Results 91 to 100 of about 22,496 (211)

Id1 induces apoptosis through inhibition of RORgammat expression

BMC Immunology, 2008
Background Basic helix-loop-helix E proteins are transcription factors that play crucial roles in T cell development by controlling thymocyte proliferation, differentiation and survival.
Sun Xiao-Hong, Wang Hong-Cheng, Yang Yuanzheng   +2 more
doaj   +1 more source

Age‐Associated B Cells Contribute to Inflammation Via Antibody‐Independent Mechanisms in Takayasu Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang, Xiaoxi Yang, Xiaochuan Sun, Shangyi Jin, Lihong Du, Jinwei Gao, Jing Li, Zhen Chen, Yuexin Chen, Mengtao Li, Xinping Tian   +10 more
wiley   +1 more source

Th17 cells and their cytokines serve as potential therapeutic target in experimental autoimmune neuritis

Brain and Behavior, 2019
Background Accumulating evidence has pointed that T helper 17 cells and their cytokines are pathogenic in Guillain–Barré syndrome (GBS). However, little is known concerning the IL‐17 expression change trend during the whole course of disease, and whether
Shuping Liu, Yin Liu, Zheman Xiao, Sijia Pan, Qiaoyu Gong, Zuneng Lu   +5 more
doaj   +1 more source

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon

Frontiers in Immunology, 2019
The active form of vitamin D (1,25(OH)2D) suppresses experimental models of inflammatory bowel disease in part by regulating the microbiota. In this study, the role of vitamin D in the regulation of microbe induced RORγt/FoxP3+ T regulatory (reg) cells ...
Margherita T. Cantorna, Margherita T. Cantorna, Yang-Ding Lin, Yang-Ding Lin, Juhi Arora, Juhi Arora, Stephanie Bora, Stephanie Bora, Yuan Tian, Yuan Tian, Yuan Tian, Robert G. Nichols, Andrew D. Patterson   +12 more
doaj   +1 more source

lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORγt Protein

Journal of Immunology Research, 2022
Objective. From our previous study, we obtained long noncoding RNA (lncRNA) STAT4-AS1, which is related to asthma through high-throughput screening. However, we could not determine the specific mechanism involved and in response to this.
Hanlin He, Xiangjie Qiu, Mingming Qi, Ousman Bajinka, Ling Qin, Yurong Tan   +5 more
doaj   +1 more source

Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage

American Journal of Nephrology, 2022
Introduction: Chronic activation of the mineralocorticoid receptor (MR) leads to pathological processes like inflammation and fibrosis during cardiorenal disease. Modulation of immunological processes in the heart or kidney may serve as a mechanistic and
Katja Luettges, M. Bode, J. Diemer, J. Schwanbeck, E. Wirth, R. Klopfleisch, K. Kappert, Arne Thiele, D. Ritter, A. Foryst-Ludwig, P. Kolkhof, U. Wenzel, U. Kintscher   +12 more
semanticscholar   +1 more source

RORγt-expressing T cells in the lungs of WT and RORγt-tg mice after MAC infection.

, 2016
(A) The proportion of CD4-positive T cells expressing RORγt and/or T-bet in the lungs of WT and RORγt-tg mice 2 months after an intratracheal inoculation of 1 x 107 CFU of MAC or saline (Cont).
Satoru Takahashi (32871), Keigyou Yoh (846504), Hirofumi Sakurai (846502), Nobuyuki Hizawa (212942), Yukio Ishii (846501), Masashi Matsuyama (846500), Satoshi Ano (846503), Yuko Morishima (467418), Kenji Ogawa (448553)   +8 more
core   +1 more source

A Central Role for Atg5 in Microbiota-Dependent Foxp3+ RORγt+ Treg Cell Preservation to Maintain Intestinal Immune Homeostasis

Frontiers in Immunology, 2021
Autophagy is an evolutionary conserved catabolic pathway that ensures the degradation of intracellular components. The autophagic pathway is regulated by autophagy-related (Atg) proteins that govern formation of double-membraned vesicles called ...
Carlos Plaza-Sirvent, Carlos Plaza-Sirvent, Carlos Plaza-Sirvent, Bei Zhao, Alisha W. Bronietzki, Alisha W. Bronietzki, Marina C. Pils, Neda Tafrishi, Marc Schuster, Marc Schuster, Till Strowig, Till Strowig, Ingo Schmitz, Ingo Schmitz, Ingo Schmitz   +14 more
doaj   +1 more source

Gut Microbiota Promotes Immune Tolerance by Regulating RORγt+ Treg Cells in Food Allergy

Advanced Gut & Microbiome Research, 2022
Food allergy is a significant public health problem troubling people, and the incidence has been on the rise in the past decade. Emerging evidence suggests an influence of the gut microbiota in susceptibility to food allergies.
Xixi Ning, Zengjie Lei, Binqi Rui, Yuyuan Li, Ming Li   +4 more
semanticscholar   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source