Results 71 to 80 of about 22,496 (211)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation. [PDF]

PLoS ONE, 2015
CD4+ T-helper cells that produce interleukin-17 (Th17 cells) are characterized as pathological T-helper cells in autoimmune diseases. Differentiation of human and mouse Th17 cells requires a key transcription regulator, retinoic acid receptor-related ...
Qingfeng Ding, Mei Zhao, Bolan Yu, Chuan Bai, Zhaofeng Huang   +4 more
doaj   +1 more source

Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases.

Pharmacological Research
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and persistent inflammation.
M. Biagioli, C. Di Giorgio, E. Morretta, Rachele Bellini, Carmen Massa, G. Urbani, M. Bordoni, S. Marchianò, Ginevra Lachi, V. Sepe, M. C. Monti, E. Distrutti, A. Zampella, S. Fiorucci   +13 more
semanticscholar   +1 more source

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

Nature Communications, 2021
Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole ...
B. Jensen, J. Holm, I. Larsen, Nicole von Burg, S. Derer, S. B. Sonne, Simone I. Pærregaard, Mads T. F. Damgaard, Stine A. Indrelid, Aymeric Rivollier, Anne-Laure Agrinier, Karolina Sulek, Y. J. Arnoldussen, E. Fjære, A. Marette, I. Angell, K. Rudi, J. T. Treebak, L. Madsen, C. P. Åkesson, W. Agace, C. Sina, C. Kleiveland, K. Kristiansen, T. Lea   +24 more
semanticscholar   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Synthetic RORγt Agonists Enhance Protective Immunity

, 2016
The T cell specific RORγ isoform RORγt has been shown to be the key lineage-defining transcription factor to initiate the differentiation program of TH17 and TC17 cells, cells that have demonstrated antitumor efficacy.
Patrick R. Griffin (554018), Ruben D. Garcia-Ordonez (1429621), Scott J. Novick (1429612), Dana S. Kuruvilla (1429615), Mi Ra Chang (1429624), Venkatasubramanian Dharmarajan (1429609), Theodore M. Kamenecka (131143), Christelle Doebelin (1429618)   +7 more
core   +1 more source

Structural change of retinoic-acid receptor-related orphan receptor induced by binding of inverse-agonist: Molecular dynamics and ab initio molecular orbital simulations

Computational and Structural Biotechnology Journal, 2020
To elucidate structural changes in the retinoic acid receptor-related orphan receptor gamma (RORγt) induced by the binding of an agonist or an inverse agonist, we conducted molecular dynamics (MD) simulations in explicit water.
Shusuke Suzuki, Toshiya Nakamura, Ryosuke Saito, Yuta Terauchi, Kentaro Kawai, Midori Takimoto-Kamimura, Noriyuki Kurita   +6 more
doaj   +1 more source

A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells

Frontiers in Immunology, 2023
BackgroundAs an important early source of IL-17A and IL-22 in immune responses, type 3 innate lymphoid cells (ILC3s) are critically regulated by the transcription factor retinoic-acid-receptor-related orphan receptor gamma t (RORγt).
Dehui Chang, Hao Zhang, Jing Ge, Qi Xing, Xinyi Guo, Xiaohu Wang, Chen Dong, Chen Dong, Chen Dong, Chen Dong   +9 more
doaj   +1 more source

Decoupling the role of RORγt in the differentiation and effector function of TH17 cells

Science Advances, 2022
RORγt is known to instruct the differentiation of T helper 17 (TH17) cells that mediate the pathogenesis of autoimmune diseases. However, it remains unknown whether RORγt plays a distinct role in the differentiation and effector function of TH17 cells ...
Xiancai Zhong, Hong-Min Wu, Wen-Can Zhang, Y. Gwack, W. Shang, Kyle O. Lee, N. Isakov, Zhi-Heng He, Zuo-Ming Sun   +8 more
semanticscholar   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source