Results 151 to 160 of about 22,496 (211)

RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis.

PLoS ONE
Multiple genetic associations suggest a causative relationship between Th17-related genes coding for proteins, such as IL-17A, IL-23 and STAT3, and psoriasis.
Mia Collins, Rikard Pehrson, Hanna Grindebacke, Agnes Leffler, Marie Ramnegård, Helena Rannikmäe, Nina Krutrök, Linda Yrlid, Charlotte Pollard, Ian Dainty, Frank Narjes, Stefan von Berg, Antonio Llinas, Anna Malmberg, Jane McPheat, Eva Hansson, Elisabeth Bäck, Jenny Bernström, Thomas G Hansson, David Keeling, Johan Jirholt   +20 more
doaj   +1 more source

Critical Evaluation of the Role of Transcription Factor RAR-Orphan Receptor-γt in the Development of Chronic Inflammatory Dermatological Diseases: A Promising Therapeutic Target

Biomolecules
Nuclear receptors (NRs) are transcription factors regulated by ligands that direct metabolism, development, and immunity. The NR superfamily constitutes a principal category of pharmacological targets for human ailments.
Anik Pramanik, Pallabi Mondal, Sankar Bhattacharyya   +2 more
doaj   +1 more source

Protective role of RORγt-dependent hepatic ILCs in acute hepatitis.

, 2013
RORγt-dependent hepatic ILCs attenuate acute liver injury through the production of IL-22.
Atsuhiro Matsumoto (405471), Nobuhiro Nakamoto (267143), Toshifumi Hibi (105885), Takanori Kanai (185812), Hideo Yagita (109170), Hidetsugu Saito (193796), Hirotoshi Ebinuma (193765), Po–Sung Chu (405473), Yohei Mikami (405472), Toshiro Sato (405474)   +9 more
core   +1 more source

B7 co-stimulation antagonizes RORγt+ regulatory T cells and tolerance to gut microbiota 2254003

Introduction Regulatory T (Treg) cells recognizing dietary or microbiota-derived antigens express RORγt and are essential for intestinal immune tolerance.
Gregory Sonnenberg, Mengze Lyu
core   +1 more source

Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt

, 2017
Transcription factor retinoid acid–related orphan receptor (ROR)γt transcriptionally regulates the genes required for differentiation of Th17 cells that mediate both protective and pathogenic immunity.
Zhiheng He, Zuoming Sun, Fei Wang, Shengwei Luo, Jing Zhang, Yousang Gwack, Qihua Pang, Subha Sen   +7 more
core   +1 more source

RORγt is crucial for gut homeostasis by regulating the expression of HB-EGF rather than IL-22 in activated ILC3s

Cell Reports
Summary: RORγt inhibition shows potential for treating T helper 17 (Th17) cell-related inflammatory disorders. However, there is a lack of a comprehensive understanding of its influence on the immune system.
Peng Li, Yime Zhang, Yang Shen, Xingyu Zhao, Rong Mu, Chao Zhong   +5 more
doaj   +1 more source

RORγt eTACs mediate oral tolerance and Treg induction.

Journal of Experimental Medicine
Im-Hong Sun, A. E. Qualls, Han S Yin, Jia-Xi Wang, Matthew P. Arvedson, Joe Germino, Nolan K Horner, Sheng Zhong, Juan Du, M. Valdearcos, V. Ntranos, R. Locksley, R. Ricardo-Gonzalez, James M. Gardner   +13 more
semanticscholar   +1 more source

ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review). [PDF]

Int J Mol Med
Zhang J, Bao L, Li J, Li X, Qiao L, Cui J, He X, Zhang M, Lu J, Zhang X, Dong J, Tao G, Feng Y, Tian YP, Zhao P, Tuo Y.   +15 more
europepmc   +1 more source

ILC plasticity in intestinal immune barrier remodeling: current evidence and therapeutic implications for inflammatory bowel disease. [PDF]

Front Immunol
Zhou Z, Ling P, Wang J, Zhang X, Shen Y.
europepmc   +1 more source

A temporal differentiation program after birth delineates γδ T cell immunity. [PDF]

Sci Adv
Baglioni MV, Fares da Silva MGF, Sonnenholzner A, Rizk J, Copland A, Catafal-Tardos E, Secci D, Peñalver-Sebastián P, Laursen MF, Kappel SS, Oehlenschlæger J, Ellebæk MB, Zachariassen G, Aunsholt L, Bending D, Olsen LR, Bekiaris V.   +16 more
europepmc   +1 more source