Results 61 to 70 of about 22,496 (211)

Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity

Cell Reports, 2017
Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt+ Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study,
Byung-Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi-Bing Zhang, Nipun A. Mistry, Kentaro Tanaka, Young-hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, Chen Dong   +14 more
doaj   +1 more source

RORγt Mediates Angiotensin II‐Induced Pressor Responses, Microglia Activation, and Neuroinflammation by Disrupting the Blood–Brain Barrier in Rats

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease
Background The RORγt (nuclear receptor retinoid‐related orphan receptor γt) has been identified as a master transcription factor critical for the differentiation of T helper 17 cells, the primary source of IL‐17A (interleukin‐17A).
Yang Yu, Baojian Xue, Lei Tong, Alexander G Bassuk, Alan K. Johnson, Shun-Guang Wei   +5 more
semanticscholar   +1 more source

Hepatic ILCs express RORγt and are decreased in RAG-2^−/− × RORγt^−/− mice.

, 2013
(A) RORγt expression in hepatic MNCs. RORγt mRNA expression in the indicated hepatic MNCs subsets was measured by RT-qPCR and normalized relative to β-actin expression. Error bars represent SEM of triplicate samples.
Atsuhiro Matsumoto (405471), Nobuhiro Nakamoto (267143), Toshifumi Hibi (105885), Takanori Kanai (185812), Hideo Yagita (109170), Hidetsugu Saito (193796), Hirotoshi Ebinuma (193765), Po–Sung Chu (405473), Yohei Mikami (405472), Toshiro Sato (405474)   +9 more
core   +1 more source

Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The interplay between the dysbiotic microbiota and bile acids is a critical determinant for development of a dysregulated immune system in inflammatory bowel disease (IBD).
M. Biagioli, C. Di Giorgio, Carmen Massa, S. Marchianò, Rachele Bellini, M. Bordoni, G. Urbani, Rosalinda Roselli, Ginevra Lachi, E. Morretta, F. Dal Piaz, B. Charlier, Bianca Fiorillo, B. Catalanotti, L. Cari, G. Nocentini, Patrizia Ricci, E. Distrutti, C. Festa, V. Sepe, A. Zampella, M. C. Monti, S. Fiorucci   +22 more
semanticscholar   +1 more source

RORγt Promotes Foxp3 Expression by Antagonizing the Effector Program in Colonic Regulatory T Cells

Journal of Immunology, 2021
RORγt is the master transcription factor for the Th17 cells. Paradoxically, in the intestine, RORγt is coexpressed in peripherally induced regulatory T cells (pTregs) together with Foxp3, the master transcription factor for Tregs.
Suniti Bhaumik, Michel-Edwar Mickael, Monica Moran, M. Spell, R. Basu   +4 more
semanticscholar   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

Journal of Biomedical Sciences
The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown.
Qiu-Ming Zeng, Hui Guo, Na Tang, Pranav S. Renavikar, Nitin J Karandikar, A. Lovett-Racke, M. Racke, Chengkai Yan, Rong Tang, Sushmita Sinha, Krishnendu Ghosh, Jeremy P. Ryal, S. Ouyang, Min Chen, F. Amari, Coppola Vincenzo, R. M. Pope, Yalan Li, Huan Yang, Wallace Y. Langdon, Jian Zhang   +20 more
semanticscholar   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand

, 2021
The RORγt nuclear receptor (NR) is of critical importance for the differentiation and proliferation of T helper 17 (Th17) cells and their production of the pro-inflammatory cytokine IL-17a.
Oerlemans, Guido J.M., Meijer, Femke A., Brunsveld, Luc, Brunsveld, Luc; id_orcid   +3 more
core   +1 more source

Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis.

Journal of Medicinal Chemistry
The retinoic acid receptor-related orphan receptor gamma t (RORγt) is a nuclear transcription factor expressed in both innate and adaptive immune cells, driving Th17 cell differentiation and IL-17 production.
O. Kinzel, Steven D Goldberg, Maxwell D. Cummings, Christian Gege, Christoph Steeneck, Xiaohua Xue, Michael Albers, Thomas Schlüter, G. Kleymann, Brian Scott, Kia Sepassi, Freddy Schoetens, H. Venkatesan, Virginia M. Tanis, Kevin Coe, Zachary S. Sales, J. Spurlino, Cynthia M. Milligan, A. Fourie, James P. Edwards, T. Hoffmann   +20 more
semanticscholar   +1 more source