Results 81 to 90 of about 22,496 (211)

Validation of the Jurkat-RORγt-LBD stable cell lines.

, 2015
RORγt+-Jurkat (RORγt-LBD positive Jurkat cells) and RORγt--Jurkat (RORγt-LBD negative Jurkat cells) stable cells (1x105) were seeded onto 12-well plates and incubated in 1 mL RPMI 1640 complete medium overnight.
Qingfeng Ding (795498), Bolan Yu (514237), Zhaofeng Huang (124948), Mei Zhao (177004), Chuan Bai (548830)   +4 more
core   +1 more source

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Cell Reports, 2016
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP ...
Yanxia Guo, Kenzie D. MacIsaac, Yi Chen, Richard J. Miller, Renu Jain, Barbara Joyce-Shaikh, Heidi Ferguson, I-Ming Wang, Razvan Cristescu, John Mudgett, Laura Engstrom, Kyle J. Piers, Gretchen A. Baltus, Kenneth Barr, Hongjun Zhang, Huseyin Mehmet, Laxminarayan G. Hegde, Xiao Hu, Laura L. Carter, Thomas D. Aicher, Gary Glick, Dennis Zaller, Abbas Hawwari, Craig C. Correll, Dallas C. Jones, Daniel J. Cua   +25 more
doaj   +1 more source

Altered Expression of STAT3, RORγt, and IL-17A Proteins and Th17 Cell in Intrahepatic Cholestasis of Pregnancy

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Intrahepatic cholestasis of pregnancy (ICP) is a disorder specifically associated with pregnancy. Recent evidence suggests that the T helper 17 (Th17) cell population is related to a maternal and foetal immune imbalance associated with ICP ...
Yu-Xia Wu, Qian Chen, Qiu-He Chen, Dan Shan, Ya-Yi Hu   +4 more
doaj   +1 more source

Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt

Science Advances, 2021
Dysbiosis of gut microbiota might promote the pathophysiological process of aCSVD. The intestinal microbiota shape the host immune system and influence the outcomes of various neurological disorders. Arteriosclerotic cerebral small vessel disease (aCSVD)
Wei Cai, Xiao-Dong Chen, Xue-Jiao Men, Heng-Fang Ruan, Meng-Yan Hu, Sanxin Liu, T. Lu, J. Liao, Bing-Jun Zhang, Danli Lu, Yinong Huang, P. Fan, Jun-Ping Rao, C. Lei, Ji-Hui Wang, Xiao-Meng Ma, Qiang Zhu, Lili Li, Xiu-Yun Zhu, Yujiao Hou, Shu Li, Qing Dong, Qing Tian, Lulu Ai, Wenjing Luo, Meng Zuo, Li-Ping Shen, Congyan Xie, Hongzhong Song, Ganlin Xu, Kang-Di Zheng, Zhao Zhang, Yong-Jun Lu, W. Qiu, Tao Chen, A. Xiang, Zheng-Qi Lu   +36 more
semanticscholar   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors [PDF]

, 2017
The nuclear receptor retinoid acid receptor-related orphan receptor γt (RORγt) is a master regulator of the Th17/IL-17 pathway that plays crucial roles in the pathogenesis of autoimmunity.
Mark E. Labadia, Siqi Lin, Brennan, D, Kennedy, C, Debra Brennan, Collin, D, John Wan, Cook, B, Stanley Kugler, Kugler, S, Lin, S, Hughes, R, Ingo Muegge, Charles Kennedy, Xiang Li, Delphine Collin, Wan, J, Anderson, M, Labadia, ME, Farrow, NA, Terenzio, D, Robert Hughes, Donna Terenzio, Neil A. Farrow, Li, X, Marie Anderson, Brian Cook, Muegge, I   +27 more
core   +1 more source

Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Scientific Reports, 2021
The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune cells. The IL-23/IL-17 axis is implicated in several
Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, Michael Albers, Freddy Schoetens, S. Deprimo, D. Devineni, Thomas Wilde, S. Goldberg, O. Kinzel, Thomas Hoffmann, A. Fourie, R. Thurmond   +13 more
semanticscholar   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Validation of the 293T-RORγt-LBD stable cell lines.

, 2015
RORγt+-293T (RORγt-LBD positive 293T cells) and RORγt--293T (RORγt-LBD negative 293T cells) stable cells (1x105) were seeded onto 12-well plates and incubated in 1 mL DMEM complete medium overnight.
Qingfeng Ding (795498), Bolan Yu (514237), Zhaofeng Huang (124948), Mei Zhao (177004), Chuan Bai (548830)   +4 more
core   +1 more source

Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation

Journal of Advanced Research
Introduction: Retinoic acid receptor-related orphan receptor gamma t (RORγt) is a crucial transcription factor regulating Th17 cells, which secrete the cytokine IL-17.
Hojin Yoo, Sang-Jun Han, Jeong-Eun Lee, Chaeyeon Cho, Donggyun Hong, Birang Jeong, Sijin Kim, Go-Yeon Jung, Minjeong Ma, Soeun Jung, Beomjun Park, Namgil Lee, Hee-Seop Yoo, Kwang-Jin Cho, Min-Duk Seo, Yeonseok Chung, Byung-Seok Kim, Heejung Yang   +17 more
doaj   +1 more source