic Th17 type cytokines and express transcription factors governed by epigenetic regulation to engage the Th17 programme. Here the authors implicate the RNA 5- methylcytosine (m^5C) methyltransferase Nsun2 in Th17
Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, W. Li, Pengchun Yang, Yun-Gui Yang   +14 more
semanticscholar   +1 more source

Alterations of milk oligosaccharides in mothers with gestational diabetes mellitus impede colonization of beneficial bacteria and development of RORγt+ Treg cell-mediated immune tolerance in neonates

Gut microbes, 2023
Gestational diabetes mellitus (GDM) is an increasing public health concern that significantly increases the risk of early childhood allergic diseases.
Xin-Ke Li, Xixi Ning, Binqi Rui, Yushuang Wang, Zengjie Lei, Da Yu, Fei-Tong Liu, Yan-Jie Deng, Jie-Li Yuan, Wen-Zhe Li, Jingyu Yan, Ming Li   +11 more
semanticscholar   +1 more source

A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance The immune system’s role in maintaining self-tolerance and preventing autoimmunity is critical. Recent mouse studies have identified dendritic cell (DC) populations that preserve immune tolerance to intestinal microflora in the gut.
Alina Ulezko Antonova, S. Lonardi, Matilde Monti, Francesco Missale, Changxu Fan, Matthew L. Coates, M. Bugatti, N. Jaeger, Patrick Fernandes Rodrigues, S. Brioschi, Tihana Trsan, J. Fachi, Khai M. Nguyen, Ryan M. Nunley, D. Moratto, S. Zini, Lingjia Kong, Jacques Deguine, M. Peeples, Ramnik J Xavier, M. Clatworthy, Ting Wang, M. Cella, W. Vermi, Marco Colonna   +24 more
semanticscholar   +1 more source

TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

Microbiome, 2022
Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions as a sensor mediating the
Yaojiang Liu, Min Yang, Li Tang, Fengchao Wang, Shengjie Huang, Shuang Liu, Yuan-Yuan Lei, Sumin Wang, Zhuo Xie, Wei Wang, Xiaoyan Zhao, Bo Tang, Shi-Ming Yang   +12 more
semanticscholar   +1 more source

Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification

Experimental and Molecular Medicine, 2023
Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEVs) are known to exert immunosuppressive functions. This study showed that MSC-sEVs specifically convert T helper 17 (Th17) cells into IL-17 low-producer (ex-Th17) cells by degrading
Sunhoe Lee, Sunyoung Jung, Hyun Je Kim, Sueon Kim, J. Moon, Hyunwoo Chung, Seong-Jun Kang, Chung-Gyu Park   +7 more
semanticscholar   +1 more source

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

Nature Communications, 2021
T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt.
Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu   +14 more
doaj   +1 more source