Results 131 to 140 of about 22,496 (211)

Data_Sheet_6_Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells.PDF

, 2020
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota.
Hind Hussein (8267022), Frédéric Van Gool (198333), Yousra Ajouaou (8267028), Oberdan Leo (33376), Abdulkader Azouz (8267025), Hana El-Khatib (8267031), Fabienne Andris (256321), Sébastien Denanglaire (502353), Guillaume Oldenhove (8267034)   +8 more
core   +1 more source

Dysregulation of Wnt/β-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells

Nature Communications
RORγt+ group 3 innate lymphoid cells (ILC3s) are essential for intestinal homeostasis. Dysregulation of ILC3s has been found in the gut of patients with inflammatory bowel disease and colorectal cancer, yet the specific mechanisms still require more ...
Jiacheng Hao, Chang Liu, Zhijie Gu, Xuanming Yang, Xun Lan, Xiaohuan Guo   +5 more
doaj   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Establishment of the 293T-RORγt and Jurkat-RORγt reporter cell lines.

, 2015
The pGL4.31 reporter plasmids were transfected into 293T cells. The transfected cells were then selected in medium containing hygromycin B to obtain a stable clone which express pGL4.31 reporter gene.
Qingfeng Ding (795498), Bolan Yu (514237), Zhaofeng Huang (124948), Mei Zhao (177004), Chuan Bai (548830)   +4 more
core   +1 more source

Data_Sheet_1_Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells.PDF

, 2020
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota.
Hind Hussein (8267022), Frédéric Van Gool (198333), Yousra Ajouaou (8267028), Oberdan Leo (33376), Abdulkader Azouz (8267025), Hana El-Khatib (8267031), Fabienne Andris (256321), Sébastien Denanglaire (502353), Guillaume Oldenhove (8267034)   +8 more
core   +1 more source

Table_1_Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro.docx

, 2021
IntroductionCD4+ T cells with regulatory function co-expressing Foxp3 and RORγt are linked to the development of oral tolerance towards innocuous food antigens in mice.
Daniel Lozano-Ojalvo (2577973), Sara Benedé (485367), Rosina López-Fandiño (485368), Mónica Martínez-Blanco (11253063), Leticia Pérez-Rodríguez (11253066), Elena Molina (485370)   +5 more
core   +1 more source

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

, 2019
Retinoic acid receptor-related orphan receptor γt (RORγt) is a nuclear receptor associated with the pathogenesis of autoimmune diseases. Allosteric inhibition of RORγt is conceptually new, unique for this specific nuclear receptor, and offers advantages ...
L Brunsveld (8406369), RG Doveston (7714598), AAA Vos (8406354), GM Vos (8406351), S Leysen (8406357), FA Meijer (8406345), C Ottmann (8406363), M Scheepstra (8406360), LG Milroy (8406366), RMJM De Vries (8406348)   +9 more
core   +3 more sources

Intestinal STING‐(Over)activation—A Contributing Factor to Food Allergies?

Allergy, EarlyView.
Sophie Goebel, Hannah Ruth Schiller
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach, Ausra Ramanauskaite, Sašo Ivanovski, Pingping Han, Frank Schwarz, Emilio A. Cafferata   +5 more
wiley   +1 more source