Results 111 to 120 of about 22,496 (211)

Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

Nature Communications, 2018
The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the ...
Zhiheng He, Jing Zhang, Zhaofeng Huang, Qian Du, Ning Li, Qiang Zhang, Yuan Chen, Zuoming Sun   +7 more
doaj   +1 more source

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Nature Communications, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
K. Venken, Peggy Jacques, C. Mortier, M. Labadia, T. Decruy, J. Coudenys, K. Hoyt, A. Wayne, Robert Hughes, Michael Turner, S. van Gassen, L. Martens, Dustin Smith, C. Harcken, J. Wahle, Chao-Ting Wang, Eveline Verheugen, N. Schryvers, G. Varkas, H. Cypers, R. Wittoek, Y. Piette, L. Gyselbrecht, S. van Calenbergh, F. E. Van den Bosch, Y. Saeys, G. Nabozny, D. Elewaut   +27 more
semanticscholar   +1 more source

Development and evolution of RORγt+ cells in a microbe’s world

, 2011
International audienceThe nuclear hormone receptor retinoid-related orphan receptor γt (RORγt) induces a pro-inflammatory program in lymphoid cells, culminating in the expression of interleukin-6 (IL-6), IL-17, IL-22, granulocyte-macrophage colony ...
Eberl, Gérard, Gérard Eberl
core   +1 more source

Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells

Cell Reports, 2018
Summary: Foxp3+ regulatory T cells (Treg) are essential modulators of immune responses, but the molecular mechanisms underlying their function are not fully understood.
Chihiro Ogawa, Rashmi Bankoti, Truc Nguyen, Nargess Hassanzadeh-Kiabi, Samantha Nadeau, Rebecca A. Porritt, Michael Couse, Xuemo Fan, Deepti Dhall, Gerald Eberl, Caspar Ohnmacht, Gislâine A. Martins   +11 more
doaj   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists

, 2016
A novel series of tertiary amines as retinoid-related orphan receptor gamma-t (RORγt) inverse agonists was discovered through agonist/inverse agonist conversion. The level of RORγt inhibition can be enhanced by modulating the conformational disruption of
Zhijun Xiang (1668100), Stewart Leung (131239), Liuqing Yang (128705), Qianqian Wu (818952), Yonghui Wang (287491), Qian Liu (135614), Wei Zhang (405), Ting Yang (189879), Yingli Ma (1860352), Zhong Zhong (131243), Ling Zhou (51948), John D. Elliott (1860346), Jia-Ning Xiang (1422334), Yaobang Cheng (1668106), Jing Zhang (23775), Xichen Lin (1422340), Yang Qiu (368797), Lisa A. Orband-Miller (1276785), Wei Cai (121428), Melanie Huxdorf (1860349)   +19 more
core   +1 more source

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

Frontiers in Immunology, 2019
The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (RORγt) is the key transcription factor required for Th17 cell differentiation and for production of IL-17 family cytokines by innate and adaptive immune cells ...
Florence Ecoeur, Jessica Weiss, Klemens Kaupmann, Samuel Hintermann, David Orain, Christine Guntermann   +5 more
doaj   +1 more source

The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk

Allergy, EarlyView.
ABSTRACT IgE‐mediated food allergy is a global health issue with rising prevalence that cannot be explained by genetic change alone, strongly suggesting that environmental exposures are a key driver. The external exposome encompasses several exposures that influence the developing immune system and modify food allergy risk.
Johanna M. Smeekens, Helen A. Brough, Kirsi M. Järvinen, Sophie Troyer, Michael D. Kulis, Timothy P. Moran   +5 more
wiley   +1 more source

Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt + T cells

Life Science Alliance, 2020
Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103 + CD11b + cDC2s, which was accompanied with impaired differentiation of both Rorγt + Th17 cells and type 3 Rorγt + Treg cells.
Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Ohno-Oishi, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi   +12 more
doaj   +1 more source

Failed Mucosal Allostasis Distinguishes Murine IgG‐ From IgE‐Mediated Recurrent Severe Anaphylaxis

Allergy, EarlyView.
This study investigates IgE‐ and IgG‐mediated pathways in acute and recurrent anaphylaxis using a murine ASA‐PSA model, assessing barrier integrity, immune activation and tissue remodelling across pulmonary and intestinal compartments. Recurrent IgE‐ and IgG‐mediated anaphylaxis produces divergent mucosal outcomes despite comparable systemic severity ...
Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Sude Toprakkaz, Mehmet Emre Topcu, Musa Ozgur Ozyigit, Ahmet Akkoc, Dane Ediger, Ferah Budak Sener   +8 more
wiley   +1 more source