Results 51 to 60 of about 22,496 (211)

Identification of an allosteric binding site for RORγt inhibition [PDF]

, 2015
RORγt is critical for the differentiation and proliferation of Th17 cells associated with several chronic autoimmune diseases. We report the discovery of a novel allosteric binding site on the nuclear receptor RORγt.
Kutilek, V, Stelt, van der, M., Barr, K, Soisson, S.M., Kornienko, M., Parthasarathy, G, Sharma, S., Oubrie, A., Piesvaux, J., Scheepstra, M., van Eenennaam, H, Scheepstra, M Marcel, Elsen, N., Leysen, SFR Seppe, Elsen, N, Soisson, SM, Ottmann, C Christian, Correll, C.C., Miller, JR, Zhang, H., Eenennaam, H. van, Kutilek, V., Stelt, M. van der, van Almen, G., van Eenennaam, H., Parthasarathy, G., Piesvaux, J, Almen, G.C. van, Nagpal, S, Brunsveld, L Luc, Kornienko, M, Leysen, S., Wiley, K, Wiley, K., Brunsveld, L., Ottmann, C., Oubrie, A, Miller, J.R., Correll, CC, Trotter, B.W., Nagpal, S., Barr, K., Almen, GC Geert van, Zhang, H, Trotter, BW, Sharma, S, Stelt, M van der, Brunsveld, L.; id_orcid   +47 more
core   +2 more sources

RORγt expression in mature TH17 cells safeguards their lineage specification by inhibiting conversion to TH2 cells

Science Advances, 2022
RORγt is the lineage-specific transcription factor for T helper 17 (TH17) cells and an attractive drug target for treating TH17-associated diseases. Although the critical role of RORγt in early TH17 cell differentiation has been well recognized, its ...
Xinxin Chi, W. Jin, Xiaohong Zhao, T. Xie, Jing Shao, Xue Bai, Yu Jiang, Xiaohu Wang, C. Dong   +8 more
semanticscholar   +1 more source

IL-22-producing RORγt-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis.

PLoS ONE, 2013
Retinoid-related orphan receptor (ROR) γt is known to be related to the development and function of various immunological compartments in the liver, such as Th17 cells, natural killer T (NKT) cells, and innate lymphoid cells (ILCs).
Atsuhiro Matsumoto, Takanori Kanai, Yohei Mikami, Po-Sung Chu, Nobuhiro Nakamoto, Hirotoshi Ebinuma, Hidetsugu Saito, Toshiro Sato, Hideo Yagita, Toshifumi Hibi   +9 more
doaj   +1 more source

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens

Cell
The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally-derived RORγt+Tregs (pTregs), which prevent food intolerance and inflammatory bowel disease.
P. F. Rodrigues, Shi-Tong Wu, Tihana Trsan, Santosh K. Panda, J. Fachi, Yi-Zhou Liu, Si-Ling Du, Sarah de Oliveira, A. U. Antonova, Darya Khantakova, R. Sudan, Pritesh Desai, Michael S. Diamond, S. Gilfillan, Stephen K. Anderson, M. Cella, M. Colonna   +16 more
semanticscholar   +1 more source

RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells

Proceedings of the National Academy of Sciences of the United States of America
Significance Antigen-presenting cells (APCs) orchestrate T cell immunity. Retinoic acid receptor-related orphan receptor-γt (RORγt)-expressing APCs are heterogenous regulators of T cell tolerance but their subtypes and lineage relationships are ill ...
Hamsa Narasimhan, M. Richter, Ramin Shakiba, Nikos E. Papaioannou, Christina Stehle, Kaushikk Ravi Rengarajan, I. Ulmert, Arek Kendirli, Clara de la Rosa, Pin-Yu Kuo, Abigail Altman, Philipp Münch, Saba Mahboubi, Vanessa Küntzel, Amina Sayed, Eva-Lena Stange, Jonas Pes, Alina Ulezko Antonova, Carlos-Filipe Pereira, Ludger Klein, Diana Dudziak, Marco Colonna, N. Torow, M. Hornef, B. E. Clausen, Martin Kerschensteiner, K. Lahl, C. Romagnani, Maria Colomé-Tatché, B. Schraml   +29 more
semanticscholar   +1 more source

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist

, 2019
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells.
Robert Skene (1417273), Takayuki Sato (253061), Noriko Uchiyama (1920913), Gyorgy Snell (1399558), Yoshi Nara (4962871), Zenyu Shiokawa (1992451), Ryokichi Koyama (4170256), Nobuyuki Negoro (2089417), Takashi Imada (2093686), Chien-Hung Chen (367115), Tomoya Yukawa (2357164), Tetsuji Kawamoto (2433148), BiChing Sang (6294458), Junya Shirai (4962877), Ayumu Sato (2565280), Tsuneo Oda (4962886), Yoshihiro Banno (2231680), Terufumi Takagi (1920943), Isaac Hoffman (6294455), Ryosuke Katsuyama (6294461), Satoshi Yamamoto (316085), Mitsunori Kono (1786432), Naohiro Taya (1992463)   +22 more
core   +1 more source

CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17 cells

JCI Insight, 2021
Invariant NKT (iNKT) cells are potent immunomodulatory cells that acquire effector function during their development in the thymus. IL-17–producing iNKT cells are commonly referred to as NKT17 cells, and they are unique among iNKT cells to express the ...
Shunqun Luo, Juntae Kwon, Assiatu Crossman, Pyong Woo Park, Jung-Hyun Park   +4 more
doaj   +1 more source

TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge

Mucosal Immunology, 2022
Eosinophils are best known for their effector functions in settings of parasitic infection or allergen challenge, but have also increasingly been implicated in immune regulation at mucosal sites.
Angela Fallegger, Martina Priola, Mariela Artola-Borán, N. Núñez, Sebastian Wild, Alessandra Gurtner, B. Becher, S. Yousefi, H. Simon, I. Arnold, A. Müller   +10 more
semanticscholar   +1 more source

RORγt expression in lung eosinophils assessed using RORγt-mCherry reporter mice.

, 2021
(A) Flow cytometry (allergy model). Allergic aspergillosis was induced in wild-type and RORγt-mCherry reporter mice as in Fig 1A. Eosinophils from lung cells were analyzed for expression of the mCherry signal.
Bhawna Yadav (172612), Maria Pokrovskii (11362107), Jun R. Huh (2004790), Stuart M. Levitz (10326566), Chrono K. Lee (11362104), Charles A. Specht (10326563), Dan R. Littman (82)   +6 more
core   +1 more source

Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt

Nature Immunology
The gut experiences daily fluctuations in microbes and nutrients aligned with circadian rhythms that regulate nutrient absorption and immune function. Group 3 innate lymphoid cells (ILC3s) support gut homeostasis through interleukin-22 (IL-22) but can ...
Bishan Bhattarai, A. U. Antonova, J. Fachi, Leone S. Hopkins, Matthew V. D. McCullen, Ankita Saini, Sarah de Oliveira, Wandy L. Beatty, E. Musiek, V. Kuchroo, Mitchell A. Lazar, E. Oltz, Marco Colonna   +12 more
semanticscholar   +1 more source