Results 31 to 40 of about 22,496 (211)

RORγt inhibition ameliorates IL-23 driven experimental Psoriatic Arthritis by predominantly modulating γδ-T cells.

Rheumatology, 2023
OBJECTIVE Divergent therapeutic outcomes on different disease domains have been noted with interleukin (IL)-23 and IL-17A-blockade in psoriatic arthritis (PsA).
C. Mortier, Eric Gracey, J. Coudenys, Teddy Manuello, T. Decruy, Margaux Maelegheer, Flore Stappers, E. Gilis, D. Gaublomme, L. Van Hoorebeke, Sophie Van Welden, C. Ambler, M. Hegen, P. Symanowicz, Stefan J Steyn, G. Berstein, D. Elewaut, K. Venken   +17 more
semanticscholar   +1 more source

The Emerging Landscape of RORγt Biology [PDF]

, 2014
The transcription factor retinoid-related orphan receptor gamma t (RORγt) has emerged as an exciting target for inflammatory diseases. Xiao et al. (2014) show that a new class of RORγt antagonists can inhibit the inflammatory function of T helper 17 ...
Cua, Daniel J., Lee, Jacob S.
core   +1 more source

Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells

Frontiers in Immunology, 2020
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota.
Hind Hussein, Sébastien Denanglaire, Frédéric Van Gool, Frédéric Van Gool, Abdulkader Azouz, Yousra Ajouaou, Hana El-Khatib, Guillaume Oldenhove, Oberdan Leo, Fabienne Andris   +9 more
doaj   +1 more source

Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium. [PDF]

PLoS ONE, 2016
Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial disease in humans. The role of Th17 immunity in the pathogenesis of intracellular bacteria, such as MAC, is not currently understood.
Masashi Matsuyama, Yukio Ishii, Hirofumi Sakurai, Satoshi Ano, Yuko Morishima, Keigyou Yoh, Satoru Takahashi, Kenji Ogawa, Nobuyuki Hizawa   +8 more
doaj   +1 more source

Immunoblotting for RORγt in thymic cells from wild-type and RORγt^-/- mice.

, 2021
Thymic cells were isolated from thymuses harvested from wild-type (WT) and RORγt-/- (KO) mice. Cytoplasmic and nuclear extracts were prepared by cellular fractionation, resolved by SDS-PAGE, and analyzed by immunoblotting with an antibody directed ...
Bhawna Yadav (172612), Maria Pokrovskii (11362107), Jun R. Huh (2004790), Stuart M. Levitz (10326566), Chrono K. Lee (11362104), Charles A. Specht (10326563), Dan R. Littman (82)   +6 more
core   +1 more source

Lung eosinophils elicited during allergic and acute aspergillosis express RORγt and IL-23R but do not require IL-23 for IL-17 production.

PLoS Pathogens, 2021
Exposure to the mold, Aspergillus, is ubiquitous and generally has no adverse consequences in immunocompetent persons. However, invasive and allergic aspergillosis can develop in immunocompromised and atopic individuals, respectively.
Bhawna Yadav, Charles A Specht, Chrono K Lee, Maria Pokrovskii, Jun R Huh, Dan R Littman, Stuart M Levitz   +6 more
doaj   +1 more source

Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1α/RORγt pathway

Redox Report, 2023
Background Acquired aplastic anemia (AA) is a life-threatening disease associated with an imbalance in Th17/Treg cells. Regulating this balance may be an effective treatment approach for AA.
Zeng-Hui Liu, Lixuan Chen, Defang Xiong, Yu Zhan, Jiduo Liu, Ling Ouyang, Wancheng Chen, Zi-Yuan Lu, Tian-Qi Gao, Xiaozhen Li, Yan-Qun Zhou, Xuekui Gu, Yang Xiao   +12 more
semanticscholar   +1 more source

Identity, regulation and in vivo function of gut NKp46(+)RORγt(+) and NKp46(+)RORγt(-) lymphoid cells. [PDF]

, 2011
The gut is a major barrier against microbes and encloses various innate lymphoid cells (ILCs), including two subsets expressing the natural cytotoxicity receptor NKp46.
Aubry, Camille, Fenis, Aurore, Eric Vivier, Renauld, Jean-Christophe, Reynders, Ana, Marc Dalod, Renauld, Jean Christophe, Nadia Yessaad, Vu Manh, Thien-Phong, Pascale Cossart, Olivier Dussurget, Dalod, Marc, Lecuit, Marc, Thien-Phong Vu Manh, Elena Tomasello, Georgios Nikitas, Escalière, Bertrand, Tomasello, Elena, Nikitas, Georgios, Bertrand Escalière, Yessaad, Nadia, Cossart, Pascale, Marc Lecuit, Vivier, Eric, Camille Aubry, Jean Christophe Renauld, Ana Reynders, Dussurget, Olivier, Aurore Fenis   +28 more
core   +1 more source

RNA binding protein DDX5 restricts RORγt+ Treg suppressor function to promote intestine inflammation

Science Advances, 2023
Retinoid-related orphan receptor (RAR) gamma (RORγt)–expressing regulatory T cells (RORγt+ Tregs) play pivotal roles in preventing T cell hyperactivation and maintaining tissue homeostasis, in part by secreting the anti-inflammation cytokine interleukin ...
Shengyun Ma, Qiyuan Yang, Nicholas Chen, Anna Zheng, Nazia Abbasi, Gaowei Wang, Parth R Patel, Benjamin S. Cho, Brian A. Yee, Lunfeng Zhang, Hiutung Chu, Sylvia M. Evans, Gene W. Yeo, Ye Zheng, W. Huang   +14 more
semanticscholar   +1 more source

RORγt protein modifications and IL-17-mediated inflammation

Trends in immunology, 2021
RORγt, the master transcription factor for cytokine IL-17, is expressed explicitly in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans.
Ritesh Kumar, Arianne L. Theiss, K. Venuprasad   +2 more
semanticscholar   +1 more source