Results 101 to 110 of about 22,496 (211)

Triggering Receptor Expressed on Myeloid Cells‐2 Regulates Innate Lymphoid Cell Levels in Bleomycin‐Induced Pulmonary Fibrosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Idiopathic pulmonary fibrosis, a pathological change causing poor outcomes, is not reversible despite current antifibrotic therapy. Emerging evidence suggests that innate lymphoid cells (ILCs) mediate lung inflammation and fibrosis after stimulation by endogenous factors.
Hsiao‐Chin Shen, Nien‐Jung Chen, Chuan‐Yen Sun, Wen‐Kuang Yu, Vincent Yi‐Fong Su, Wan‐Ling Yang, Wei‐Chih Chen, Kuang‐Yao Yang   +7 more
wiley   +1 more source

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Immunity, 2019
Summary Microbiota are thought to influence the development and progression of inflammatory bowel disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires larger‐scale functional analyses.
G. Britton, Eduardo J. Contijoch, I. Mogno, Olivia H. Vennaro, Sean R. Llewellyn, Ruby Ng, Zhi-Hua Li, A. Mortha, M. Merad, Anuk M. Das, D. Gevers, D. McGovern, Namita Singh, J. Braun, J. Jacobs, J. Clemente, A. Grinspan, B. Sands, J. Colombel, M. Dubinsky, J. Faith   +20 more
semanticscholar   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Characterization of the developmental landscape of murine RORγt+ iNKT cells

, 2019
International audienceInvariant natural killer T (iNKT) cells expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice.
Toubert, Antoine, Brunet, Stéphane, Amable, Ludivine, Lucas, Bruno, Delord, Marc, Marie, Julien,, Eberl, Gérard, Parietti, Véronique, Li, Shamin, Klibi, Jihène, Benlagha, Kamel, Joseph, Claudine, Jaubert, Jean, Marie, Julien, C., Karray, Saoussen   +14 more
core   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Data_Sheet_3_Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells.PDF

, 2020
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota.
Hind Hussein (8267022), Frédéric Van Gool (198333), Yousra Ajouaou (8267028), Oberdan Leo (33376), Abdulkader Azouz (8267025), Hana El-Khatib (8267031), Fabienne Andris (256321), Sébastien Denanglaire (502353), Guillaume Oldenhove (8267034)   +8 more
core   +1 more source

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy, Lei Cheng, De‐Yun Wang   +2 more
wiley   +1 more source

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

Allergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia A. Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Jens Geginat   +18 more
wiley   +1 more source

Inhibition of RORγt activity in 293T cells.

, 2015
RORγt+-293T stable cells were culture in the presence of hit compounds (5 μM) and DMSO (vehicle control) for 6 h. Then the luciferase activity in RORγt+-293T cells were recorded.
Qingfeng Ding (795498), Bolan Yu (514237), Zhaofeng Huang (124948), Mei Zhao (177004), Chuan Bai (548830)   +4 more
core   +1 more source

Mapping of RORγt+ dendritic cells in human tissues establishes their preferential niche in adult lymph nodes

Frontiers in Immunology
BackgroundThe retinoic-acid-receptor-related orphan receptor gamma t (RORγt) isoform is required for the development of lymphoid organs, T-helper 17 cells (Th17), and innate lymphoid cells (ILC3s).
Silvia Lonardi, Francisco MA Bianchetto-Aguilera, Matilde Monti, Anna Di Matteo, Francesco Missale, Francesco Missale, Sara Picinoli, Mattia Bugatti, Martina Benedetti, Giorgia Ferrari, Marco A. Cassatella, Daniele Moratto, Stefania Zini, Valentina Agostini, Viola Savoldi, Luisa Lorenzi, Marco Chiarini, Fabio Facchetti, Shitong Wu, Alina Ulezko Antonova, Yizhou A. Liu, Marina Cella, Claudia Ghigna, Marco Colonna, William Vermi, William Vermi   +25 more
doaj   +1 more source